CAS: 120067-83-6; Fipronil-Sulfide

该化合物是合成氟化物的关键中间体,一种广泛频谱的苯丙烯杀虫剂,化学上称为5-氨-1-[2,6-二氯-4-(三氟甲基)苯基]-4-(三氟甲基)硫基-硫化物-1H-苯甲醇-3-碳三联苯,硫化物是氧化过程的一种前体,可生产氟化物,对蚂蚁,蟑螂和白蚁等害虫具有很高的功效,其稳定性和再活性使其成为农业化学配方中的一种有价值的化合物.氟化物的特点是对昆虫有选择性毒性,哺乳动物毒性低,而且具有持久性,由于其可靠性能和与综合虫害管理系统的兼容性,该化合物广泛用于作物保护和兽医产品.

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物理性质

MSDS等安全信息

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上下游产品

CAS号421-17-0 三氟甲基硫氯 | CAS号120068-79-3 5-氨基-3-氰基-1-(2,... | CAS号120069-10-5 5-amino-1-(2,6-... | CAS号75-63-8 三氟溴甲烷 | CAS号2926-29-6 三氟代甲烷亚磺酸钠 | CAS号130755-46-3 5-amino-4-[[5-a... | CAS号5329-14-6 氨基磺酸 | CAS号120068-37-3 氟虫腈 | CAS号7446-09-5 二氧化硫 | CAS号120068-37-3 氟虫腈 | CAS号120068-36-2 氟虫腈砜

合成工艺路线路线简述

    📜氟虫腈置于三氟乙酸酐,Sodium Iodide体系中,用 丙酮 用作溶剂,化学反应 10.0H,以60%的收率获得5-氨基-1-(2,6-二氯-对三氟甲基苯胺基)-3-腈-4-三氟甲基硫基吡唑
    参考文献:Synthesis Of Fipronil Sulfide,An Active Metabolite,From The Parent Insecticide Fipronil
    标题:Synthesis Of Fipronil Sulfide,An Active Metabolite,From The Parent Insecticide Fipronil
    摘要:A Convenient Procedure For The Synthesis Of Fipronil Sulfide,One Of Several Active Metabolites Identified From The Insecticide Fipronil,Has Been Developed. Reduction Of Fipronil With Trifluoroacetic Anhydride-Sodium Iodide In Acetone,Followed By Rash Chromatography Afforded Fipronil Sulfide In 60% Yield And > 99.9 Percent Purity. This Represents The First Direct Synthesis Of This Key Metabolite From Fipronil. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
    Doi:10.1016/s0040-4039(01)01043-7

    海关参考信息

    专利信息


    专利号:WO-2010049789-A1
    优先权日:2008-10-27
    标 题 :Process for the synthesis of fipronil
    发明人：JUELICH ALEXANDER; TILLICH JOACHIM
    权利人:DYNAMIT NOBEL AG; JUELICH ALEXANDER; TILLICH JOACHIM
    摘要:This invention relates to a process for the continuous synthesis of 5-amino-1-[2,6- dichloro-4-(rifluoromethyl)phenyl]-4-(rifluoromethylsulfinyl)-1H-pyrazole-3-carbonitrile comprising the step of reacting in a solvent 5-amino-1-[2,6-dichloro-4- (trifluoromethyl)phenyl]-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile with an oxidizing agent. The process provides a more efficient and more robust process than the existing processes.

    专利号:US-8507693-B2
    优先权日:2010-03-03
    标 题:Process for synthesis of fipronil
    发明人：GHARDA KEKI HORMUSJI
    权利人:GHARDA KEKI HORMUSJI
    摘要:The present disclosure relates to a process for trifluoromethylsulfinyl pyrazole compound of formula I, n nfrom a compound of formula III, wherein, R, R 1 and R 2 represent a group containing halogen group respectively and R 3 represents a perhaloalkyl.

    专利号:US-9029564-B2
    优先权日:2011-05-30
    标题:Process for synthesis of fipronil
    发明人：GHARDA KEKI HORMUSJI
    权利人:GHARDA KEKI HORMUSJI
    摘要:A process for preparation of Fipronil (i.e. 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoro-methylsulphinyl-pyrazole) is provided, which comprises oxidizing 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-tri-fluoromethylthio-pyrazole with sulfuric acid and hydrogen peroxide as oxidizing agent in the presence of a solvent such as ethylene dichloride, chlorobenzene.

    专利号:WO-2011107998-A1
    优先权日:2010-03-03
    标题 :Process for synthesis of fipronil

    专利号:RU-2045517-C1
    优先权日:1988-12-13
    标 题 :Method of synthesis of fluoroperhalogenalkylthioesters

    专利号:AU-2010100462-A4
    优先权日:2010-03-03
    标题:A process for the synthesis of Fipronil

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    主要参考文献

    参考标题:Substrate-Controlled [5+1] Annulation Of 5-Amino-1H -Phenylpyrazoles With Alkenes: Divergent Synthesis Of Multisubstituted 4,5-Dihydropyrazolo[1,5-A ]Quinazolines
    作者:Xunyuan Jiang,Xiaoyi Wei,Fei Lin,Zhixiang Zhang,Guangkai Yao,Shuai Yang,Weijing Zhao,Chen Zhao,Hanhong Xu |发布日期:2020.7.15
    摘要:With C=c Double Bonds As One‐carbon Synthons, An Efficient [5+1] Hetero‐annulation Of 5‐amino‐1H‐phenylpyrazoles With Electron‐deficient Olefinic Esters Was Developed, Allowing The First And Divergent Synthesis Of 5,5‐disubstituted 4,5‐dihydropyrazolo[1,5‐a ]Quinazolines.

    合成参考文献


    摘要:S60 | SWISSPEST19 | Swiss Pesticides and Metabolites from Kiefer et al 2019 | DOI:10.5281/zenodo.3544759
    摘要:S100 | PFASREACH | List of PFAS identified in REACH 2019 | DOI:10.5281/zenodo.7426856
    摘要:S69 | LUXPEST | Pesticide Screening List for Luxembourg | DOI:10.5281/zenodo.3862688
    摘要:S66 | EAWAGTPS | Parent-Transformation Product Pairs from Eawag | DOI:10.5281/zenodo.3754448
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