CAS: 106-95-6; Allyl Bromide

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CAS号107-18-6 烯丙醇 | CAS号107-05-1 氯丙烯 | CAS号109-64-8 1,3-二溴丙烷 | CAS号18146-00-4 三甲基烯丙氧基硅烷 | CAS号108-48-5 2,6-二甲基吡啶 | CAS号118668-51-2 1,3-dibromo-2-(... | CAS号76065-47-9 allylbromobis(4... | CAS号498-62-4 3-噻吩甲醛 | CAS号100-39-0 溴化苄 | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号10542-47-9 N,N-bis(prop-2-... | CAS号107428-06-8 2-烯丙基-2-(2-丙炔-1... | CAS号109523-70-8 4-hydroxy-1-pro... | CAS号111865-53-3 N-benzyl-6-meth... | CAS号105598-38-7 4-prop-2-enoxyb... | CAS号105598-68-3 1,4-bis(allylox... | CAS号106928-50-1 甲基-2-B°C-氨基-4-戊烯酸 | CAS号10484-09-0 水杨酸烯丙酯 | CAS号105535-09-9 1-but-3-enyl-4-... | CAS号1082287-99-7 2,3,3-trimethyl...

3-溴丙炔置于哌嗪,氢气体系中,用 乙醇 用作溶剂,100.0 °C,600.01 Kpa 条件下,反应 24.0H,反应生成3-溴丙烯
参考文献:沮丧的路易斯对通过h 2杂种活化作用,金-配体催化炔烃选择性加氢成顺式烯烃
标题:沮丧的路易斯对通过h 2杂种活化作用,金-配体催化炔烃选择性加氢成顺式烯烃
摘要:炔烃的选择性加氢为烯烃是化学工业中重要的合成方法.通常使用包含表面改性剂(例如铅和银)的钯催化剂来完成.在这里,我们报道金纳米颗粒上含氮碱基的吸附导致沮丧的lewis对界面,该界面杂化地激活h 2,从而实现了出乎意料的高氢化活性.如此形成的紧密离子对可以选择性地转移至炔烃,生成顺式异构体;反之亦然.这种行为是由静电相互作用控制的.活性与h 2相关离解能,这取决于配体的碱性及其在氢活化下的重组.高表面占有率和强的au原子-配体相互作用可能会影响活性位点的可及性和稳定性,从而使活性预测成为多参数函数.从机理上讲,发现具有两个杂原子的含氮碱基的促进作用是提高金活性的一种策略.
Doi:10.1021/acscatal.6B03441

专利信息

专利号:US-9920084-B2
优先权日:2011-08-23
标题 :Ionic tags for synthesis of oligoribonucleotides
发明人：DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK-HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER
权利人:DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV; HONG KONG POLYTECHNIC UNIV
摘要:The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

专利号:US-11236029-B2
优先权日:2019-05-17
标题 :Synthesis of a triangulene ring system and derivatives thereof
发明人：JOHNSON RICHARD PETER; HOLT CARTER J
权利人:THE UNIV OF NEW HAMPSHIRE; UNIV NEW HAMPSHIRE
摘要:A three step synthesis of the 8,12-dihydro-4H-dibenzo[cd,mn]pyren-3a 2 -ylium cation (triangulenium cation) is effected by cascade cyclization of a tetra-benzyl alcohol precursor in triflic acid solution. This cation is easily observed by NMR and optical spectroscopy. Quenching of the cation into basic solutions or by hydride transfer from triethylsilane provides access to stable dihydro and tetrahydro[3]triangulenes. This route makes several [3]triangulene precursors more readily available for development of new applications in the field of molecular electronics.

专利号:WO-2021260722-A1
优先权日:2020-06-21
标 题:Design, synthesis of novel oxyindole inhibitors of denv rna dependent rna polymerase
发明人：GUNDLA RAMBABU; ASTHANA SHAILENDRA; BHATTACHARYYA SANKAR; MADDIPATI VENKATANARAYANA CHOWDARY; MITTAL LOVIKA; KAUR JASKARAN; RAWAT YOGITA
权利人:TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE; GANDHI INSTITUTE OF TECH AND MANAGEMENT
摘要:The present invention is drawn to novel compounds of formula I, II and III, including any conformational isomeric form, salts and solvates for inhibition of DENV RNA dependent and RNA polymerase. The present invention also discloses a process of synthesis of the compounds, compositions comprising the said compounds and use of the compounds and treatment comprising the compounds of the present invention.

专利号:US-11566040-B2
优先权日:2019-01-28
标题:Synthesis of O-antigen oligosaccharide compounds of Helicobacter pylori serotype O2
发明人：YIN JIAN; HU JING; LIU ZHONGHUA; QIN CHUNJUN
权利人:UNIV JIANGNAN
摘要:Disclosed is synthesis of an O-Antigen oligosaccharide compound of Helicobacter pylori serotype O2, belonging to the field of organic synthesis. The disclosure obtains O-antigen disaccharide to tetracosasaccharide of Helicobacter pylori serotype O 2 by chemical synthesis. A chemical synthesis method which is quite conducive to production of a glucose-α-lglucosidic bond is developed in the disclosure by a protectant strategy, temperature effect, solvent effect, and additive effect. The method is applied in synthesis of an O-antigen oligosaccharide compound of Helicobacter pylori serotype O2 assembled with an amino linking arm. A saccharide conjugate can be prepared from the synthesized O-antigen oligosaccharide compound of Helicobacter pylori serotype O2 assembled with an amino linking arm together with a carrier protein for immunology researches, playing an important role in preventing and treating Helicobacter pylori.

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.