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📜十一烷酸置于戊醇,Sodium,Thorium Dioxide体系中,化学反应生成2-十三醇
参考文献:Dominant Role Of An Endothelium-Derived Hyperpolarizing Factor (Edhf)-Like Vasodilator In The Ciliary Vascular Bed Of The Bovine Isolated Perfused Eye
标题:Dominant Role Of An Endothelium-Derived Hyperpolarizing Factor (Edhf)-Like Vasodilator In The Ciliary Vascular Bed Of The Bovine Isolated Perfused Eye
摘要:以下是中文翻译: 评估了来自内皮的no,前列环素和内皮源性超极化因子(edhf)在介导乙酰胆碱和缓激肽引发的血管舒张反应中的作用,实验对象为牛孤立灌注眼的睫状血管床. 乙酰胆碱或缓激肽引起的血管舒张不受no合成酶抑制剂(l-Name,100 μm)或环氧化酶抑制剂(flurbiprofen,30 μm)的影响,但在给予高浓度kcl(30 Mm)或使用洗涤剂chaps(0.3%,2 Min)破坏内皮后,血管舒张几乎完全消失. 乙酰胆碱诱导的血管舒张不受atp敏感型k+通道抑制剂(glibenclamide,10 μm)的影响,但在给予非选择性k+通道抑制剂(tea,10 Mm)后显著减弱. 小导电钙敏感型k+通道(sk+ca)抑制剂(apamin,100 Nm)和大导电钙敏感型k+通道(bk+ca)抑制剂(iberiotoxin,50 Nm)对乙酰胆碱诱导的血管舒张无显著影响.相比之下,中/大导电钙敏感型k+通道抑制剂(charybdotoxin,50 Nm)强烈阻断了这些血管舒张反应,并揭示了血管收缩反应. Apamin(100 Nm)与sub-Threshold浓度的charybdotoxin(10 Nm)组合显著减弱乙酰胆碱诱导的血管舒张,而apamin(100 Nm)与iberiotoxin(50 Nm)组合无影响. 综上所述,高浓度kcl,Charybdotoxin或apamin与sub-Threshold浓度charybdotoxin的组合对血管舒张的强烈阻断,强烈表明牛孤立灌注眼中的血管舒张是由edhf介导的. British Journal Of Pharmacology (2001) 134,912-920; Doi:10.1038/sj.Bjp.0704332
Doi:10.1038/sj.Bjp.0704332

专利信息

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:WO-2014108526-A1
优先权日:2013-01-11
标题 :Synthetic process for the manufacture of pipecolidepsin compounds
发明人：PELAY GIMENO MARTA; GARCÃ?A-RAMOS YESICA; TULLA PUCHE JUDIT; ALBERICIO PALOMERA FERNANDO; MARTÃ?N LÓPEZ M JES S
权利人:PHARMA MAR SA
摘要:(I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , n and Y are as described. The invention provides a process for the synthesis of complex pipecolidepsin and related compounds of formula (I), opening a new field of compounds with useful biological properties. The invention also provides intermediates, useful in the synthesis of compounds of formula (I).

专利号:US-10017465-B2
优先权日:2014-08-12
标 题 :Method for producing astaxanthin from astacin
发明人：Schäfer Bernd; SIEGEL WOLFGANG
权利人:BASF SE
摘要:The invention relates to a method for the non-stereoselective and also for the stereoselective synthesis of astaxanthin from astacin. For this purpose, a reducing agent is used selected from the group of hydrogen, a secondary alcohol, formic acid and also the salts of formic acid or from a mixture of at least two representatives of the compound classes stated above. The invention further relates to the use of astacin as starting compound for the synthesis of astaxanthin.

专利号:US-2002010339-A1
优先权日:1998-05-26
标 题:Method for synthesis of halopyridyl-acyclopentane derivative and intermediate thereof

专利号:CN-102924707-A
优先权日:2012-11-22
标 题 :Catalyst for Synthesis of Block Polyether and Its Application

专利号:CN-102924709-B
优先权日:2012-11-22
标题:The method of synthesis block polyether