CAS: 90940-54-8; D-Homophenylalanine Ethyl Ester Hydrochloride
该化合物是化学化合物,其结构特征包括苯环,丁诺酸味,乙酯功能组以及氨基氨基化合物,该化合物一般是白色至白外晶状固体,由于存在盐盐形式,可溶于水中,与自由基相比,盐的溶性会提高;氨基酸类的存在表明生物活动具有潜力,使其对药物应用感兴趣;其立体化学学,如(R)项的称谓,意味着原子的具体空间安排能够影响其再活性和与生物系统的互动;作为盐盐,该物质通常用于制剂,以提高稳定性和生物利用率;总体而言,该混合物的特性使其与医药化学和相关领域相关,其特性可用于治疗目的.
- 英文名称D-Homophenylalanine Ethyl Ester Hydrochloride
- 中文名称D-高苯丙氨酸乙酯盐酸盐
- IUPAC名称ethyl (R)-2-amino-4-phenylbutanoate hydrochloride
- 其它别名D-Homophenylalanine Ethyl Ester Hcl; D-Homophenylalanine Ethyl Ester, Hcl; Ethyl (2R)-2-Amino-4-Phenylbutanoate; Hydrochloride; D-Homophenylalanine Ethyl Ester Hydrochloride; D-Homophenylalanine E
- CAS编号90940-54-8
- MFCD编号:MFCD03095466
- EINECS号:823-308-4
- 分子式:C12H18ClNO2分子量:243.73
- 产品CID: 1943546
- 产品分类有机原料→生命科学→氨基酸及其衍生物→苯丙氨酸及其衍生物
相似化合物
90891-21-7 1012-05-1 82795-51-5MSDS等安全信息
- GHS符号GHS07
- 危险类别急性毒性 类别4(经口)
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2A - 警示词Warning
- 危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- UN编号NONH for all modes of transport
- 危险品标志Xi
- 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- WGK Germany3
欧盟法规
C&L通报上下游产品
CAS号146912-63-2 (2S)-2-hydroxy-... | CAS号71-43-2 苯 | CAS号115016-95-0 (S)-2-羟基-4-苯丁酸 | CAS号125639-64-7 (S)-4-苯基-2-羟基丁酸乙酯合成工艺路线路线简述
- 46460-24-6 = 90940-54-8 + 943-73-7
反应条件:1.1 Catalysts: Triacylglycerol Lipase Solvents: Water
标题:Kinetic Resolution Of Amino Acid Esters Catalyzed By Lipases
作者:Houng,Jer-Yiing; Wu,May-Ling; Chen,Shui-Tein
参考文献:Chirality 日期:1996 卷标:8(6) 页码:418-422]
= 90940-54-8
反应条件:1.1 Reagents: Zinc,Ammonium Chloride Solvents: Ethanol,Water1.2 Reagents: Ammonium Hydroxide Solvents: Ethyl Acetate,Water1.3 Reagents: Hydrochloric Acid
标题:A Practical Synthesis Of Ethyl (R)- And (S)-2-Hydroxy-4-Phenylbutanoate And D-Homophenylalanine Ethyl Ester Hydrochloride From L-Malic Acid
作者:Lin,W.-Q.; He,Z.; Jing,Y.; Cui,X.; Liu,H.; Et Al
参考文献:Tetrahedron: Asymmetry 日期:2001 卷标:12(11) 页码:1583-1587
📜Ethyl (R)-2-Azido-4-Phenylbutanoate置于氯化铵,锌体系中,用 乙醇,水 作为反应溶剂,化学反应 0.17H,以87%的收率获得产物d-高苯丙氨酸乙酯盐酸盐
参考文献:A Practical Synthesis Of Ethyl (R)-And (S)-2-Hydroxy-4-Phenylbutanoate And D-Homophenylalanine Ethyl Ester Hydrochloride From L-Malic Acid
标题:A Practical Synthesis Of Ethyl (R)-And (S)-2-Hydroxy-4-Phenylbutanoate And D-Homophenylalanine Ethyl Ester Hydrochloride From L-Malic Acid
摘要:With The Readily Available L-Malic Acid As Starting Material. Both Enantiomers Of Ethyl 2-Hydroxyl-4-Phenylbutanoates And D-Homophenylalanine Ethyl Ester Hydrochloride Were Prepared Conveniently In Excellent Optical Purity And 64. 53 And 49% Overall Field. Respectively. (C) 2001 Published By Elsevier Science Ltd.
DOI:10.1016/s0957-4166(01)00285-3
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2909110000-乙醚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
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主要参考文献
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-958.合成参考文献
合成方法参考DOI号:10.1016/S0957-4166(01)00285-3
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