CAS: 89490-05-1; Cyclohex-1-En-1-Ylboronic Acid

相似化合物

141091-37-4 865869-28-9 850567-92-9

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CAS号141091-37-4 环己烯-1-硼酸频哪醇酯 | CAS号694-51-9 1-fluor°Cyclohexene | CAS号418760-99-3 2-(cyclohexen-1...

1-环己烯基-1-甲酸甲酯置于溴,碘,Magnesium,Potassium Hydroxide体系中,用 四氢呋喃,二氯甲烷,水 作为反应溶剂,化学反应 0.5H,反应生成 环己烯-1-基硼酸
参考文献:一种制备环戊(己)烯-1-硼酸频那醇酯的方法
标题:一种制备环戊(己)烯-1-硼酸频那醇酯的方法
摘要:本发明公开了一种从环戊(己)烯‑1‑羧酸甲酯出发,经过三步连续操作制备环戊(己)烯‑1‑硼酸频那醇酯的方法.首先原料经过碱解形成相应的烯基‑1‑羧酸;随后与溴素加成,接着在dbu或dmap存在下,同时发生消除和脱羧反应生成环戊(己)烯‑1‑溴;最后环戊(己)烯‑1‑溴,甲氧基硼酸频那醇酯在金属镁存在下一锅法成酯得到环戊(己)烯‑1‑硼酸频那醇酯.本发明所提供的工艺方法连续性强,操作简便,无需低温反应,同时也可以高纯度得到环戊(己)烯‑1‑澳中间体,满足市场上需求.一锅法格氏/酯化,操作上更便捷,副产物少,产品更容易精馏提纯.

专利信息

专利号:WO-2023086801-A1
优先权日:2021-11-09
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-12428425-B2
优先权日:2020-05-04
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; PANTELEEV JANE; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-9670234-B2
优先权日:2014-07-10
标题 :Metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2-substituted-4-oxy-cyclopent-2-en-1-ones yielding prostaglandins and prostaglandin analogs
发明人：HENSCHKE JULIAN PAUL; WU PING-YU; WU HSYUEH-LIANG; WEN WEN-HSIEN
权利人:SCINOPHARM TAIWAN LTD
摘要:This invention provides a novel method for the preparation of 2,3-disubstituted -4-oxy-cyclopentan1-one compounds that are useful for the synthesis of prostaglandins and prostaglandin analogs of industrial relevance. The method comprises the metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2-substituted -4-oxy-cyclopent-2-en-1-ones. This method relies on the use of less toxic, easily-handled reagents, and can be performed under milder conditions than offered by some conventional methods, affording 2,3-disubstituted-4-oxy-cyclopentan-1-one compounds enantio- and diastereoselectively, which are precursors to the said prostaglandin and prostaglandin analogs, in high yield.

专利号:US-2011021532-A1
优先权日:2008-04-22
标题 :Novel substituted heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：POWELL DAVID; LEBRUN MARIE-EVE; BHAT SATHESH; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

专利号:CN-112745244-B
优先权日:2019-10-30
标 题 :A kind of intermediate of siponimod and its synthesis method

专利号:WO-2024226703-A2
优先权日:2023-04-27
标题:Asymmetric synthesis and diversification of a stabilized salvinorin a scaffold