CAS: 84-66-2; Diethyl Phthalate

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CAS号762-21-0 丁炔二酸二乙酯 | CAS号123-73-9 2-丁烯醛 | CAS号64-17-5 乙醇 | CAS号1041479-60-0 bis(2-(ethoxyca... | CAS号201230-82-2 carbon monoxide | CAS号75-03-6 碘乙烷 | CAS号88-99-3 邻苯二甲酸 | CAS号1829-28-3 2-碘苯甲酸乙酯 | CAS号141-52-6 乙醇钠 | CAS号85-44-9 苯酐 | CAS号606-23-5 1,3-茚满二酮 | CAS号31519-22-9 1,4-二羟基-2-萘甲酸 | CAS号93-89-0 苯甲酸乙酯 | CAS号14570-43-5 2-propylindene-... | CAS号38228-99-8 N,N'-二苄基邻苯二甲酰胺 | CAS号62351-79-5 diethyl 3-nitro... | CAS号2050-19-3 二乙基-4-硝基苯-1,2-二羧酸 | CAS号22135-01-9 1H-Indene-1,3(2... | CAS号21889-13-4 2-[[4-(二甲基氨基)苯基... | CAS号95-47-6 邻二甲苯

Diethyl Cyclohex-4-Ene-1,2-Dicarboxylate置于palladium (II) Trifluoroacetate,Sodium Anthraquinone-2-Sulfonate,氧气,Magnesium Sulfate体系中,用 氯苯 作为反应溶剂,110.0 °C,101.33 Kpa 条件下,反应 24.0H,以89%的收率获得产物邻苯二甲酸二乙酯
参考文献:钯催化环己烯有氧氧化脱氢反应生成取代芳烃衍生物
标题:钯催化环己烯有氧氧化脱氢反应生成取代芳烃衍生物
摘要:钯(II)催化剂体系已被确定用于取代环己烯有氧脱氢成相应的芳烃衍生物.使用蒽醌-2-磺酸钠(ams)作为助催化剂可提高产品收率.反应中可以耐受多种官能团,并描述了该方法的范围和局限性.展示了环己烯催化脱氢反应生成基于邻苯二甲酰亚胺的 Trpa1 活性调节剂的有效途径.
DOI:10.1021/ja512770U

专利信息

专利号:US-7759520-B2
优先权日:1996-11-27
标 题 :Synthesis of selective androgen receptor modulators
发明人：DALTON JAMES T; MILLER DUANE D; YIN DONGHUA; HE YALI
权利人:UNIV TENNESSEE RES FOUNDATION
摘要:The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.

专利号:US-6995284-B2
优先权日:2000-08-24
标题 :Synthesis of selective androgen receptor modulators
发明人：DALTON JAMES T; MILLER DUANE D; HE YALI; YIN DONGHUA
权利人:UNIV TENNESSEE RES FOUNDATION
摘要:The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.

专利号:US-5166110-A
优先权日:1989-12-22
标 题 :Process for the synthesis of ziegler-type catalytic solids or solid constituents of the same
发明人：BRUN CLAUDE
权利人:ATOCHEM ELF SA
摘要:A process is provided for the synthesis of a solid Ziegler catalyst or of a transition metal solid constituent thereof, which entails preparing the solid catalyst or constituent thereof as a suspension in an inert liquid medium by contacting precursors or ingredients of the catalyst or of the constituent in the inert liquid medium in one or more steps, and drying the suspension, and collecting the catalyst or constituent thereof; and wherein the process is conducted in a single multi-function reactor having a longitudinal axis and which can pivot around an axis which intersects perpendicularly with this axis.

专利号:US-9040444-B2
优先权日:2009-12-22
标 题:Semi continuous process for the synthesis of a catalyst for use in the manufacture of polyolefins
发明人：SINGALA KAMLESH; SINGH SAURABH; GUPTA VIRENDRAKUMAR
权利人:SINGALA KAMLESH; SINGH SAURABH; GUPTA VIRENDRAKUMAR; RELIANCE IND LTD
摘要:A semi-continuous process and system thereof, for the synthesis of a narrow particle size distribution Zeigler Natta procatalyst for use in the manufacture of polyolefins. The process comprises: (a) mixing a reaction mixture containing a titanium compound; (b) charging a first reactor with said reaction mixture; (c) removing excess reactants from said first reactor as a filtrate; (d) feeding said filtrate to at least one further reactor; and continuously removing excess reactants from said at least further reactor.

专利号:US-9597327-B2
优先权日:2005-05-25
标 题:Synthesis of (R)-N-methylnaltrexone
发明人：DOSHAN HAROLD D; PEREZ JULIO
权利人:PROGENICS PHARM INC
摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.

专利号:US-11745159-B2
优先权日:2017-10-20
标题:Heated nanowells for polynucleotide synthesis
发明人：MARSH EUGENE P; INDERMUHLE PIERRE F; PECK BILL JAMES
权利人:TWIST BIOSCIENCE CORP
摘要:Defined sequence RNA synthesis by 3′→5′ direction is now well established and currently in use for synthesis and development of vast variety of therapeutic grade RNA and Si RNA etc. A number of such synthetic RNA requires a modification or labeling of 3′-end of an oligonucleotide. The synthesis of 3′-end modified RNA requiring lipophilic, long chain ligands or chromophores, using 3′→5′ synthesis methodology is challenging, requires corresponding solid support and generally results in low coupling efficiency and lower purity of the final oligonucleotide in general because of large amount of truncated sequences containing desired hydrophobic modification. We have approached this problem by developing reverse RNA monomer phosphoramidites for RNA synthesis in 5′→3′-direction. They lead to very clean oligonucleotide synthesis allowing for introduction of various modifications at the 3′-end.