CAS: 84-17-3; 4,4'-(Hexa-2,4-Diene-3,4-Diyl)Diphenol

该化合物是一种合成的非类固醇雌激素,与二乙基二乙基溴(DES)具有结构相似性.主要用于激素疗法和研究应用,因为其具有雌激素活性.复合物与雌激素受体具有高度的粘合性,能够有效地调制荷尔蒙途径.其稳定性和可预测的药代动因特征使其适合于受控实验和治疗用途.二亚氏激素往往用于涉及雌激素依赖性生理过程或病理的研究.它作为精细的雌激素模拟物,作为生物化学和药理研究的可靠参考化合物.由于其荷尔蒙效应和潜在的环境影响,需要妥善处理.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

diethyl ether chloroform diethylstilbestrol lead(IV) tetraacetateindenestrol A hexestrol dl-hexestrol Bis-(2-chloro-ethyl)-carbamic acid 4-[(E)-2-{4-[bis-(2-chloro-ethyl)-carbamoyloxy]-phenyl}-1-eth-(Z)-ylidene-but-2-enyl]-phenyl ester

合成工艺路线路线简述

    📜Dienestrol Dimethyl Ether置于氢氧化钾体系中,化学反应生成 双烯雌酚
    参考文献:Effect Of Low-Fat And/or Low-Energy Diets On Anthropometric Measures In Participants Of The Women's Diet Study
    标题:Effect Of Low-Fat And/or Low-Energy Diets On Anthropometric Measures In Participants Of The Women's Diet Study
    摘要:Objective: To Compare The Effects Of Low-Fat,Low-Energy And Combination Low-Fat/low-Energy Intervention On Changes In Six Anthropometric Measures In Caucasian And African-American Free-Living Women.Methods: The Effects Of Dietary Counseling Strategies For Fat And/or Energy Reduction Were Examined On Anthropometric Measures In 86 Pre-Menopausal Women,Average Bmi Of 28 Kg/m(2),Who Participated In A 12-Week Intervention Trial Called The Women'S Diet Study. The Dietary Goals Were 1510 Of Energy From Fat And/or 25% Reduction In Energy Intake,Relative To Reported Baseline Intake,Using A 2 X 2 Factorial Design. Analysis Of Covariance Models Were Constructed To Evaluate Changes In Anthropometric Measures Over The 12 Weeks Of Study.Results: The Biggest Difference By Race Was In Women Who Were Relatively Heavier At Baseline,In Which Case African-American Women Lost Significantly Less Weight But Decreased Their Waist:Hip Ratio To A Significantly Greater Extent Than Caucasian Women. With Regard To The Effects Of Diet Arm,Weight Loss Varied Depending On Baseline Weight,And In Women With Higher Baseline Weights,The Combination Low-Fat/low-Energy Diet Resulted In The Most Weight Loss (6.7 Kg,P < 0.05). Decreases In The Other Anthropometric Measures At Week 12 Were More Uniform Across Diet Arms And Did Not Depend On Baseline Values. After Controlling For Previous Weight History And Race,The Decreases In Bmi,Percent Body Fat And Waist Circumference After 12 Weeks Were Statistically Equivalent With The Low-Fat,Low-Energy Or Combination Low-Fat/low-Energy Diets. The Relatively Greater Decreases In Percent Body Fat And Waist Circumference With The Combination Diet Versus The Low-Fat Or Low-Energy Diets Were Not Statistically Significant.Conclusion: The Low-Fat,Low-Energy And Combination Diets All Resulted In Similar And Statistically Significant Decreases In Bmi,Percent Body Fat And Waist Circumference Over 12 Weeks Of Intervention. The Extent Of Weight Loss,However,Varied Depending On Baseline Weight,And The Combination Diet Was The Only Intervention To Result In Significant Weight Loss For Women Who Were Heavier At Baseline. This Indicates That,Although There May Be An Advantage For Reducing Dietary Fat In Initially Heavier Women,Any Of These Counseling Strategies Could Be Effective For Improving Anthropometric Predictors Of Health Risks Associated With Overweight Status. This Is Useful Since Flexibility In Dietary Choices May Facilitate Adherence To Dietary Counseling In Some Individuals.
    DOI:10.1080/07315724.2002.10719192

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Hu WY, Kang XJ, Zhang C, Yang J, Ling R, Liu EH, Li P. Packed-fiber solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:7-13. doi: 10.1016/j.jchromb.2014.02.036. Epub 2014 Mar 2. doi: 10.1039/c1an15494j. Epub 2011 Oct 12. doi: 10.1186/1471-2407-9-358.
    5: Dickson LC, MacNeil JD, Reid J, Fesser AC. Validation of screening method for residues of diethylstilbestrol, dienestrol, hexestrol, and zeranol in bovine urine using immunoaffinity chromatography and gas chromatography/mass spectrometry. J AOAC Int. 2003 Jul-Aug;86(4):631-9.

    合成参考文献


    参考文献:10.1016/j.jmgm.2006.01.007
    摘要:Li H, Ung CY, Yap CW, Xue Y, Li ZR, Chen YZ. Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. Journal of Molecular Graphics and Modelling. 2006 Nov;25(3):313–23. doi: 10.1016/j.jmgm.2006.01.007.
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