82998-57-0 = 82998-57-0 反应条件:1.1 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethylformamide,Dichloromethane; Overnight,25 °C 标题:Development Of Resin-To-Resin Transfer Reactions (Rrtr) Using Sonogashira Chemistry 作者:Tulla-Puche,Judit; Et Al 参考文献:Tetrahedron 日期:2005 卷标:61(8) 页码:2195-2201]
99-94-5 = 82998-57-0 反应条件:1.1 Reagents: Ammonium Iodide,Rel-(3R,5R)-3,5-Bis(Hydroperoxy)-3,5-Dimethyl-1,2-Dioxolane Solvents: Acetic Acid; 5 H,Rt1.2 Reagents: Sodium Sulfite Solvents: Water; 10 Min,Rt 标题:Regioselective Bromination And Iodination Of Aromatic Substrates Promoted By Trans-3,5-Dihydroperoxy-3,5-Dimethyl-1,2-Dioxolane 作者:Azarifar,Davood; Et Al 参考文献:Journal Of The Iranian Chemical Society 日期:2012 卷标:9(3) 页码:321-326]
99-94-5 = 82998-57-0 [标题:Reaction Conditions 标题:Potassium Permanganate - Convenient Oxidizer For Direct Iodination Of Aromatic Compounds 作者:Chaikovskii,V. K.; Et Al 参考文献:Zhurnal Prikladnoi Khimii (Sankt-Peterburg 日期:1984 卷标:57(1) 页码:134-7]
99-94-5 = 82998-57-0 反应条件:1.1 Reagents: Iodine,Sodium Periodate Solvents: Acetic Acid,Acetic Anhydride1.2 Reagents: Sulfuric Acid1.3 Reagents: Sodium Sulfite Solvents: Water 标题:Iodination Of Both Deactivated And Activated Arenes With Sodium Periodate Or Sodium Iodate As The Oxidants 作者:Lulinski,Piotr; Et Al 参考文献:Bulletin Of The Chemical Society Of Japan 日期:2000 卷标:73(4) 页码:951-956]
165803-89-4 = 82998-57-0 反应条件:1.1 Reagents: Potassium Hydroxide,Oxygen Catalysts: Cobalt (Carbon Supported) Solvents: Water; 24 H,10 Bar,110 °C 标题:A "Universal" Catalyst For Aerobic Oxidations To Synthesize (Hetero)Aromatic Aldehydes,Ketones,Esters,Acids,Nitriles,And Amides 作者:Senthamarai,Thirusangumurugan; Et Al 参考文献:Chem 日期:2022 卷标:8(2) 页码:508-531]
2458-12-0 = 82998-57-0 反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water1.2 Reagents: Potassium Iodide,Cuprous Iodide Solvents: Water 标题:The Synthesis Of 3-Hydroxymethyldibenzo[b,F]Thiepin 5,5-Dioxide,A Prostaglandin Antagonist 作者:Hands,David; Et Al 参考文献:Journal Of Heterocyclic Chemistry 日期:1986 卷标:23(5) 页码:1333-7
专利号:WO-2013117440-A1 优先权日:2012-02-09 标 题 :Synthesis of water-soluble phosphine oxides by pd/c-catalyzed p-c coupling in water 发明人:RANOCCHIARI MARCO; RUMMELT STEPHAN; VAN BOKHOVEN JEROEN A 权利人:SCHERRER INST PAUL 摘要:Cross-coupling between diphenylphosphine oxide and halogenated benzoic acids catalyzed by Pd/C in water is a green, simple and fast protocol to obtain water-soluble tertiary phosphine oxides without the addition of ligands and additives. Low reaction times, microwave irradiation, and high substrate scope make this method general and excellent for lab- and large-scale synthesis without the need to use organic solvents for neither reaction nor workup.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-6664282-B2 优先权日:1999-09-17 标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds 发明人:ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TORREY PINES INST 摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.
专利号:US-2024400552-A1 优先权日:2016-11-11 标题 :Heterocyclic modulators of lipid synthesis 发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S 权利人:SAGIMET BIOSCIENCES INC 摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).
专利号:US-11622968-B2 优先权日:2011-03-08 标 题:Heterocyclic modulators of lipid synthesis 发明人:BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S 权利人:SAGIMET BIOSCIENCES INC 摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).
专利号:US-5856107-A 优先权日:1997-02-04 标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein 发明人:OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TREGA BIOSCIENCES INC 摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.
参考标题:Design And Synthesis Of Novel Dasatinib Analogues 作者:G. Buchappa,K. Durgaprasad,B. Suneelkumar,P. Baby Rani,K. Ravi Babu,A.K.S. Bhujanga Rao,P. Aparna 摘要:Design, Synthesis, Characterization And In Vitro Biological Assay Of A Series Of Novel Carboxylic Acid And Amino Acid Analogs Of Dasatinib (1) As Anticancer Agents Are Reported. Some Of The Synthesized Analogs Were Identified As Potent Src/abl Kinase Inhibitors With Greater Antiproliferative Activity Against K652 And T315I Cancer Cell Lines. The Synthetic Process Involves Condensation Of N-(2-Chloro-6-Methylphenyl)-2-[[6-[4(-1-Pipearazinyl]-2-Methyl-4-Pyrimidinyl]Amino]-5-Thiazolecarboxamide With Carboxylic Acids In The Presence Of Dicyclohexylcarbodiimide And Oxyma In Organic Solvent Medium. Compounds Were Characterized And Tested For Anticancer Activity On Leukemia Cancer Cell Lines K562 And Baf3/t315. Analogues Of Lactic Acid, Mandalic Acid, Leucine And Proline Have Shown Promising Antiproliferative Activity Compared To Dasatinib.
合成参考文献
摘要:Li, D.-D.; Wang, G.-W., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 391.