CAS: 756520-66-8; 1-(2,6-Dichloro-3-Fluorophenyl)Ethanol

上下游产品

CAS号330156-50-8 (R)-1-(2,6-二氯-3... | CAS号877397-65-4 (s)-1-(2,6-二氯-3... | CAS号877400-66-3 3-(1-(2,6-DICHL... | CAS号1365267-27-1 恩沙替尼(X-376) | CAS号756503-69-2 5-溴-3-(1-(2,6-二... | CAS号756520-67-9 3-(1-(2,6-二氯-3-... | CAS号756521-08-1 3-(1-(2,6-二氯-3-...

📜2,4-二氯氟苯置于正丁基锂体系中,用 四氢呋喃 作为反应溶剂,化学反应 33.0H,反应生成 1-(2,6-二氯-3-氟苯基)乙醇
参考文献:Ep3825314
标题:Ep3825314

专利信息

专利号:US-7465842-B2
优先权日:2004-08-26
标 题 :Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
发明人：KUNG PEI-PEI; MARTINEZ CARLOS; TAO JUNHUA
权利人:AGOURON PHARMA
摘要:The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a combination of enzymatic resolution, chemical esterification and chemical hydrolysis with inversion of 1-(2,6-dichloro-3-fluorophenyl)ethyl esters or stereoselective bio-reduction of 2,6-dichloro-3-fluoro-acetophenone with a biocatalyst such as an enzyme or a microorganism. The chiral (S)-enantiomer can be used in the synthesis of certain enantiomerically enriched, ether linked 2-aminopyridine compounds that potently inhibit auto-phosphorylation of human heptocyte growth factor receptor.

专利号:CN-108285908-B
优先权日:2017-12-26
标题 :A kind of method for immobilized double enzyme catalyzed synthesis of (S)-1-(2,6-dichloro-3-fluoro-phenyl)ethanol

专利号:CN-112125841-A
优先权日:2020-10-23
标题:A new method for the synthesis of crizotinib intermediates

专利号:US-8785632-B2
优先权日:2004-08-26
标 题:Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE
权利人:CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE; AGOURON PHARMA; PFIZER
摘要:Enantiomerically pure compound of formula 1 n nare provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

专利号:US-2012329826-A1
优先权日:2010-03-03
标 题:Substituted-5-aminopyrrolo/pyrazolopyridines
发明人：LI AN-HU; GUPTA RAMESH C; MULVIHILL MARK J; RAI ANAND NARAIN; WANG JING
权利人:LI AN-HU; GUPTA RAMESH C; MULVIHILL MARK J; RAI ANAND NARAIN; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by RON and/or MET.

专利号:US-2006178374-A1
优先权日:2004-08-26
标 题 :Aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG J; FUNK LEE A; JIA LEI; KUNG PEI-PEI; MENG JERRY J; NAMBU MITCHELL D; PAIRISH MASON A; SHEN HONG; TRAN-DUBE MICHELLE
权利人:AGOURON PHARMA
摘要:Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.