CAS: 71030-11-0; (2E,7S,11S)-7,15,17-Trihydroxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(18),2,14,16-Tetraen-13-One

该化合物是属于非类类动物雌性激素化合物的甲状腺毒素,主要产自某些菌株,特别是富森氏菌中的菌株;它是素的衍生物,以其雌激素活动闻名,可扰乱动物和潜在人类的内分泌功能;Zearalenol的化学结构具有苯球和氢氧基,有助于其生物活动;它通常存在于被污染的农产品中,如谷物,并可能对牲畜健康造成危害,进而通过食物链对人类造成危害;该物质的特点是分子重量和有机溶剂溶解度相对较低,便于在各种矩阵中检测和分析;监管机构监测食物和饲料中的Zeararenol含量,以减轻其对健康的影响,强调食品安全的重要性以及农业实践中有效管理甲型毒素污染的必要性.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号42422-68-4 B-赤霉醇

合成工艺路线路线简述

    📜玉米烯酮置于dipotassium Hydrogenphosphate,Sodium Chloride体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,以60%的收率获得产物β-玉米赤霉烯醇
    参考文献:Microbial Transformation Of Zearalenone. 2. Reduction,Hydroxylation,And Methylation Products
    标题:Microbial Transformation Of Zearalenone. 2. Reduction,Hydroxylation,And Methylation Products
    摘要:
    DOI:10.1021/jo00238A008

    海关参考信息

    专利信息


    专利号:US-7553979-B2
    优先权日:2001-11-09
    标题:HSP90-inhibiting zearalanol compounds and methods of producing and using same
    发明人：KASIBHATLA SRINIVAS R; LE BRAZIDEC JEAN-YVES; MCHUGH SEAN KONRAD; BOEHM MARCUS F
    权利人:CONFORMA THERAPEUTICS CORP
    摘要:Zearalanol compounds are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various disorders. Methods of synthesis and use of such compounds are also described and claimed.

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    主要参考文献

    参考标题:Enantioselective Total Synthesis Of β-Zearalenol From (S)-Propylene Oxide
    作者:Ravindar Kotla,Adharvana Chari Murugulla,Radhakrishnamraju Ruddarraju,P. Aparna,Shobha Donthabakthuni,Gattu Sridhar |发布日期:2018.4.3
    摘要:Abstract The Total Synthesis Of 14-Membered Resorcylic Acid Macrolide, β-Zearalenol, Was Accomplished Starting From Commercially Available Enantiomerically Pure Propylene Oxide And Methyl 2,4-Dihydroxy-6-Methylbenzoate Using Grignard Reaction, Asymmetric Dihydroxylation, Yamaguchi Macrolactonization, And Ring-Closing Metathesis As Key Steps. Graphical Abstract

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1007/s00216-008-1943-x
    摘要:Schmidt K, Stachel C, Gowik P. Development and in-house validation of an LC-MS/MS method for the determination of stilbenes and resorcylic acid lactones in bovine urine. Analytical and Bioanalytical Chemistry. 2008 Mar 25;391(4):1199–210. doi: 10.1007/s00216-008-1943-x.
    参考文献:10.1007/s00216-008-2047-3
    摘要:Zougagh M, Téllez H, Sánchez A, Chicharro M, Ríos A. Validation of a screening method for rapid control of macrocyclic lactone mycotoxins in maize flour samples. Analytical and Bioanalytical Chemistry. 2008 Mar 28;391(2):709–14. doi: 10.1007/s00216-008-2047-3.
    参考文献:10.1007/s12550-014-0198-y
    摘要:Gutzwiller A, Gafner JL, Silacci P. Urinary zearalenone measured with ELISA as a biomarker of zearalenone exposure in pigs. Mycotoxin Res. 2014 Nov;30(4):187–90. doi: 10.1007/s12550-014-0198-y.
    参考文献:10.1007/s12550-014-0199-x
    摘要:Tan H, Hu Y, He J, Wu L, Liao F, Luo B, He Y, Zuo Z, Ren Z, Zhong Z, Peng G, Deng J. Zearalenone degradation by two Pseudomonas strains from soil. Mycotoxin Res. 2014 Nov;30(4):191–6. doi: 10.1007/s12550-014-0199-x.
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