CAS: 635-27-8; 5-Chloroquinoline

该化合物是一种杂交循环芳香化合物,在5位位置上以氯原子替代了一条quinoline骨架,这种结构改变增强了其作为有机合成,特别是制药和农用化学应用中多用途中间体的效用.氯代基体具有电子脱衣特性,有利于核循环替代反应,并能够进一步实现功能化.它的稳定性和再活性使得它对于构建复杂的分子,包括生物活性化合物和用于催化的离子体很有价值. 5-克罗洛基诺线还被用于开发荧光染色和协调综合体的材料科学.高纯度能确保研究和工业过程的一贯性.

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611-35-8 86-98-6 4964-77-6

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CAS号611-34-7 5-氨基喹啉 | CAS号108-42-9 间氯苯胺 | CAS号56-81-5 甘油 | CAS号124-40-3 二甲胺 | CAS号90225-09-5 5-Chloroquinoli... | CAS号6942-98-9 5-氯-8-硝基喹啉 | CAS号72995-16-5 5-氯-1,2,3,4-四氢喹啉 | CAS号90224-97-8 5-chloro-1-oxid... | CAS号59412-12-3 2,5-二氯喹啉 | CAS号5432-09-7 8-氨基-5-氯喹啉

合成工艺路线路线简述

    📜5-氨基喹啉置于盐酸,Sodium Nitrite,Copper(L) Chloride体系中,用 水 作为反应溶剂,化学反应 3.0H,反应生成 5-氯喹啉
    参考文献: 4,5,6,7-Tetrahydro-1 H-Pyrazolo[4,3-C]Pyridin-3-Amine Compounds As Cbp And/or Ep300 Inhibitors[fr] Composés 4,5,6,7-Tetrahydro-1 H-Pyrazolo[4,3-C]Pyridin-3-Amine Utilisés Comme Inhibiteurs De Cbp Et/ou De Ep300
    标题: 4,5,6,7-Tetrahydro-1 H-Pyrazolo[4,3-C]Pyridin-3-Amine Compounds As Cbp And/or Ep300 Inhibitors[fr] Composés 4,5,6,7-Tetrahydro-1 H-Pyrazolo[4,3-C]Pyridin-3-Amine Utilisés Comme Inhibiteurs De Cbp Et/ou De Ep300

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    专利信息


    专利号:US-5247081-A
    优先权日:1987-08-28
    标 题 :Protected biotin derivatives
    发明人：EDGE MICHAEL D
    权利人:ICI PLC
    摘要:Processes for the preparation of biotinylated polynucleotides and analogues thereof and protected intermediate products for use in such processes are described and claimed. The processes may be conveniently used in the automated synthesis of biotinylated polynucleotide on a DNA synthesizer. The polynucleotides so prepared may be used as labelled probes e.g. as diagnostic tools for clinical and research uses.

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    主要参考文献

    参考标题:Synthesis Of Cyclic Amidines From Quinolines By A Borane-Catalyzed Dearomatization Strategy
    作者:Vinh Do Cao,So Hwa Mun,Seo Ha Kim,Gyeong Un Kim,Hyung Guk Kim,Seewon Joung |发布日期:2020.1.17
    摘要:Herein Is The Development Of A New Synthetic Route To Cyclic Amidines From Quinolines. The Borane-Catalyzed 1,4-Hydrosilylation Of Quinoline Was Utilized For The Dearomatization Of The Quinolines. The Dearomatized Enamine Intermediate Was Subsequently Reacted With A Broad Range Of Organic Azides To Produce The Corresponding Cyclic Amidines (3,4-Dihydroquinolinimines) Via A [3 + 2] Cycloaddition Pathway

    合成参考文献


    摘要:Cui, H.; An, B.; Zhang, X., Science of Synthesis: Dearomatizations, (2026) .
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