专利号:US-9212118-B2 优先权日:2010-12-23 标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof 发明人:HUMLJAN JAN; MARAS NENAD 权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.
专利号:WO-2020185105-A1 优先权日:2019-03-14 标题:Improved method for the synthesis of pyrrolo[3,2-b]pyrroles 发明人:GRYKO DANIEL; TASIOR MARIUSZ; KOSZARNA BEATA; YOUNG DAVID C 权利人:INST CHEMII ORGANICZNEJ PAN 摘要:An improved method for the synthesis of pyrrolo[3,2- b ] pyrroles using iron (III) salts as a catalyst is disclosed.
专利号:US-7125983-B2 优先权日:2000-11-29 标题:L-nucleic acid derivatives and process for the synthesis thereof 发明人:IIZUKA HAJIME; TOGASHI KAZUHIKO; SUZUKI TSUNEJI 权利人:MITSUI CHEMICALS INC 摘要:A novel method has been found to produce 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine as a novel useful intermediate compound. A novel method has been further found to produce thymidine from 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine. A novel method has been further found to L-2′-deoxyribose derivatives as a useful synthetic intermediate through L-2,2′-anhydro-5,6-dihydrocyclouridine derivative. According to these methods, synthesis of various L-nucleic acid derivatives, synthesis of which has been difficult till now.
专利号:US-5288868-A 优先权日:1992-02-13 标题:Process for the preparation of 2-hydroxy-4,6-diaryl-1,3,5-triazine 发明人:REINEHR DIETER; BACHER JEAN-PIERRE 权利人:CIBA GEIGY CORP 摘要:There is disclosed a process for the preparation of 2-hydroxy-4,6-diaryl-1,3,5-triazines by reacting an aromatic nitrile with an alkali metal amide and an alkyl haloformate, using an equimolar amount of each, which process is carried out as a one-pot synthesis. The triazine derivatives obtained by the process of this invention are used as intermediates for the synthesis of UV absorbers.
专利号:US-2013225819-A1 优先权日:2010-08-18 标 题:Use of azides in synthesis 发明人:JAMISON TIMOTHY F; PALDE PRAKASH B 权利人:JAMISON TIMOTHY F; PALDE PRAKASH B; MASSACHUSETTS INST TECHNOLOGY 摘要:Described herein are inventive methods for synthesis of tetrazoles. In some embodiments, the method involves the use of a flow reactor. The methods provided herein are capable at being carried out in short reaction times, with high yields, with minimal side reactions, and/or with minimal chance of explosions caused by the presence of azides.
专利号:US-2002042514-A1 优先权日:2000-06-26 标 题 :Synthesis of chlorinated pyrimidines 发明人:DOYLE TIMOTHY JOHN; WEHRENBERG PETER KARL; STANDEN MICHAEL CHARLES HENRY 摘要:A facile process for the preparation of 4,6-dichloropyrimidine is provided, which utilizes quaternary ammonium salts or quaternary phosphonium salts as catalysts for the reaction of, for example, 4,6-dihydroxypyrimidine or 4-chloro-6-methoxypyrimidine with phosgene.
摘要:Khartulyari, A.; Maier, M. E., Science of Synthesis Knowledge Updates, (2010) 3, 65. 摘要:Glushkov, V. A.; Shklyaev, Yu. V., Science of Synthesis Knowledge Updates, (2018) 3, 232. 摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 383. 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 381. 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 384.