CAS: 58632-95-4; N-((Tert-Butoxycarbonyl)Oxy)Benzimidoyl Cyanide

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CAS号75-44-5 光气 | CAS号75-65-0 叔丁醇 | CAS号69505-71-1 chlor°Carbonylo... | CAS号105090-82-2 (5-氨基-4,4-二甲基戊基... | CAS号45214-91-3 B°C-L-谷氨酸-5-甲酯 | CAS号3262-72-4 B°C-L-丝氨酸 | CAS号56074-20-5 N-B°C-亚氨基二乙酸 | CAS号3303-84-2 B°C-beta-丙氨酸 | CAS号37553-65-4 B°C-N-甲基-L-苯丙氨酸 | CAS号53363-89-6 B°C-N-甲基-L-亮氨酸 | CAS号3392-05-0 叔丁氧羰基-L-丙氨酸 N-丁二酰亚胺酯 | CAS号3978-80-1 N-B°C-L-酪氨酸 | CAS号5068-28-0 N-B°C-S-苄基-L-半胱氨酸

苯乙腈,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于sodium Hydroxide,亚硝酸甲酯体系中,用 甲醇 作为反应溶剂,化学反应生成 2-(叔丁氧羰基氧亚氨基)-2-苯乙腈
参考文献:Peptides. Vi. Some Oxime Carbonates As Novelt-Butoxycarbonylating Reagents
标题:Peptides. Vi. Some Oxime Carbonates As Novelt-Butoxycarbonylating Reagents
摘要:几种肟的叔丁氧羰基衍生物是通过相应的肟基碳酸氯制备的.其中,二乙基(叔丁氧羰氧亚氨基)丙二酸酯和2-(叔丁氧羰氧亚氨基)-2-苯基乙腈被用于在不同条件下制备叔丁氧羰氨基酸.结果总结在一个表格中.
DOI:10.1246/bcsj.50.718

专利信息

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:US-9688644-B2
优先权日:2009-04-30
标 题 :Synthesis of Tetracyclines and intermediates thereto
发明人：MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-2004006137-A1
优先权日:2002-06-28
标题:Asymmetric synthesis of amino-pyrrolidinones and a crystalline, free-base amino-pyrrolidinone
发明人：WALTERMIRE ROBERT E; CAMPAGNA SILVIO; SAVAGE SCOTT A; BORDAWEKAR SHAILENDRA; MADUSKUIE THOMAS P; DESIKAN SRIDHAR; ANDERSON STEPHEN R
摘要:A novel process for the asymmetric synthesis of an amino-pyrrolidinone of the type shown below is described. n n n These compounds are useful as intermediates for MMP and TACE inhibitors. n Crystalline, free-base form of Compound J ((2R)-2-((3R)-3-amino-3-{-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide): n n n which is useful as a TACE inhibitor, pharmaceutical compositions comprising the same, and methods of using the same for treating inflammatory diseases are also described.

专利号:WO-9426779-A1
优先权日:1993-05-13
标 题 :PROCESSES AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS
发明人：MADUSKUIE THOMAS PETER JR
权利人:DU PONT MERCK PHARMA
摘要:This invention provides processes and intermediates for the synthesis of platelet glycoprotein IIb/IIIa inhibitors of formula (I).

专利号:US-5298629-A
优先权日:1992-03-02
标题 :Intermediates in the synthesis of quinoline antibiotics
发明人：BRAISH TAMIN F
权利人:PFIZER
摘要:This invention relates to compounds of the formulae ##STR1## wherein R and X are defined as below. These compounds are useful as intermediates in the syntheses of azabicyclo quinoline carboxylic acids having antibacterial activity.