CAS: 583-78-8; 2,5-Dichlorophenol

上下游产品

2,5 dichloroaniline 2-bromo-1,4-dichlorobenzene 2,5-dichloroiodobenzene sodium methylate 3-(2,5-dichloro-phenoxy)-propionic acid α-(2,5-dichloro-phenoxy)-isobutyric acid 2,5,2',5'-tetrachloro-4,4'-methanediyl-di-phenol 1-(2,4-dichloro-phenoxy)-2-(2,5-dichloro-phenoxy)-ethane

1,4-二氯苯置于水,三乙胺,三氟乙酸体系中,化学反应生成 2,5-二氯苯酚
参考文献:阳极氧化选择性和一锅法形成苯酚
标题:阳极氧化选择性和一锅法形成苯酚
摘要:通过阳极氧化成功地完成了苯和取代苯的直接单羟基化反应,从而以非常好的收率形成了相应的苯酚衍生物.阳极氧化通常在三氟乙酸和含有三乙胺的二氯甲烷的混合溶剂中,使用配备有铂板作为阳极,碳棒作为阴极的分隔式电池进行.具有吸电子基团的苯衍生物适用于本发明的电化学氧化.澄清的是,由自由基阳离子反应形成的初始产物形成了芳基三氟乙酸酯,该自由基阳离子是由一个电子从底物转移到三氟乙酸中,然后在后处理过程中进行水解而得到相应的酚.
DOI:10.1016/s0040-4020(96)00056-7

专利信息

专利号:WO-2024185775-A1
优先权日:2023-03-06
标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same
发明人：OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi
权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY
摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group.　The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.

专利号:WO-2022220019-A1
优先权日:2021-04-16
标题 :Long-chain dna synthesis using non-natural base
发明人：MASAKI YOSHIAKI
权利人:TOKYO INST TECH
摘要:The purpose of the present invention is to provide a method for synthesizing a long-chain nucleic acid (particularly DNA) with high accuracy. The present invention provides a method for synthesizing a long-chain nucleic acid, the method comprising using: (i) a nucleoside-3'-O-phosphoramidite derivative having a non-natural nucleic acid base; or (ii) a nucleoside-3'-O-phosphoramidite derivative having a non-natural nucleic acid base and a nucleoside-3'-O-phosphoramidite derivative having a natural nucleic acid base in the chemical synthesis of a nucleic acid based on the phosphoramidite method.

专利号:WO-2025082632-A1
优先权日:2023-10-16
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU
权利人:BACHEM HOLDING AG
摘要:The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)# to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.

专利号:EP-4605403-A1
优先权日:2022-10-17
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.

专利号:WO-2024061842-A1
优先权日:2022-09-19
标 题:Improved oligonucleotide synthesis
发明人：CREUSEN GUIDO; MINUTH MARCO; SAMSON DANIEL
权利人:BACHEM HOLDING AG
摘要:A method for the solid-phase synthesis of a target oligonucleotide OT is disclosed, wherein said method comprises a step of incubating a nucleoside or oligonucleotide, which is covalently linked to a solid support and comprises a backbone hydroxyl moiety protected by a di(p-methoxyphenyl)phenylmethyl (DMT) protecting group, with a deprotection mixture, thereby cleaving said protecting group from said nucleoside or oligonucleotide, wherein said deprotection mixture is a liquid composition comprising a solvent, a protic acid having a pKa equal to or smaller than 4, and at least one alcohol of Formula (D), wherein in RD-1 R,D-2 R,D-3 RD-4 and RD-5 are indepently of each other selected from the group consisting of H, OH, a e1-e6-alkyl group, O(C1-C6-aIkyl), C(O)(Ci-C6-alkyl), C(O)O(Ci-C6-alkyl), F, Cl, Br, I, and CN. Such a method does not only suppress depurination, but also results in an acceptable product yield.

专利号:WO-2024083746-A1
优先权日:2022-10-17
标 题 :Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.