CAS: 555-45-3; Propane-1,2,3-Triyl Tritetradecanoate

该化合物是源自甲状腺酸的三重晶体.它是在室内温度下的一种白色晶体固体,熔点约为56-57°C.TriMyristin因其稳定,非极性及生物兼容性,在制药,化妆和食品工业中广泛使用.它作为药物配方的先驱,控制释放系统的脂质矩阵,以及皮肤护理产品的溶液.它的高度纯度和可预测的融化行为使它适合差异扫描卡路里测量(DSC)的校准标准. 此外,TriMyMyristin还被用作作为研究三重甲状腺代谢和晶体动力学的模型化合物.

结构式图片

上下游产品

1,2,3-trichloropropane potassium myristate n-tetradecanoic acid glyceroln-tetradecanoic acid glycerol 1,3-dimyristate methyl myristoate 3-(4-hydroxy-3-methoxyphenyl)acrylic acid

合成工艺路线路线简述

    肉豆蔻酸,甘油置于硫酸体系中,用 氯仿 作为反应溶剂,化学反应 3.5H,以54%的收率获得产物甘油三肉豆蔻酸酯
    参考文献:Monomyristin 和 Monopalmitin 衍生物:作为潜在的抗菌和抗真菌剂的合成和评价
    标题:Monomyristin 和 Monopalmitin 衍生物:作为潜在的抗菌和抗真菌剂的合成和评价
    摘要:在目前的工作中,以市售的肉豆蔻酸和棕榈酸为原料,成功地制备了单酰基甘油衍生物,即 1-单肉豆蔻素,2-单肉豆蔻素和 2-单棕榈酸.1-单肉豆蔻碱化合物是通过肉豆蔻酸乙酯和1,2-O-异亚丙基甘油之间的酯交换反应制备的,该反应是用丙酮保护甘油得到的,然后使用amberlyst-15脱保护.另一方面,2-单酰基甘油衍生物是在疏毛嗜热丝孢菌脂肪酶存在下通过甘油三酯的酶水解制备的.使用傅里叶变换红外 (Ftir) 分光光度计,气相或液相色谱-质谱仪 (Gc-Ms 或 Lc-Ms) 分析合成产物,以及质子和碳核磁共振(1H-和 13C-NMR)光谱仪.发现单肉豆蔻酸具有很高的抗菌和抗真菌活性,而 2-单棕榈酸则完全没有任何活性.与阳性对照相比,1-单肉豆蔻素化合物对金黄色葡萄球菌和聚集放线菌显示出更高的抗菌活性,并且对白色念珠菌具有更高的抗真菌活性.同时,2-Monoryristin 对大肠杆菌表现
    DOI:10.3390/molecules23123141

    海关参考信息

    专利信息


    专利号:US-10189951-B2
    优先权日:2014-04-25
    标题 :Aliphatic polyimides from a 1:2 molar ration of diamine and unsaturated monoanhydride or unsaturated diacid
    发明人:DUAN YANNAN; AVAKIAN ROGER W
    权利人:POLYONE CORP
    摘要:Aliphatic polyimides are synthesized by a 2:1 molar ratio reaction of an unsaturated monoanhydride or an unsaturated diacid with a diamine. Bio-derived monomers are particularly useful in the synthesis of the aliphatic polyimides.

    专利号:US-2017044320-A1
    优先权日:2014-04-25
    标题 :Aliphatic polyimides from a 1:1 molar ratio of diamine and unsaturated monoanhydride or unsaturated diacid
    发明人:DUAN YANNAN; AVAKIAN ROGER W
    权利人:POLYONE CORP
    摘要:Aliphatic polyimides are synthesized by a 1:1 molar ratio reaction of an unsaturated monoanhydride or an unsaturated diacid with a diamine. Bio-derived monomers are particularly useful in the synthesis of the aliphatic polyimides.

    专利号:US-9314021-B2
    优先权日:2004-11-03
    标题 :Formulations containing insect repellent compounds
    发明人:SCIALDONE MARK A
    权利人:DU PONT
    摘要:Dihydronepetalactone, a minor natural constituent of the essential oil of catmints ( Nepeta spp.) such as Nepeta cataria , has been identified as an effective insect repellent compound. Synthesis of dihydronepetalactone may be achieved by hydrogenation of nepetalactone, the major constituent of catmint essential oils. This compound, and compositions thereof, which also has fragrance properties, may be used commercially for its insect repellent properties.

    专利号:US-12036300-B2
    优先权日:2021-03-31
    标题:Methods and compositions for improving skin
    发明人:LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
    权利人:OREAL
    摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

    专利号:JP-2009298785-A
    优先权日:1997-02-10
    标 题:Synthesis of acyclic nucleoside derivatives.

    专利号:US-10619008-B2
    优先权日:2014-04-25
    标 题:Aliphatic polyimides from unsaturated monoanhydride or unsaturated diacid reacted with both monoamine and diamine
    发明人:DUAN YANNAN; AVAKIAN ROGER W
    权利人:POLYONE CORP
    摘要:Aliphatic polyimides are synthesized by a reaction of 2 moles of an unsaturated monoanhydride or an unsaturated diacid with both one mole of a diamine and one mole of a monoamine. Imidization of intermediates so formed from those reactions resolve to 6 possible bicyclic imidic structures bridged by monoamidic or saturated hydrocarbon spans, more likely the latter. Bio-derived monomers are particularly useful in the synthesis of the aliphatic polyimides.
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    主要参考文献


    1: Göke K, Roese E, Arnold A, Kuntsche J, Bunjes H. Control over Particle Size Distribution by Autoclaving Poloxamer-Stabilized Trimyristin Nanodispersions. Mol Pharm. 2016 Sep 6;13(9):3187-95. doi: 10.1021/acs.molpharmaceut.6b00395. Epub 2016 Aug 9. doi: 10.1021/jp506787v. Epub 2014 Sep 15. doi: 10.3390/molecules17089274. Epub 2007 Jul 6. Epub 2007 Jan 30. Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate. Int J Toxicol. 2001;20 Suppl
    4:61-94. Review. Epub 2001 Jun 1.

    合成参考文献


    摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
    摘要:Final Report 12/2017 Available from CIR
    摘要:International Journal of Toxicology 20(suppl 4):61-94, 2001
    参考文献:10.1007/bf02522980
    摘要:Smith DR, Knabe DA, Cross HR, Smith SB. A diet containing myristoleic plus palmitoleic acids elevates plasma cholesterol in young growing swine. Lipids. 1996 Aug;31(8):849–58. doi: 10.1007/bf02522980.
    参考文献:10.1007/s11745-001-0770-0
    摘要:Hunter JE. Studies on effects of dietary fatty acids as related to their position on triglycerides. Lipids. 2001 Jul;36(7):655–68. doi: 10.1007/s11745-001-0770-0.
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