CAS: 552-57-8; 5-Hydroxy-2-(4-Hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One
该化合物是来自普通植物植物氟化素(lavanomo)的状甘油甘油,该化合物具有素和酸甘油(包括甘蔗和葡萄糖)的甘油结合.Apigenin 7-O-rutynoside,主要存在于各种植物中,特别是水果和蔬菜中,以其潜在的健康利益而著称,包括抗氧化剂,防炎和抗癌特性.极地溶剂中的复合溶性(对易腐素而言很常见)及其稳定性可能受到诸如pH和温度等因素的影响.在生物活动方面,对素7-O-O-rutynoidesideside,其作用在于调节各种生物化学途径,有助于其治疗潜力.它存在于饮食来源中,可能会对健康造成与植物-富性食品化合物相关的抑制效应.
- 英文名称5-Hydroxy-2-(4-Hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One
- 中文名称异野漆树苷
- IUPAC名称5-hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
- 其它别名7-[[6-O-(6-Deoxy-Alpha-L-Mannopyranosyl)-Beta-D-Glucopyranosyl]Oxy]-5-Hydroxy-2-(4-Hydroxyphenyl)-4H-Benzopyran-4-One; Isorhoifolin With Hplc; Apigenin-7-Rutinoside Hplc; Apigenin-7-O-Rutinoside; Apigenin-7-Rutinoside; Isorhoifolin; 5-Hydroxy-2-(4-Hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyloxan-2-Yl]Oxymethyl]Oxan-2-Yl]Oxychromen-4-One; Diosmin Ep Impurity C (Isorhoifolin)
- CAS编号552-57-8
- MFCD编号:MFCD00148889
- EINECS号:209-015-9
- FDA UNII编号:0B66T65281
- 分子式:C27H30O14分子量:578.52
- 产品CID: 2512104
- 产品分类生物化工 → 提取物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: FKIYLTVJPDLUDL-SLNHTJRHSA-N
- FKIYLTVJPDLUDL-OOGOZOHXNA-N
- 计算化学: 氢键受体数14.0氢键供体数8.0可旋转键数6.0
物理性质
- 熔点270-275°C
- 沸点912.7±65.0 °C(预测)
- 闪点304.1 °C
- 密度1.69±0.1 g/cm3(预测)
- pKa:6.13±0.40(预测)
- PSA:228.97
- LogP:-1.0983
- 折射率1.726
- 溶解性DMSO (Slightly), Pyridine (Slightly)
- 外观形态类白色至淡黄色固体
- 储存条件防潮, 冰箱, 置于惰性气氛下
- 产品应用该化合物是一种在M. LONGIFOLIA中发现并具有多种生物活动的异丙烯的氟甲状腺素甘醇和丙烯丙烯,它抑制了金属蛋白酶-1(MMP-1),MMP-3和MMP-13(IC50S = 0.33, 2.45和 0.22 ΜM)的基质质质素,在E. COLI WP2 TRYPTOPHAN 反向突变中,当用于浓度为2微米时,它具有抗诱发性.
合成工艺路线路线简述
专利信息
专利号:FR-3002543-A1
优先权日:2013-02-28
标题:METHOD FOR THE ENZYMATIC SYNTHESIS OF FLAVONOIDS AND APPLICATION TO THE SYNTHESIS OF DIOSMETIN DERIVATIVES
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Yañez O, Osorio MI, Areche C, Vasquez-Espinal A, Bravo J, Sandoval-Aldana A, Pérez-Donoso JM, González-Nilo F, Matos MJ, Osorio E, García-Beltrán O, Tiznado W. Theobroma cacao L. compounds: Theoretical study and molecular modeling as inhibitors of main SARS-CoV-2 protease. Biomed Pharmacother. 2021 May 24;140:111764. doi: 10.1016/j.biopha.2021.111764. Epub ahead of print.
2: Liang J, Pitsillou E, Man AYL, Madzima S, Bresnehan SM, Nakai ME, Hung A, Karagiannis TC. Utilisation of the OliveNet™ Library to investigate phenolic compounds using molecular modelling studies in the context of Alzheimer's disease. Comput Biol Chem. 2020 Jun 4;87:107271. doi: 10.1016/j.compbiolchem.2020.107271. Epub ahead of print. 13(11):e0207466. doi: 10.1371/journal.pone.0207466.
4: Adenubi OT, Ali Abdalla M, Ahmed AS, Njoya EM, McGaw LJ, Eloff JN, Naidoo V. Isolation and characterization of two acaricidal compounds from Calpurnia aurea subsp. aurea (Fabaceae) leaf extract. Exp Appl Acarol. 2018 Jul;75(3):345-354. doi: 10.1007/s10493-018-0269-4. Epub 2018 May 30. 55(5):694-702. doi: 10.1016/j.ejvs.2018.02.009. Epub 2018 Mar 24. 18(3):660. doi: 10.3390/ijms18030660.
合成参考文献
参考文献:10.1515/znc-2001-7-808
摘要:Kasaj D, Krenn L, Prinz S, Hüfner A, Haslinger E, Yu SS, Kopp B. Flavon- and flavonolglycosides from Achillea pannonica Scheele. Z Naturforsch C J Biosci. 2001 Jul;56(7-8):521–5. doi: 10.1515/znc-2001-7-808.
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