CAS: 5331-14-6; (2-Butoxyethyl)Benzene

相似化合物

3558-60-9 103-52-6 56011-02-0

上下游产品

1-iodo-butane 2-phenylethanol 1-bromo-butane iodobenzene

📜丁酸苯乙酯置于三乙基硅烷,Indium(Iii) Bromide体系中,用 氯仿 作为反应溶剂,以47 %的收率获得产物(2-丁氧乙基)苯
参考文献:半稳定 Nhc-金络合物及其在原料烯烃氧化还原中性 1,2-氧芳基化中的应用
标题:半稳定 Nhc-金络合物及其在原料烯烃氧化还原中性 1,2-氧芳基化中的应用
摘要:半不稳定 (C^n) N-杂环卡宾配体介导芳基碘化物与 Au I中心的氧化加成.对氧化加成过程进行了研究和计算分析.该过程实现了"无外源氧化剂"au I /au Iii催化乙烯和丙烯 1,2-氧基芳基化的第一个例子.
DOI:10.1002/anie.202301526

专利信息

专利号:US-2005214310-A1
优先权日:2004-01-23
标 题 :Melphalan prodrugs
发明人：TOKI BRIAN E; SENTER PETER D
权利人:SEATTLE GENETICS INC
摘要:Shown and described are the synthesis of more potent forms of C-Mel, a prodrug used in Antibody-Directed Enzyme Prodrug Therapy, that releases the clinically used anticancer alkylating agent melphalan extracellularly. Shown and described are the synthesis of a variety of melphalan analogues with the intention to promote facile intracellular drug access. Esters, amides, and peptides of melphalan are shown. Cephalosporin prodrugs of the most interesting melphalan derivatives were synthesized and evaluated for potency, toxicity, therapeutic window, plasma stability, and solubility.

专利号:US-2008200475-A1
优先权日:2005-03-28
标题:4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: (I) wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2a , R x , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.