CAS: 52130-17-3; 3-Amino-2-Methylbenzoic Acid

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CAS号1975-50-4 2-甲基-3-硝基苯甲酸 | CAS号1072901-47-3 3-(9H-fluoren-9... | CAS号42981-93-1 3-甲氧基-2-甲基苯甲酸甲酯 | CAS号55-21-0 苯甲酰胺 | CAS号204782-99-0 8-methylquinoli... | CAS号188700-63-2 methyl 2-methyl... | CAS号603-80-5 3-羟基-2-甲基苯甲酸 | CAS号55289-06-0 3-甲氧基-2-甲基苯甲酸 | CAS号133232-56-1 3-碘-2-甲基苯甲酸 | CAS号306276-93-7 5-Benzothiazole... | CAS号33797-34-1 (3-甲氧基-2-甲基苯基)甲醇

2-甲基-3-硝基苯甲酸置于palladium 10% On Activated Carbon,氢气体系中,用 乙酸乙酯 作为反应溶剂,化学反应 48.0H,反应生成 2-甲基-3-氨基苯甲酸
参考文献:Viscoelasticity,Dielectric Anisotropy,And Birefringence In The Nematic Phase Of Three Four-Ring Bent-Core Liquid Crystals With An L-Shaped Molecular Frame
标题:Viscoelasticity,Dielectric Anisotropy,And Birefringence In The Nematic Phase Of Three Four-Ring Bent-Core Liquid Crystals With An L-Shaped Molecular Frame
摘要:分子形状是决定热致液晶(lc)材料性质的重要因素.我们合成并研究了几种由不对称弯曲分子构成的液晶化合物,这些分子具有一个形状像字母"l"的刚性四环核心.我们测量了介电常数,双折射,撓曲 K1 和弯曲 K3 弹性常数,撕裂粘度 ηsplay 以及流动粘度 η|| 和 η⊥ 的温度依赖性.弯曲-撕裂各向异性 δk31 = K3 − K1 为负,类似于由对称弯曲的 V 形分子形成的向列型液晶的情况.介电各向异性 δε 和双折射在整个向列相范围内均为正.撕裂粘度 ηsplay 和流动粘度 η|| 及 η⊥ 小于在类似温度下测得的对称 V 形弯曲核心材料的粘度.比率 γ = ηsplay/η||,⊥置于5-4 范围内,这是典型的杆状液晶的特征.报道的 L 形弯曲核心向列型液晶结合了弯曲核心液晶的有用特征(例如负的 δk31,适合于广范围蓝相的形成)与相对较低的粘度,这是杆状液晶的典型特性,对于电光开关应用具有益处.
DOI:10.1039/c2Sm26448J

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-6258323-B1
优先权日:1998-11-16
标题:Apparatus and method used in multiple, simultaneous synthesis of general compounds
发明人：HORMANN ROBERT EUGENE; GILBERT DARYL EUGENE; SIOMA EDWARD MICHAEL
权利人:ROHM & HAAS
摘要:The apparatus and method of the present invention provides for conducting simultaneous multiple synthesis of general compounds, which often takes place under varied uneven conditions requiring heating, cooling, agitation, reagent/solvent additions to the reactor contents at each reaction vessel location, supply and maintenance of inert atmosphere and means to facilitate the reflux of the reactor contents. Thus, it becomes necessary to monitor and control the reaction conditions during the simultaneous multiple synthesis of general compounds. The apparatus allows the user to connect various independently controlling and conveying means to each reaction vessel through multiple ports provided on a stopper mounted on each reaction vessel. The apparatus of the present invention permits user to readily access the reaction vessels without interrupting the reactions occurring in the adjacent reaction vessels. The unique geometry and shape of the stopper allows positioning of multiple ports, while still providing the stopper with a compact size. As a result, a large array of reaction vessels can be accommodated in the device of the present invention without significantly increasing the overall size of the apparatus. Some of the general compounds that can be readily synthesized by the apparatus and the method of the present invention include inorganic compounds as well as organic compounds, such as oligomers, polymers, agricultural chemicals, drugs, peptides and oligonucleotides.

专利号:US-11447454-B2
优先权日:2015-08-07
标题:Synthesis of benzodiazepine derivatives
发明人：BOYCE MALCOLM JAMES; THOMSEN LIV; GILBERT DONALD ALAN; WOOD DAVID
权利人:TRIO MEDICINES LTD
摘要:The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I:

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-9710221-A1
优先权日:1995-09-15
标 题:Synthesis of quinazolinone libraries
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TORREY PINES INST
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-2024133619-A1
优先权日:2022-12-23
标 题 :New process for the manufacture of mdm2-p53 antagonists
发明人：SHAO JIDONG; XIAO QING; Zhang Dihan; ZHU ZHIBIN
权利人:BOEHRINGER INGELHEIM INT
摘要:This invention relates to a novel process for the synthesis of substituted aniline of formula (1) or salts thereof via hydroxy-indolinone of formula (13). The process of this invention is palladium free and uses oxygen as green and save oxidant for the copper promoted ring- opening of a hydroxy-indolinone bicycle to a tetra substituted aniline.