CAS: 46464-11-3; 1-[(4-Methoxyphenyl)Methyl]-2,3-Dimethylguanidine

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    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:US-6080860-A
    优先权日:1992-08-31
    标 题:Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
    发明人:KARIMIAN KHASHAYAR; MURTHY KESHAVA; HALL DARREN
    权利人:BRANTFORD CHEMICALSS INC
    摘要:Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.

    专利号:US-10814013-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A1
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:US-2008107598-A1
    优先权日:2006-10-05
    标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

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    主要参考文献


    1: Warren JT, Coker GG, Welch RM, Fowle AS, Findlay JW. Plasma levels of a novel antidysrhythmic agent, meobentine sulfate, in humans as determined by radioimmunoassay. J Pharm Sci. 1982 Jun;71(6):665-70.
    3: Anderson JL, Reid PR, Platia EV, Akhtar M, Ruskin JN, Schaal SF, Jueng P, Long RA, Wenger TL. Meobentine sulfate: antiarrhythmic and electrophysiologic effects assessed by programmed electrical stimulation and ambulatory monitoring in patients with complex ventricular tachyarrhythmia. Report of a multicenter evaluation. Am Heart J. 1985 Oct;110(4):774-84.

    合成参考文献


    参考文献:10.1097/00005344-198611000-00014
    摘要:Dangman KH, Wang HH, Reynolds RD. Studies on bethanidine and meobentine: direct and indirect effects of antifibrillatory drugs. J Cardiovasc Pharmacol. 1986 Nov;8(6):1185–94. doi: 10.1097/00005344-198611000-00014.
    参考文献:10.1007/978-3-642-85624-2_12
    摘要:Black SC, Friedrichs GS, Lucchesi BR. Experimental Models for the Assessment of Antiarrhythmic and Proarrhythmic Drug Action: Traditional and Newer Models. 1995. In: Antiarrhythmic Drugs.
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