CAS: 441785-25-7; ((1-((2-Amino-9H-Purin-9-yl)Methyl)Cyclopropoxy)Methyl)Phosphonic Acid

上下游产品

Diisopropyl ({1-[(2-Amino-9H-Purin-9-yl)Methyl]Cyclopropyl}Oxy)Methylphosphonate 693788-86-2
Diisopropyl ({1-[(2-Amino-6-Chloro-9H-Purin-9-yl)Methyl]Cyclopropyl}Oxy)Methylphosphonate 441784-88-9

📜Diethyl [(1-{[(2,5-Diaminopyrimidin-4-yl)Amino]Methyl}Cyclopropoxy)Methyl]Phosphonate置于盐酸,三甲基溴硅烷体系中,用 二氯甲烷,水 作为反应溶剂,化学反应生成 P-[[[1-[(2-氨基-9H-嘌呤-9-基)甲基]环丙基]氧基]甲基]-磷酸
参考文献:Lb80380药物的中间体化合物及其制备方法 和用途
标题:Lb80380药物的中间体化合物及其制备方法 和用途
摘要:本发明提供了一种lb80380中间体化合物(如式i所示),其中,R1,R2,R3,R4各自独立地选自直链或支链烷基,被1个或5个r5取代的苄基,或r5Co,所述r1,R2,R3,R4相同或不同;r5选自氢,取代或未取代的c1‑c4烷氧基,C3‑c7烯基烷氧基或取代或未取代的苄氧基.本发明还提供了式ⅰ化合物的制备方法及其用途.式ⅰ化合物用于制备化合物3‑[({1‑[(2‑氨基‑9H‑嘌呤‑9‑基)甲基]环丙基}氧基)甲基]‑8,8‑二甲基‑3,7‑二氧代‑2,4,6‑三氧杂‑3λ5‑磷杂壬‑1‑基‑新戊酸酯时,反应路线原料,中间物料廉价易得,成本低,安全性好,适合工业化生产.

专利信息

专利号:CN-107602559-B
优先权日:2017-09-29
标题:A method of the asymmetric ciprofloxacin eye drops synthesis of chiral ternary carbocyclic nucleoside caused by Michael's addition

专利号:CN-111646948-A
优先权日:2020-07-03
标 题 :Method for Synthesis of Chiral Pyrimidine Substituted Diesteryl Cyclopropane by Asymmetric Cyclopropanation

专利号:CN-107602559-A
优先权日:2017-09-29
标 题 :A method for the synthesis of chiral three-membered carbocyclic nucleosides by asymmetric cyclopropanation initiated by Michael addition

专利号:CN-111646948-B
优先权日:2020-07-03
标 题:Method for Synthesis of Chiral Pyrimidine Substituted Diesteryl Cyclopropane by Asymmetric Cyclopropanation

专利号:JP-3959348-B2
优先权日:2001-01-19
标题:Novel acyclic nucleoside phosphonate derivatives, their salts and methods of synthesis

专利号:JP-2004518675-A
优先权日:2001-01-19
标题 :Novel acyclic nucleoside phosphonate derivative, salt thereof and method of synthesis