CAS: 4228-66-4; 3-(3,4-Dihydroxyphenyl)-2-Oxopropanoic Acid

上下游产品

α-acetylamino-β-(3,4-diacetoxyphenyl)acrylic acid 3,4-dihydroxybenzaldehyde 2-methyl-4-(3,4-diacetoxybenzylidene)oxazolone 4-hydroxyphenylpiruvic acid 3-(3,4-dihydroxybenzyl)-3,4,5,6-tetrahydr°Carboline hydr°Chloride 1-carboxy-6,7-dihydroxy-1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydr°Chloride 6,7-dihydroxy-1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid danshensu

📜左旋多巴置于l-Amino Acid Deaminase体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应 6.0H,反应生成 3,4-二羟基苯基丙酮酸
参考文献:嗜热酪氨酸苯酚酶和l-乳酸氧化酶的偶合合成l-酪氨酸衍生物
标题:嗜热酪氨酸苯酚酶和l-乳酸氧化酶的偶合合成l-酪氨酸衍生物
摘要:一锅生物级联反应由l-乳酸氧化酶(avlox)和设计的嗜热酪氨酸-苯酚裂解酶(ttpl)突变体催化的两个酶促步骤用于合成l-酪氨酸衍生物,其中丙酮酸是由avlox从现成的生物基升-乳.
DOI:10.1002/ejoc.202000061

专利信息

专利号:US-4962223-A
优先权日:1988-07-12
标题:Process for the synthesis of the levodopa
发明人：CANNATA VINCENZO; TAMERLANI GIANCARLO; MOROTTI MAURO
权利人:MINI RICERCA SCIENT TECNOLOG
摘要:New process for the synthesis of the levodopa, L-(-)-2-amino-3-(3,4-dihydyphenyl)propionic acid, drug used in the treatment of the Parkinson's disease. The process consists in resolving with d-camphorsulfonic acid, or with a salt thereof, the d,l-2-amino-3-(3,4-dimethoxyphenyl)propionitrile, obtained from the 3,4-dimethoxyphenylacetaldehyde, and in the subsequent hydrolysis and demethylation, by means of concentrated solutions of haloid acids, of the d-2-amino-3-(3,4-dimethoxyphenyl)propionitrile and of salts thereof.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-2024084338-A1
优先权日:2022-11-22
标 题 :Recombinant Escherichia coli for producing rosmarinic acid and its application thereof
发明人：ZHOU JINGWEN; CHEN JIAN; WANG LIAN; ZENG WEIZHU; YU SHIQIN
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses a recombinant Escherichia coli for producing rosmarinic acid and application thereof, belonging to the technical fields of genetic engineering and bioengineering. In the present disclosure, FjTA derived from Flavobacterium johnsoniae, endogenous hpaBC derived from E. coli, CbRAS derived from Coleus blumei, HPPR derived from Coleus scutellarioides, and Pc4CL1 derived from Petroselinum crispum are heterologously expressed in E. coli, realizing synthesis of rosmarinic acid. TcTAL derived from Trichosporon cutaneum and tyrC for removing feedback inhibition are introduced, further increasing synthesis throughput of caffeic acid, and PmLAAD derived from Proteus myxofaciens is heterologously expressed, realizing redistribution of L-DOPA. An endogenous gene menl is knocked out, improving the content and stability of a rosmarinic acid precursor. The recombinant strain constructed in the present disclosure can produce rosmarinic acid by fermentation at a yield of up to 511.2 mg/L, providing a new method for industrial production of rosmarinic acid.

专利号:US-8017786-B2
优先权日:2006-05-15
标 题:Substituted β-phenyl-α-hydroxy-propanoic acid, synthesis method and use thereof
发明人：ZHENG XIAOHUI; ZHANG QUNZHENG; WANG SHIXIANG; ZHAO XINFENG
权利人:UNIV NORTHWEST
摘要:The present invention relates to a compound of the formula (I), wherein R 1 , R 2 and R 3 are each independently selected from H, OH, F, Cl, Br, methoxy and ethoxy; or alternatively, R 1 and R 2 together form —OCH 2 O—, R 3 is selected from H, OH, methoxy, ethoxy and halogens; R 4 is OH or acyloxy; R 5 is cycloalkoxyl, amino and substituted amino, and when R 5 is selected from amino, at least one of R 1 , R 2 and R 3 is not H. The present invention further relates to a process for synthesizing a compound of the formula (I), and use of the compound of the formula (I) in the manufacture of a medicament for the prevention or treatment of cardiovascular or cerebrovascular diseases.

专利号:EP-4206236-A1
优先权日:2021-12-28
标题 :Compounds, their synthesis and compositions comprising the compounds for enhanced deposition of polymers onto hair surfaces
发明人：BREAKSPEAR STEVEN; NÖCKER BERND; WEITZEL JOHANNA; PAEZ JULIETA; PEARSON SAMUEL; BRÃœCK STEFAN; CAMPO ARANZAZU DEL
权利人:KAO CORP
摘要:The present invention is on polymers derivatized with an organic deposition-enhancing group for their enhanced deposition onto keratin fibers, especially human hair. The deposition-enhancing group is a di-hydroxyl phenolic compound with a spacer alkyl group bound to a reactive amine or carboxyl group, which reacts with one of the hydroxyl, carboxyl, primary and secondary amine groups on the polymeric backbone. The invention is on the method of synthesizing such compounds and compositions comprising the compounds.

专利号:CN-203530178-U
优先权日:2013-08-29
标题 :Recovery device of excessive hydroquinone during synthesis of DHPPA (R-(+)-2-(4-hydroxyphenoxy) propionic acid