CAS: 39263-32-6; 2-Amino-5-Bromobenzonitrile

上下游产品

CAS号1885-29-6 2-氨基苯甲腈 | CAS号75-16-1 甲基溴化镁 | CAS号52727-57-8 5-溴代邻氨基苯甲酸甲酯 | CAS号878133-05-2 N-(4-bromo-2-io... | CAS号66416-72-6 4 -溴- 2-碘苯甲胺 | CAS号106-40-1 对溴苯胺 | CAS号5794-88-7 2-氨基-5-溴苯甲酸 | CAS号32084-59-6 6-溴喹喔啉-4-醇 | CAS号88145-89-5 6-溴喹唑啉-2,4-二酮 | CAS号19619-22-8 4-氨基间苯二腈 | CAS号220269-80-7 ethyl N-(4-brom... | CAS号21419-48-7 6-溴喹唑啉-4-胺 | CAS号61272-71-7 3-氨基-5-溴-1H-吲唑 | CAS号133208-93-2 Ibrolipim | CAS号102393-82-8 6-溴-2,4-二氯喹唑啉 | CAS号121554-10-7 5-溴-2-碘苯甲腈 | CAS号33443-53-7 6-BROMO-4-PHENY...

2-氨基苯甲腈置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙腈 用作溶剂,以97%的收率获得2-氨基-5-溴苯甲腈
参考文献:Synthesis Of Arylbromides From Arenes And N-Bromosuccinimide (Nbs) In Acetonitrile-A Convenient Method For Aromatic Bromination
标题:Synthesis Of Arylbromides From Arenes And N-Bromosuccinimide (Nbs) In Acetonitrile-A Convenient Method For Aromatic Bromination
摘要:利用乙腈中的 N-溴代丁二酰亚胺(nbs),可以很容易地对一系列活化的炔类化合物进行区域选择性和化学选择性亲电溴化反应.与其他亲电溴化条件相比,该方法的环境友好,底物范围大且易于合成,从而提高了其实用性.
Doi:10.1139/v08-176

专利信息

专利号:US-9205087-B1
优先权日:2014-02-19
标题:6-Piperazinyl-3,4-dihydroquinazolin-2(1H)-ones
发明人：ULLAH NISAR
权利人:UNIV KING FAHD PET & MINERALS; KING ABDULAZIZ CITY SCI & TECH
摘要:A series of new 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones have been synthesized. The compounds are structurally related to adoprazine, a potential atypical antipsychotics bearing potent D 2 receptor antagonist and 5-HT 1A receptor agonist properties. Buchwald-Hartwig coupling of suitably modified aryl bromides with tert-butyl piperazine-1-carboxylate afforded the advanced intermediate piperazinyl-3,4-dihydroquinazolin-2(1H)-one. The reductive amination of the latter with appropriately designed biarylaldehydes accomplished the synthesis of these compounds.

专利号:RU-2197482-C2
优先权日:1997-04-22
标 题 :Substituted phenyl derivatives, method of their synthesis, pharmaceutical composition comprising thereof and method of treatment (variants)