CAS: 36070-80-1; 5-Chloropyrazine-2-Carboxylic Acid

相似化合物

33332-25-1 36070-75-4 72788-94-4

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2-chloro-5-furan-2-yl-pyrazine 2-Hydroxy-5-(2'-furyl)pyrazine methyl 5-chloropyrazine-2-carboxylate hexan-1-ol methyl 5-chloropyrazine-2-carboxylate methyl 5-methoxypyrazine-2-carboxylate 5-hydroxypyrazinoic acid 5-chloropyrazine-2-carboxylic acid tert-butyl ester

5-羟基吡嗪-2-羧酸置于氯化亚砜,水,N,N-二甲基甲酰胺体系中,化学反应 4.0H,反应生成 5-氯吡嗪-2-羧酸
参考文献:与新型水杨酰苯胺酯和氨基甲酸酯抗药性强的新兴病原体脓肿分枝杆菌和结核分枝杆菌
标题:与新型水杨酰苯胺酯和氨基甲酸酯抗药性强的新兴病原体脓肿分枝杆菌和结核分枝杆菌
摘要:在分枝杆菌属中,已经描述了一百多个物种,并且定期报告了新的物种.在一周内形成菌落的物种被归类为快速生长者,需要较长时间(长达三个月)的物种是大多数致病性缓慢的生长者.最近,已经发现了新出现的物种以延长名单,所有这些都是快速种植者.其中,脓肿分枝杆菌也是一种细胞内病原体,它是对化疗耐药性最强的快速增长的分枝杆菌.此外,耐多药结核分枝杆菌的病例感染也在增加.因此,迫切需要找到对抗这些威胁菌株的新的活性分子.基于先前的结果,设计,合成和表征了一系列的水杨酰苯胺,水杨酰苯胺5-氯吡嗪酸酯和氨基甲酸酯.评估了这些化合物对脓肿分支杆菌,易感结核分支杆菌h 37 Rv,多药耐药性(mdr)结核分支杆菌mdr A8,结核分支杆菌的体外活性mdr 9449/2006和具有极强抗性的praha 131(xdr)菌株.所有衍生物均表现出显着的活性,并且在低微摩尔范围内具有最低抑菌浓度(mic).八种水杨酰苯胺氨
DOI:10.1016/j.Ejmech.2015.07.001

专利信息

专利号:US-10253004-B2
优先权日:2017-01-26
标 题:Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
发明人：ECKHARDT MATTHIAS; WAGNER HOLGER; PETERS STEFAN
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of formula I, n nwherein the groups R, R 1 , R 2 , R 3 , m and n are defined herein, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:JP-2018058822-A
优先权日:2016-08-03
标题 :Heteroaryl sulfone based conjugation handles, methods for their preparation, and their use in the synthesis of antibody drug conjugates

专利号:JP-7555998-B2
优先权日:2016-08-03
标 题 :Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in the synthesis of antibody drug conjugates - Patents.com

专利号:US-9744173-B2
优先权日:2014-04-10
标题 :2-amino 6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
发明人：BRODNEY MICHAEL AARON; BECK ELIZABETH MARY; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; BARREIRO GABRIELA; LACHAPELLE ERIK ALPHIE; ROGERS BRUCE NELSEN
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variable R 1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-107840828-B
优先权日:2017-12-14
标题:Synthesis method of 2-chloro-5-trifluoromethylpyrazine

专利号:CN-113880847-A
优先权日:2021-11-09
标 题 :A kind of cyclotryptamine alkaloid, its synthesis method and application