专利号:US-2024294532-A1 优先权日:2021-07-12 标题 :Synthesis of chiral substituted pyrazolopyrimidine compounds 发明人:TOMAS LOÃ?C; HARRIS CRAIG STEVEN 权利人:GALDERMA HOLDING S A 摘要:The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of mechanistic target of rapamycin (mTOR).
专利号:US-5663397-A 优先权日:1995-09-14 标 题 :Cyclic silyl enol ethers and method of preparing the same 发明人:YAMASHITA HIROSHI; TANAKA MASATO 权利人:AGENCY IND SCIENCE TECHN 摘要:There is disclosed a method of preparing cyclic silyl enol ethers (1-oxa-2-sila-5-cyclohexenes), comprising reacting a silacyclobutane with an acid halide in the presence of a palladium catalyst and an organic base. There is also disclosed novel cyclic silyl enol ethers obtained by the above method. The above cyclic silyl enol ethers belong to a new class of silyl enol ethers which are useful in the production of medicines and agricultural chemicals, and they can be used as intermediates of fine chemicals or as various reagents for fine synthesis.
专利号:EP-4370517-A1 优先权日:2021-07-12 标题 :Synthesis of chiral substituted pyrazolopyrimidine compounds
专利号:CN-110204558-B 优先权日:2014-08-15 标 题:Synthesis of cephalosporin compounds
专利号:WO-2023285926-A1 优先权日:2021-07-12 标题 :Synthesis of chiral substituted pyrazolopyrimidine compounds
专利号:US-11459325-B2 优先权日:2018-01-31 标题:Heterocyclic compound 发明人:TANAKA YUTA; OHASHI TOMOHIRO; IKEDA ZENICHI; TANAKA YUTA; PÜNNER FLORIAN; YAMAMOTO TAKESHI; KAKEGAWA KEIKO; KIKUCHI FUMIAKI; MORISHITA NAO; KASAHARA TAKAHITO; SETO MASAKI; NAKAMURA MINORU; TAKAMI KAZUAKI; MURAKAMI MASATAKA; DAINI MASAKI; MIKAMI SATOSHI; SASAKI MINORU 权利人:TAKEDA PHARMACEUTICALS CO 摘要:The present invention provides a compound having a glucosylceramide lowering action (e.g., promoting glucosylceramide metabolism, inhibition of glucosylceramide synthesis, promoting glucosylceramide catabolism, etc.), which is expected to be useful as an agent for the prophylaxis or treatment of lysosome diseases (e.g., Gaucher's disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like. n The present invention relates to a compound represented by the formula (I): n nwherein each symbol is as described in the specification, or a salt thereof.