CAS: 244-76-8; 9H-Pyrido[2,3-B]Indole

该化合物是一种环环生物化合物,具有由和杂物组成的双环结构,具有发酵性,具有芳香性质,有助于其稳定性和潜在反应力,通常呈现一种固态的黄色至褐色的灰色,在有机溶剂中可以溶解.其结构中氮原子的存在具有基本特性,使其得以参与各种化学反应,包括电益替代.9H-Pyrido[2,3-b] Indole由于潜在的生物活动,包括抗试管和抗微生物特性,对医药化学产生了兴趣.它的独特结构使得它与生物目标相互作用,使其成为药物开发研究的课题.此外,它可以作为合成更复杂的有机化合物的建筑块块.与许多热循环一样,其特性可能受到亚化学和周围化学环境的影响,使它成为有机合成和药物应用的多元化合物.

结构式图片

欧盟法规

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上下游产品

CAS号4253-80-9 3-(2‐nitropheny... | CAS号54904-02-8 3-bromo-N-pheny... | CAS号6604-94-0 3-chloro-N-phen... | CAS号2402-77-9 2,3-二氯吡啶 | CAS号2622-14-2 三环己基膦 | CAS号13534-89-9 2,3-二溴吡啶 | CAS号13174-93-1 1-(2-吡啶)苯并噻唑 | CAS号122-31-6 1,1,3,3-四乙氧基丙烷 | CAS号36982-86-2 2-tosylamidoindole | CAS号25208-32-6 4-氯α-咔啉

合成工艺路线路线简述

  • 1130816-42-0 = 244-76-8 + 87109-10-2
    反应条件:1.1 Reagents: Zinc Catalysts: Iron Tetraphenylporphyrin Chloride Solvents: Benzene; 4 H,120 °C1.2 20 H,120 °C
    标题:An Iron(Ii)-Based Metalloradical System For Intramolecular Amination Of C(Sp2)-H And C(Sp3)-H Bonds: Synthetic Applications And Mechanistic Studies
    作者:Das,Sandip Kumar; Et Al
    参考文献:Chemical Science 日期:2022 卷标:13(40) 页码:11817-11828]

    98-80-6 + 54230-88-5 = 244-76-8 + 87109-10-2
    反应条件:1.1 Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: 1,2-Dimethoxyethane; 6 H,80 °C2.1 Reagents: Zinc Catalysts: Iron Tetraphenylporphyrin Chloride Solvents: Benzene; 4 H,120 °C2.2 20 H,120 °C
    标题:An Iron(Ii)-Based Metalloradical System For Intramolecular Amination Of C(Sp2)-H And C(Sp3)-H Bonds: Synthetic Applications And Mechanistic Studies
    作者:Das,Sandip Kumar; Et Al
    参考文献:Chemical Science 日期:2022 卷标:13(40) 页码:11817-11828]

    52200-48-3 = 244-76-8 + 87109-10-2
    反应条件:1.1 Reagents: Hydrochloric Acid,Sodium Azide Solvents: Ethanol,Water; 24 H,120 °C2.1 Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: 1,2-Dimethoxyethane; 6 H,80 °C3.1 Reagents: Zinc Catalysts: Iron Tetraphenylporphyrin Chloride Solvents: Benzene; 4 H,120 °C3.2 20 H,120 °C
    标题:An Iron(Ii)-Based Metalloradical System For Intramolecular Amination Of C(Sp2)-H And C(Sp3)-H Bonds: Synthetic Applications And Mechanistic Studies
    作者:Das,Sandip Kumar; Et Al
    参考文献:Chemical Science 日期:2022 卷标:13(40) 页码:11817-11828
2,3-二氯吡啶置于palladium Diacetate,1,8-二氮杂双环[5.4.0]十一碳-7-烯,三苯基膦,Tricyclohexylphosphine Tetrafluoroborate,Sodium T-Butanolate体系中,用 N,N-二甲基乙酰胺,邻二甲苯 用作溶剂,化学反应 48.0H,反应生成9H-吡啶并[2,3-B]吲哚
参考文献:Organic Electroluminescent Materials Containing Carboline Group And Organic Electroluminescent Device By Using The Same
标题:Organic Electroluminescent Materials Containing Carboline Group And Organic Electroluminescent Device By Using The Same
摘要:通用公式(1)中显示了一种有机电致发光材料,其中r3是一个咔啉基团,R13是一个咔唑基团或一个咔啉基团,R1至r2,R4至r12和r14至r20分别独立地选择自氢原子,氟原子,氰基,烷基,环烷基,烷氧基,卤代烷基,硫代烷基,硅基和烯基的群.

海关参考信息

专利信息


专利号:US-7160517-B2
优先权日:2000-08-18
标题 :Apparatus and methods for the automated synthesis of oligosaccharides
发明人:SEEBERGER PETER H; PLANTE OBADIAH J
权利人:MASSACHUSETTS INST OF TECHNOLG
摘要:One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the present invention is used in combinatorial methods, e.g., as described herein, of synthesizing oligosaccharides.

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人:MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-10711138-B2
优先权日:2016-04-08
标题:Intermediates and procedures for the synthesis of functional materials
发明人:KIRSCH PEER; GUNST SUSANN
权利人:MERCK PATENT GMBH
摘要:The present invention relates to heteroaromatic compounds which have two different reactive groups, their use in the synthesis of asymmetrically substituted compounds, and synthesis processes in which the compounds according to the invention are reacted sequentially with two different compounds, whereby an asymmetrically substituted compound is formed.

专利号:US-7692019-B2
优先权日:2000-12-04
标 题:Methods for the stereoselective synthesis of substituted piperidines
发明人:AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HEFFERNAN MICHELE L R; HOEMANN MICHAEL Z; KESSLER DONALD W; SHAO LIMING; WU XINHE; XIE ROGER L
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in the synthesis of compounds useful for treatment of numerous ailments, conditions and diseases that afflict mammals, including but not limited to addiction and pain. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the substituted piperidines using the methods of the present invention. An additional aspect of the present invention relates to enantiomerically substituted pyrrolidines, piperidines, and azepines.

专利号:US-8877930-B2
优先权日:2009-11-04
标 题 :Continuous flow synthesis of amino alcohols using microreactors
发明人:BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F
权利人:BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F; MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.

专利号:US-6579725-B1
优先权日:1999-03-05
标题 :Linkers for synthesis of oligosaccharides on solid supports
发明人:SEEBERGER PETER H; ANDRADE RODRIGO B
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention relates to versatile linkers for tethering a molecule to a solid support, e.g., for tethering a monomer, oligomer or polymer to a solid support, which are stable to a wide range of reaction conditions, but can be cleaved under well-defined conditions, thereby liberating the molecule from the solid support. Preferably, the linkers are used to tether to the solid support unprotected, partially-protected or fully-protected monosaccharides or oligosaccharides, or unprotected, partially-protected or fully-protected glycoconjugates. The linkers of the present invention may be used to tether to solid supports building blocks useful in the assembly of libraries of other types of small molecules. The present invention also relates to a molecule or plurality of molecules tethered to the solid support via a linker or linkers of the present invention. The present invention also relates to processes for synthesizing molecules, e.g., monomers, oligomers or polymers, on a solid support, wherein a starting material in the synthesis of the molecule, intermediates in the synthesis of the molecule, and the molecule itself are tethered to the solid support during the process via one of the linkers of the present invention. In certain processes of the present invention, the molecule is liberated from the solid support by cleavage of the linker of the present invention.
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合成参考文献


摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 87.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 78.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 21.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 23.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 60.
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