CAS: 20443-98-5; 2,6-Dichlorobenzyl Bromide

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CAS号118-69-4 2,6-二氯甲苯 | CAS号15258-73-8 2,6-二氯苄醇 | CAS号61875-53-4 (2,6-二氯苯基)乙酰氯 | CAS号111500-01-7 [1-(2,6-dichlor... | CAS号7732-18-5 水 | CAS号10035-10-6 氢溴酸 | CAS号328062-72-2 3-((2,6-二氯苄基)氧基)苯甲醛 | CAS号33486-90-7 2,6-二氯苯甲基甲醚 | CAS号55775-97-8 2 6-二氯-3-硝基苯甲酸 | CAS号50-30-6 2,6-二氯苯甲酸 | CAS号103-50-4 二苄醚 | CAS号303997-00-4 1-(2,6-DICHLORO... | CAS号83-38-5 2,6-二氯苯甲醛 | CAS号6575-27-5 2,6-二氯苄胺 | CAS号128833-96-5 2-AMINO-3-(2,6-... | CAS号166049-76-9 4-[(2,6-二氯苄基)氧基]苯甲醛

反应生成2,6-二氯苄基溴
参考文献:Free Radical Reactions Initiated By Organocobalt Complexes. A New Method For The Degradation Of Carboxylic Acids Tofunctionalised Nor-Alkanes Via Acylcobalt Salophen Intermediates.
标题:Free Radical Reactions Initiated By Organocobalt Complexes. A New Method For The Degradation Of Carboxylic Acids Tofunctionalised Nor-Alkanes Via Acylcobalt Salophen Intermediates.
摘要:
Doi:10.1016/s0040-4039(00)80190-2

专利信息

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:EP-0641333-B1
优先权日:1992-05-20
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

专利号:EP-0855388-B1
优先权日:1993-11-23
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.

专利号:US-2002161234-A1
优先权日:1990-11-19
标 题 :Method of preparing intermediates useful in synthesis of retroviral protease inhibitors

专利号:US-5872299-A
优先权日:1990-11-19
标 题 :Method of preparing intermediates for retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide or cyanohydrin from a chiral alpha amino aldehyde.