CAS: 192927-63-2; 1-Cyclopropyl-6-Fluoro-7-((4As,7As)-Hexahydro-1H-Pyrrolo[3,4-B]Pyridin-6(2H)-yl)-8-Methoxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrochloride Hydrate

该化合物是一个复杂的有机化合物,其独特的双环结构包括quinoline和pyrrollidine mometys.该化合物具有环球体和氟丙醇原子组的特点,能够影响其生物活动和药源特性.甲氧基化合物的存在表明,极溶液结合和溶液溶液具有潜力.作为盐盐,有可能在水环境中表现出更稳定,更溶解性,适合药物应用.水合物形式表明水分子在其晶结构中的存在,它能够影响其物理特性,特别是化学剂在熔化中具有总体化学作用.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

1-cyclopropyl-7-[(S,S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid fumarate moxifloxacin tartaric acid 1-cyclopropyl-7-[(S,S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid di-p-toluoyl-L-tartarate 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acidmoxifloxacin hydr°Chloride

合成工艺路线路线简述

    📜1-Cyclopropyl-7-[(S,S)-2,8-Diazabicyclo[4.3.0]Non-8-Yl]-6-Fluoro-8-Methoxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Di-P-Toluoyl-L-Tartarate置于盐酸,水体系中,用 乙醇 用作溶剂,化学反应 1.0H,以69.2%的收率获得莫西沙星盐酸盐一水合物
    参考文献:Ep1992626
    标题:Ep1992626

    海关参考信息

    专利信息


    专利号:US-8198451-B2
    优先权日:2006-11-13
    标题 :Process for the synthesis of moxifloxacin hydrochloride
    发明人：RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; PATHI SRINIVAS LAXMINARAYAN; PUPPALA RAVIKUMAR; GANGRADE MANISH; KANATHALA SHASHIREKHA
    权利人:RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; PATHI SRINIVAS LAXMINARAYAN; PUPPALA RAVIKUMAR; GANGRADE MANISH; KANATHALA SHASHIREKHA; CIPLA LTD
    摘要:A new polymorph of moxifloxacin hydrochloride is described, together with a method for making the polymorph. In addition, new intermediates in the formation of moxifloxacin hydrochloride are described, having formulas (1) and (II):

    专利号:AU-2007320997-B2
    优先权日:2006-11-13
    标题:Process for the synthesis of moxifloxacin hydrochloride

    专利号:US-2010152229-A1
    优先权日:2006-11-13
    标题:Process for the Synthesis of Moxifloxacin Hydrochloride

    专利号:US-8207339-B2
    优先权日:2010-03-19
    标 题 :Process for preparing Moxifloxacin and salts thereof
    发明人：CASTELLIN ANDREA; PADOVAN PIERLUIGI; JIAGENG LIU; ZHOU YIBO; FENG LIN
    权利人:CASTELLIN ANDREA; PADOVAN PIERLUIGI; JIAGENG LIU; ZHOU YIBO; FENG LIN; ITALIANA SINT SPA
    摘要:The present invention relates to a process for the synthesis of Moxifloxacin of Formula (I) and salts thereof n nby means of a process providing the coupling reaction of 1-cyclopropril-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo -3-quinolinic acid or ester thereof with (4aS, 7aS) -octahydro-1H-pyrrole[3,4-b]pyridine using a magnesium salt.

    专利号:CA-2669427-A1
    优先权日:2006-11-13
    标 题:Process for the synthesis of moxifloxacin hydrochloride

    专利号:EP-2089388-B1
    优先权日:2006-11-13
    标 题:Process for the synthesis of moxifloxacin hydrochloride

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Attia TZ, Abbas AM, Nour El-Deen DAM, Omar MA. Zinc (II)-Chelation-Enhanced Spectrofluorimetric Determination of Moxifloxacin: Development, Validation, Application to Eye Drops, and Greenness Assessment. Luminescence. 2026 Apr;41(4):e70483. doi: 10.1002/bio.70483. 2006–. Moxifloxacin. 2026 Apr 15. 27(7):3057. doi: 10.3390/ijms27073057.
    5: Bock M, Van Hasselt JGC, Fuursted K, Ihlemann N, Gill S, Christiansen U, Bruun NE, Povlsen JA, Køber L, Høfsten DE, Fosbøl EL, Pries-Heje MM, Thomsen K, Rosenvinge FS, Torp-Pedersen C, Helweg-Larsen J, Tønder N, Iversen K, Bundgaard H, Moser C. Pharmacokinetic and Pharmacodynamic Evaluations of Oral Moxifloxacin for Enterococcus faecalis Endocarditis. Clin Microbiol Infect. 2026 Apr
    8:S1198-743X(26)00183-7. doi: 10.1016/j.cmi.2026.04.001. Epub ahead of print. 21(4):e0346333. doi: 10.1371/journal.pone.0346333.

    合成参考文献


    参考文献:10.1021/acs.jmedchem.8b00644
    摘要:Odagiri T, Inagaki H, Nagamochi M, Kitamura T, Komoriya S, Takahashi H. Design, Synthesis, and Biological Evaluation of Novel 7-[(3aS,7aS)-3a-Aminohexahydropyrano[3,4-c]pyrrol-2(3H)-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens. J. Med. Chem. 2018 Jul 31;61(16):7234–44. doi: 10.1021/acs.jmedchem.8b00644.
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