CAS: 177034-57-0; 4-((2-Isopropoxyethoxy)Methyl)Phenol

上下游产品

CAS号109-59-1 异丙氧基乙醇 | CAS号623-05-2 对羟基苯甲醇 | CAS号66722-57-4 2-[[4-[[2-(1-甲基... | CAS号99103-03-4 S(-)-Bisoprolol

异丙氧基乙醇,对羟基苯甲醇置于ytterbium (III) Trifluoromethanesulfonate N-Hydrate 乙酸乙酯,Brine,Sodium Sulfate-Iii,Silica Gel,正己烷体系中,用 水 用作溶剂,化学反应 1.5H,反应生成4-异丙氧基乙氧基甲基酚
参考文献:Novel Aromatic Compound And Use Thereof
标题:Novel Aromatic Compound And Use Thereof
摘要:提供的是一种具有促进骨形成作用(和/或抑制骨吸收作用)的化合物.公式(i)或其药理学上可接受的盐,[其中每个取代基如描述中所定义],具有低毒性,显示非常好的药代动力学,具有促进骨形成的作用,并可用于预防或治疗代谢性骨疾病(骨质疏松症,纤维性骨炎(甲状旁腺功能亢进症),软骨病,影响系统性骨代谢参数的帕吉特病等),与骨吸收能力相比,其骨形成能力下降.

专利信息

专利号:WO-2016135616-A1
优先权日:2015-02-27
标题:An improved process for the preparation of bisoprolol and its intermediate
发明人：MORTHALA RAGHAVENDAR RAO; GHARPURE MILIND; JAGTAP ASHUTOSH; MHASKAR MAHESH; KRISHNMURTHY DHILEEPKUMAR
权利人:PIRAMAL ENTPR LTD
摘要:The present invention provides an improved process for the preparation of 4-((2-isopropoxy ethoxy) methyl) phenol compound (I), used as an intermediate in many organic synthesis; particularly a key intermediate for the synthesis of l-[4[2(l-methylethoxy) ethoxy methyl] phenoxy]-3-(l-methylethylamino)-propan-2-ol; commonly known as Bisoprolol or its pharmaceutically acceptable salts. The process comprises reacting the 4-hydroxybenzyl alcohol (II) with the 2-isopropoxyethanol (III) in the presence of activated silica and optionally, in the presence of solvent.

专利号:US-6087512-A
优先权日:1996-09-18
标题:Process for preparation of glycidyl ether
发明人：FURUKAWA YOSHIRO; KITAORI KAZUHIRO; YANAGIMOTO TETSUYA; MIKAMI MASAFUMI; YOSHIMOTO HIROSHI; OTERA JUNZO
权利人:DAISO CO LTD
摘要:A process for preparation of a glycidyl ether which is characrelized in reacting an epoxy compound of the formula ##STR1## wherein X is halogen or sulfonyloxy in the presence of a fluoride salt, with an alcohol. According to the above method, glycigyl ethers or their optically active compounds important as intermediates for synthesis of medicines are easily obtained in good yield and especially the optically active compounds are obtained with highly optical purity.

专利号:US-6057476-A
优先权日:1996-09-18
标题:Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers
发明人：FURUKAWA YOSHIRO; KITAORI KAZUHIRO; MIKAMI MASAFUMI; YOSHIMOTO HIROSHI; OTERA JUNZO
权利人:DAISO CO LTD
摘要:A process for preparation of 3-amino-2-hydroxy-1-propyl ether of the formula ##STR1## wherein R 1 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclic ring, R 2 and R 3 are the same or different hydrogen atom, a substituted or unsubstituted alkyl, or may form a ring together with an adjacent nitrogen atom, which ring may be interrupted with nitrogen atom, oxygen atom or sulfur atom, n which is characterized in reacting an epoxy compound of the formula ##STR2## wherein X is halogen, in the presence of a fluoride salt, with an alcohol and then reacting an amine. n According to the above method, an intermediates for synthesis of medicines is obtained in good yield and highly optical purity.

专利号:WO-2007069266-A3
优先权日:2005-12-12
标题 :A novel process for the synthesis of bisodprolol and its intermediate
发明人：RAMAKRISHNAN ARUL; AJAY DAYALJI CHAUHAN; RAJESH HARSHNATH PATHAK; RUCHI AGARWAL
权利人:UNICHEM LAB LTD; RAMAKRISHNAN ARUL; AJAY DAYALJI CHAUHAN; RAJESH HARSHNATH PATHAK; RUCHI AGARWAL
摘要:This invention relates to a manufacturing process for the preparation of bisoprolol and its pharmaceutically acceptable salt as well as its intermediates. The intermediate 4-[(2-isopropoxyethoxy)methyl]phenol is prepared by reaction of 4-hydroxybenzyl alcohol with 2-isopropoxy ethanol in presence of Amberlyst 15 in high yield with high purity.

专利号:CN-104876806-A
优先权日:2015-05-26
标 题:A new method for the synthesis of important intermediates of bisoprolol

专利号:WO-2007069266-A2
优先权日:2005-12-12
标 题 :A novel process for the synthesis of bisodprolol and its intermediate