CAS: 15801-69-1; 4-Bromo-1,3,5-Trimethyl-1H-Pyrazole

相似化合物

5775-86-0 5775-82-6 1454852-95-9

上下游产品

1,3,5-trimethyl-1H-pyrazole 4-Bromo-3,5-dimethylpyrazole methyl bromide 1,3,5-trimethyl-1H-pyrazole-4-carboxylic acid 1,3,5-trimethyl-4-dimethylphenylsilylpyrazole (1,3,5-trimethyl-1H-pyrazol-4-yl)boronic acid 1-(1,3,5-trimethyl-1-pyrazol-4-yl)-2-[2-methyl-5-(3-methoxyphenyl)-1-thien-3-yl]perfluor°Cyclopentene

1,3,5-三甲基吡唑置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙酸乙酯 用作溶剂,化学反应 0.1H,以86%的收率获得4-溴-1,3,5-三甲基吡唑
参考文献:一种使用n-卤代琥珀酰亚胺进行超声波照射的3,5-二甲基吡唑卤化的温和有效方法
标题:一种使用n-卤代琥珀酰亚胺进行超声波照射的3,5-二甲基吡唑卤化的温和有效方法
摘要:在无催化剂的情况下,通过3,5-二甲基吡唑与n-卤代琥珀酰亚胺(nbs,Ncs和nis)在超声辐射下的反应,可以在较短的反应时间内以较短的反应时间合成4-卤代3,5-二甲基吡唑..最后,在相似的条件下显示出用br 2,Icl和i 2卤化吡唑.
Doi:10.1016/j.Tetlet.2005.08.027

专利信息

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.