专利号:US-7309799-B2 优先权日:2004-06-01 标 题:Methods for the synthesis of milnacipran and congeners thereof 发明人:BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V 权利人:COLLEGIUM PHARMACEUTICAL INC 摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.
专利号:US-2003072716-A1 优先权日:2001-06-22 标 题:Renewable, carbohydrate based CO2-philes 发明人:POOVATHINTHODIYIL RAVEENDRAN; WALLEN SCOTT L 摘要:A composition is disclosed comprising a carbohydrate-based material a dispersed in carbon dioxide. A general method for synthesizing inexpensive, renewable, non-toxic, non-fluorous, carbohydrate based CO 2 -philes is disclosed. These CO 2 -philes are soluble in carbon dioxide. Methods of making the composition are also disclosed. The methods and composition are useful in a variety of applications and can utilize gaseous, liquid and supercritical carbon dioxide. The methods and compositions are useful in the synthesis of surfactants and metal chelates for CO 2 , as a sizing substrate, in CO 2 -based coating processes, for impregnation and plasticizing cellulosic and non-cellulosic materials, in pharmaceutical applications, such as crystallization, dispersion and encapsulation of bioactive molecules in solid systems, in the densification of CO 2 , in the synthesis of biodegradable polymers in CO 2 , and for carbon dioxide removal, to name just a few.
专利号:US-9896523-B2 优先权日:2015-06-26 标题 :Ziegler-Natta catalyst synthesis and process thereof 发明人:SINGH GURMEET; KUMAR NARESH; KAUR SUKHDEEP; BANTU BHASKER; KAPUR GURPREET SINGH; SHASHIKANT 权利人:INDIAN OIL CORP LTD 摘要:The present invention describes a process of preparing a catalyst for olefin polymerization comprising: (i) treating a magnesium metal with an organohalide along with an internal donor to obtain a reaction mixture having solid component (A); (ii) treating the reaction mixture having solid component (A) with an acyl halide to obtain a reaction mixture having solid component (B); and (iii) treating the reaction mixture having solid component (B) of step (ii) with a transition metal compound to obtain the catalyst. The present invention also relates to a process for preparation of a catalyst system from said catalyst and preparation of a polyolefins from the catalyst system.
专利号:US-2005282898-A1 优先权日:2004-06-01 标 题 :Methods for the synthesis of milnacipran and congeners thereof
专利号:US-7977269-B2 优先权日:2005-07-21 标 题:Diimine metal complexes, methods of synthesis, and methods of using in oligomerization and polymerization 发明人:SMALL BROOKE L; CARNEY MICHAEL 权利人:CHEVRON PHILLIPS CHEMICAL CO 摘要:Novel α-diimine metal complexes, particularly iron complexes, having a phenyl sulfidyl or substituted phenyl sulfidyl metal complexing group are disclosed. The α-diimine metal complexes having a phenyl sulfidyl or substituted phenyl sulfidyl metal complexing group are produced by forming one of the α-diimine metal complex imine bonds in the presence of a metal salt or an α-acylimine metal complex. The α-diimine metal complexes having phenyl sulfidyl or substituted phenyl sulfidyl metal complexing group are useful for polymerizing or oligomerizing olefins.
专利号:US-8940928-B2 优先权日:2012-02-15 标 题:Method of synthesizing levorotatory p-hydroxyphenylglycine compounds 发明人:XIE JIANZHONG; GUO XIUBIN; ZHAO LIXIAN; LIU CHAO 权利人:XIE JIANZHONG; GUO XIUBIN; ZHAO LIXIAN; LIU CHAO; HENAN NEWLAND PHARM CO LTD 摘要:The present invention relates to the field of chemical synthesis, particularly to a method of synthesizing levorotatory p-hydroxyphenylglycine compounds, which eliminates the subsequent processes of resolution, racemization processings, etc., simplifies operational steps; and acids with small organic molecule are chosen as catalyst in the second step, which not only is conducive to the realization of a industrialized production, but also makes the ee value of the end products be 88.1Ëœ98.0% by determining the catalyst, the reaction solvent, the reactive substance, the reaction temperature, and the reaction duration; non-aqueous solvent is used in the second step, to avoid the discharging of phenol-containing waste water, thus environmental pollution is reduced.
[参考文献]: Eva Hevia, Et Al. Direct Lateral Metallation Using Alkali-Metal Mediated Zincation (Ammzn): Sic-H Vs.Si-O Bond Cleavage. Chem Commun (Camb). 2009 Jun 14:(22):3240-2.
合成参考文献
摘要:Giel, M.-C.; Smedley, C. J.; Moses, J. E., Science of Synthesis, (2021) , 442. 摘要:Giel, M.-C.; Smedley, C. J.; Moses, J. E., Science of Synthesis, (2021) , 437.