3,5-二氟苄醇置于硫酸,氢溴酸体系中,化学反应生成3,5-二氟溴苄 参考文献:Fluorine-Substituted-4-Alkenylbenzoic Acid And Derivatives Thereof,And Nematic Liquid Crystal Composition Containing Cyanophenyl Benzoate Derivatives And Liquid Crystal Display System Using The Same 标题:Fluorine-Substituted-4-Alkenylbenzoic Acid And Derivatives Thereof,And Nematic Liquid Crystal Composition Containing Cyanophenyl Benzoate Derivatives And Liquid Crystal Display System Using The Same 摘要:本文揭示了一种新型液晶化合物,一种向列型液晶组合物以及使用该组合物的液晶显示系统.该液晶化合物由通式(I)表示:其中r代表氢原子或具有1至7个碳原子的直链烷基基团,X,Y和z分别代表氢原子或氟原子.本发明的向列型液晶组合物即使在少量添加的情况下也能根据所需目的提供液晶材料,而不会破坏其他特性.
专利号:US-2009306392-A1 优先权日:2007-10-19 标题 :Gsm intermediates 发明人:HO CHIH YUNG 权利人:HO CHIH YUNG 摘要:The present invention relates the use of compounds having the general Formula I, wherein the definitions or R 1 and R 2 are provided in the specification. Said compounds of Formula I are useful for the synthesis of a variety of γ-secretase modulators, which are in turn useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.
专利号:US-9751877-B2 优先权日:2012-09-21 标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders 发明人:PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT 权利人:PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:US-6861523-B2 优先权日:2002-02-08 标 题 :1,3,5- trisubstituted-1,3,5-triazine-2,4,6-trione compounds and libraries 发明人:YU YONGPING; OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TORREY PINES INST 摘要:The solid-phase synthesis of individual 1,3-disubstituted and 1,3,5-trisubstituted-1,3,5-triazine-2,4,6-triones and libraries thereof from a resin is described. Reaction of resin-bound amino acids with isocyanates yields resin-bound ureas, which further react with chlorocarbonyl isocyanate to selectively afford the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones. Selective alkylation at the N-5 position of the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones produces a trisubstituted triazinetrione. The products are cleaved from their solid support and obtained in good yield and purity.
专利号:US-12384771-B2 优先权日:2022-03-29 标题 :Pleuromutilin derivative containing thiazole-pyridine benzyl quaternary ammonium salt side chain and preparation method and use thereof 发明人:LIANG CHENGUAN; Kang Kairui; KE CHANGHUA; WANG YANZI; LIU YUTING; Yang Xiuding; ZHOU YING; LI JIAXUAN 权利人:UNIV SHAANXI SCIENCE & TECH 摘要:The present invention discloses a pleuromutilin derivative containing thiazole-pyridine benzyl quaternary ammonium salt side chain and a preparation method and use thereof and belongs to the field of medicinal chemistry. A pleuromutilin derivative with thiazole-pyridine benzyl quaternary ammonium salt side chain is successfully prepared by structural reconstruction of pleuromutilin and then structural modification with a quaternary ammonium salt compound. This compound synthesis method has the advantages of easily available raw materials, simple operation and high product yield, and is suitable for industrial production. The results of in vitro pharmacological experiments show that the pleuromutilin derivative of the present invention have good antibacterial and anti-mycoplasma activities, as well as good solubility, and these results show that the pleuromutilin derivative is of great value in the development of an anti-pathogenic microorganism drug.
专利号:RU-2130011-C1 优先权日:1993-06-16 标题 :Alicyclic compounds, a method of their synthesis, a pharmaceutical composition showing anti-inflammatory activity and a method of treatment of patients with inflammation
专利号:CN-119954778-A 优先权日:2025-01-27 标题 :Synthesis method of lenacipam sodium and series of intermediate compounds thereof
[参考文献]: Wei-Chun Chang, Et Al. Highly Efficient N-Heterocyclic Carbene/pyridine-Based Ruthenium Sensitizers: Complexes For Dye-Sensitized Solar Cells. Angew Chem Int Ed Engl. 2010 Oct 25;49(44):8161-4.
合成参考文献
摘要:Virieux, D.; Ayad, T.; Pirat, J.-L.; Volle, J.-N., Science of Synthesis Knowledge Updates, (2018) 1, 268. 摘要:Pitaval, A.; Echavarren, A. M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 592. 摘要:Caron, S.; Lee, J.; Liu, Y.; Nguyen, T. N.; Piper, J. L.; Vicini, A. C., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2. 参考文献:10.1107/s160053681003120x 摘要:Ma YT, Shi XW, Shuai Q, Gao JM. 1-[2-(3,5-Difluoro-benz-yloxy)phen-yl]ethanone. Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 11;66(Pt 9):o2293. 参考文献:10.1107/s1600536810033787 摘要:Ma YT, Zhang AL, Yuan MS, Gao JM. 1-[4-(3,5-Difluoro-benz-yloxy)-2-hy-droxy-phen-yl]ethanone. Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 28;66(Pt 9):o2468.