CAS: 137618-48-5; Tert-Butyl (2,3-Dihydroxypropyl)Carbamate

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上下游产品

CAS号616-30-8 3-氨基-1,2-丙二醇 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号190840-29-0 (2,3-Diazidopro... | CAS号89711-08-0 N-B°C-2-氨基乙醛

📜Tert-Butyl[((+/-)-2,2-Dimethyl-1,3-Dioxolan-4-yl)Methyl]Carbamate置于叔丁基过氧化氢体系中,用 水,叔丁醇 用作溶剂,化学反应 12.0H,以76%的收率获得n-(2,3-二羟基丙基)氨基甲酸叔丁酯
参考文献:在水介质中使用叔丁基过氧化氢对末端缩酮进行无金属脱保护
标题:在水介质中使用叔丁基过氧化氢对末端缩酮进行无金属脱保护
摘要:使用水性叔丁基过氧化氢 (70%) 作为廉价试剂开发了一种有用的方法,用于在水性介质中对末端丙酮化物基团进行区域选择性和化学选择性脱保护.多种丙酮衍生物与水:叔丁醇 (1:1) 中的叔丁基氢过氧化物水溶液反应,以非常好的收率提供相应的丙酮脱保护二醇.发现大量酸不稳定保护官能团和其他官能部分在本脱保护所采用的条件下不受影响.该方法已成功应用于糖衍生物.
Doi:10.1055/s-0030-1259917

专利信息

专利号:US-2005215801-A1
优先权日:2002-06-28
标 题 :Process for preparation of optically active 1-substituted amino-2,3-epoxypropanes, intermediates for synthesis thereof and process for preparation of the intermediates
发明人：KITAJIMA KUMI; NAGASHIMA NOBUO
权利人:KITAJIMA KUMI; NAGASHIMA NOBUO
摘要:The present invention provides an industrial process for effectively and advantageously preparing optically active 1-substituted amino-2,3-epoxypropanes useful as intermediates for preparing agricultural chemicals and medical products from optically active 1-substituted amino-2,3-propanediols used as raw materials. The present invention also provides useful intermediates. Specifically, an optically active 1-substituted amino-2,3-propanediol (1) is reacted with an orthoacid ester (2) or thionyl chloride (3) to produce a cyclic optically active compound (4), and then a compound (5) containing a halogen atom is prepared by reaction with a ring-opening reaction agent having an ability to introduce a halogen atom X. Finally, an optical active 1-substituted amino-2,3-epoxypropane is prepared by ring-closure reaction in the presence of a base.

专利号:EP-1553093-A1
优先权日:2002-06-28
标 题 :Process for preparation of optically active 1-substituted amino-2,3-epoxypropanes, intermediates for the synthesis thereof and process for preparation of the intermediates