CAS: 133-49-3; Pentachlorothiophenol

该化合物是一种氯化芳香化合物,其特点是,五氯原子存在于硫酚结构中,这种化合物一般在室内温度下是固体的,以其暗色而著称,经常以黑或深褐色粉末形式出现.五氯苯酚主要用于各种用途,包括农业和工业环境,作为生物杀灭剂和杀真菌剂;其化学结构有助于其稳定性和抗降解,使其有效控制微生物生长;然而,由于其高氯含量,它对环境和健康构成风险,包括对水生生物的潜在毒性和生物累积性的关切.因此,许多地区都对其使用进行管制,在处理该物质时必须采取安全防范措施.

结构式图片

相似化合物

1122-41-4 5858-17-3 5858-18-4

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

hexachlorobenzene 2,3,4,5,6-pentachloroaniline pentachlorophenylsulphenyl chloride IsobutaneS-pentachlorophenyl esterfuran-2-carbothioic acid S-pentachlorophenyl ester trithi°Carbonic acid bis-pentachlorophenyl ester 2-pentachlorophenylsulfanyl-ethylamine pentachlorophenylsulphenyl chloride

合成工艺路线路线简述

  • 合成目标产物 Pentachlorothiophenol 主要起始原料 Hexachlorobenzene
  • (文献来源)合成步骤主要原料 Hexachlorobenzene
五氯苯胺置于盐酸,溶剂黄146,Sodium Nitrite体系中,化学反应生成五氯苯硫酚
参考文献:Tadros; Saad,Journal Of The Chemical Society,1954,P. 1155
标题:Tadros; Saad,Journal Of The Chemical Society,1954,P. 1155

海关参考信息

专利信息


专利号:WO-9915510-A1
优先权日:1997-09-24
标 题:Protecting and linking groups for organic synthesis
发明人:TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY
权利人:ALCHEMIA PTY LTD; TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY
摘要:This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups which are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis. In its most general aspect, the invention provides a cyclic compound of general formula (I).

专利号:US-6765089-B1
优先权日:1997-09-24
标 题 :Protecting and linking groups for organic synthesis on solid supports
发明人:TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY
权利人:ALCHEMIA PTY LTD
摘要:This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups that are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis.

专利号:WO-2024142008-A1
优先权日:2022-12-29
标 题:A process for the preparation of 2,2' dithiobisbenzanilide
发明人:JAYABALAN LAKSHMANAN; NAMBOODIRI JANARDANAN KAPYUR; CHAUDHURI MONOJIT
权利人:NITREX CHEMICALS INDIA LTD
摘要:The present disclosure relates to a process for the preparation of 2,2'- dithiobisbenzanilide The process involves the hydrolysis of benzothiazole, followed by subsequent oxidation, and the benzoylation of the resulting reaction products to yield 2,2'-dithiobisbenzanilide. The process of the present disclosure is a one-pot synthesis and uses a minimal amount of base for the synthesis of 2,2'-dithiobisbenzanilide. The process is simple, economical, eco-friendly, and commercially scalable.

专利号:WO-9955664-A1
优先权日:1998-04-24
标 题 :Preparation of carbocyclic compounds
发明人:BECKER MARK W; CHAPMAN HARLAN H; KELLY DAPHNE E; KENT KENNETH M; LEW WILLARD; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; SCHULTZE LISA M; YU RICHARD H; ZHANG LIJUN
权利人:GILEAD SCIENCES INC; BECKER MARK W; CHAPMAN HARLAN H; KELLY DAPHNE E; KENT KENNETH M; LEW WILLARD; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; SCHULTZE LISA M; YU RICHARD H; ZHANG LIJUN
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:US-2024132927-A1
优先权日:2020-12-02
标 题 :Modular glycan production with immobilized bionanocatalysts
发明人:CORGIE STEPHANE CEDRIC; HOEPKER ALEXANDER CHRIS
权利人:ZYMTRONIX CATALYTIC SYSTEMS INC
摘要:The invention provides modular cell-free de-novo synthesis of glycans with immobilized bionanocatalysts. The invention provides materials, and in particular, magnetic materials, for producing glycans of defined length and sequences using one or more enzymes that are immobilized within bionanocatalysts (BNCs) which in turn are embedded within scaffolds to control the synthesis in batch or continuous processes manufacturing. In some embodiments, the scaffolds are high magnetism and high porosity composite blends of thermoplastics or thermosets comprising magnetic particles that form powders. In some embodiments, Selective Laser Sintering (SLS) is used to design and produce objects via 3D printing by sintering composite magnetic powders. The modular flow cells may be mixed and matched for a highly customizable and highly efficient cell-free manufacturing process. In some embodiments the elementary and system modules provided by the invention are employed. In preferred embodiments, human milk oligosaccharides (HMOs) are produced.

专利号:US-7749106-B2
优先权日:2006-03-30
标题 :Molded rubber material for golf ball, method of making the material and golf ball
发明人:SHINDO JUN; NANBA ATSUSHI
权利人:BRIDGESTONE SPORTS CO LTD
摘要:A molded rubber material for a golf ball is obtained by molding and vulcanizing a rubber composition composed of (a) a diene rubber, (b) an α,β-unsaturated carboxylic acid and/or a metal salt thereof, (c) an organic peroxide, and (d) an inorganic oxide. The inorganic oxide is prepared by a plasma process, a laser process or flame synthesis, has an average particle size of at most 200 nm, and is added in an amount of at least 1 wt % based on the zinc acrylate. The molded rubber material has a high hardness, a good resilience, and excellent durability.
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主要参考文献

[参考文献]: G Koss, Et Al. Conversion Products Of Hexachlorobenzene And Their Role In The Disturbance Of The Porphyrin Pathway In Rats. Int J Biochem. 1980;12(5-6):1003-6.
[参考文献]: J To-Figueras, Et Al. Studies On Sex Differences In Excretion Of Sulphur Derivatives Of Hexachlorobenzene And Pentachloronitrobenzene By Rats. Toxicol Lett. 1991 Apr;56(1-2):87-94.
[参考文献]: J To-Figueras, Et Al. Sulphur Derivative Of Hexachlorobenzene In Human Urine. Hum Exp Toxicol. 1992 Jul;11(4):271-3.
[参考文献]: M D'Amour, Et Al. Sex-Related Difference In Hepatic Glutathione Conjugation Of Hexachlorobenzene In The Rat. Toxicol Appl Pharmacol. 1992 Feb;112(2):229-34.
[参考文献]: N Legault, Et Al. Effect Of Estradiol On The Induction Of Porphyria By Hexachlorobenzene In The Rat. Biochem Pharmacol. 1997 Jul 1;54(1):19-25.

合成参考文献


摘要:European Commission/European Chemical Substances Information System (ESIS); IUCLID Dataset, Pentachlorobenzenethiol (CAS 133-49-3) p.9 (2000). Available from, as of February 27, 2015:
摘要:40 CFR 712.30 (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of February 25, 2015:
摘要:Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V2: 1244
摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
摘要:NIOSH; NOES. National Occupational Exposure Survey conducted from 1981-1983. Estimated numbers of employees potentially exposed to specific agents by 2-digit standard industrial classification (SIC). Available from, as of Mar 23, 2015 2009: https://www.cdc.gov/noes/
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