CAS: 13058-16-7; Z-Dl-Trp-Oh

该化合物是氨基酸锥虫受保护的衍生物,在氮位置上有一个碳苯并苯(Cbz)组,这种改变增强了稳定性,有利于在peptide合成中,特别是在固相和溶相方法中选择性反应.种族(DL)形式允许在手力分辨率研究或非立体应用中多功能性.Cbz组很容易在温和的氢解条件下切开,成为临时保护策略的实用选择.这种化合物通常用于制药研究,有机合成和复杂的peptide结构的建筑块.其一贯的纯度和可靠的再活动使得它成为合成化学家的宝贵试剂.

结构式图片

上下游产品

CAS号73504-30-0 4-nitrobenzyl (... | CAS号501-53-1 氯甲酸苄酯 | CAS号54-12-6 色氨酸 | CAS号7432-21-5 N-苄氧羰基-L-色氨酸 | CAS号2279-15-4 N-CBZ-D-色氨酸

合成工艺路线路线简述

    📜4-Nitrobenzyl ((Benzyloxy)Carbonyl)Tryptophanate置于sodium Dithionite,Sodium Carbonate体系中,用 乙腈 用作溶剂,以80%的收率获得苯甲氧羰基-Dl-色氨酸
    参考文献:Guibe-Jampel,E.; Wakselman,M.,Synthetic Communications,1982,Vol. 12,# 3,P. 219-224
    标题:Guibe-Jampel,E.; Wakselman,M.,Synthetic Communications,1982,Vol. 12,# 3,P. 219-224

    海关参考信息

    专利信息


    专利号:US-2006079497-A1
    优先权日:2004-10-12
    标题:Lavendamycin analogues and methods of synthesizing and using lavendamycin analogues
    发明人:BEHFOROUZ MOHAMMAD; BEHFOROUZ NANCY C
    权利人:BALL STATE UNIVERSITY
    摘要:Lavendamycin analogues, methods for their synthesis, and methods for their use in the treatment of diseases such as cancer and HIV infection are described.

    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

    专利号:EP-3320031-A1
    优先权日:2015-07-09
    标题:Synthesis of surface-functionalized polyamides

    专利号:US-6090250-A
    优先权日:1993-09-20
    标题 :Chiral surfactants and methods for their use in chiral separations
    发明人:MAZZEO JEFFREY R; GROVER EDWARD R; SWARTZ MICHAEL E; MERION MICHAEL; PETERSEN JOHN S
    权利人:WATERS INVESTMENTS LTD
    摘要:PCT No. PCT/US94/10655 Sec. 371 Date Mar. 20, 1996 Sec. 102(e) Date Mar. 20, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08529 PCT Pub. Date Mar. 30, 1995Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using nucellar capillary electrophoresis is disclosed. A chiral surfactant having the general formula: is described, R1 is the hydrophobic tail, Y-A-X is the linker, the brackets define a chiral center, and the hydrophilic head group is Z. All the various components may potentiate the enantioselectivity of the chiral surfactant. The capillary electrophoresis (CE) system includes a narrow diameter capillary, a high voltage power supply, an electrolyte reservoir at each end of the capillary, a means for injecting a sample, and a detector. Chiral surfactants are dissolved in the electrolyte above their critical micelle concentration (cmc), resulting in the formation of chiral micelles. The electrolyte reservoirs and capillary tube are filled with the electrolyte. A sample containing a mixture of enantiomers is then injected into the capillary, and a high voltage potential is applied across the capillary. The sample components migrate through the capillary due to the influence of the applied electric field. An example separation of the four sereoisomers of aspartame is shown.

    专利号:CN-106188231-B
    优先权日:2015-05-25
    标题 :Synthesis and application of pasireotide pentapeptide intermediate

    专利号:WO-2010103381-A1
    优先权日:2009-03-13
    标题 :Spirocyclic piperidine derivatives as trpm 8 modulators
    发明人:CHAUDHARI SACHIN SUNDARLAL; THOMAS ABRAHAM; KADAM ASHOK BHAUSAHEB; ADIK BHARAT GANGADHAR; DHONE SACHIN VASANTRAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
    权利人:GLENMARK PHARMACEUTICALS SA; CHAUDHARI SACHIN SUNDARLAL; THOMAS ABRAHAM; KADAM ASHOK BHAUSAHEB; ADIK BHARAT GANGADHAR; DHONE SACHIN VASANTRAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
    摘要:The present invention provides Transient Receptor Potential subfamily M, member 8 (TRPM8) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPM8. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPM8.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1134/s1061934818110114
    摘要:Shapovalova EN, Fedorova IA, Anan’eva IA, Shpigun OA. Macrocyclic Antibiotics as Chiral Selectors in High-Performance Liquid Chromatography and Capillary Electrophoresis. Journal of Analytical Chemistry. 2018 Nov 12;73(11):1064–75. doi: 10.1134/s1061934818110114.
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