专利号:US-2006079497-A1 优先权日:2004-10-12 标题:Lavendamycin analogues and methods of synthesizing and using lavendamycin analogues 发明人:BEHFOROUZ MOHAMMAD; BEHFOROUZ NANCY C 权利人:BALL STATE UNIVERSITY 摘要:Lavendamycin analogues, methods for their synthesis, and methods for their use in the treatment of diseases such as cancer and HIV infection are described.
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:EP-3320031-A1 优先权日:2015-07-09 标题:Synthesis of surface-functionalized polyamides
专利号:US-6090250-A 优先权日:1993-09-20 标题 :Chiral surfactants and methods for their use in chiral separations 发明人:MAZZEO JEFFREY R; GROVER EDWARD R; SWARTZ MICHAEL E; MERION MICHAEL; PETERSEN JOHN S 权利人:WATERS INVESTMENTS LTD 摘要:PCT No. PCT/US94/10655 Sec. 371 Date Mar. 20, 1996 Sec. 102(e) Date Mar. 20, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08529 PCT Pub. Date Mar. 30, 1995Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using nucellar capillary electrophoresis is disclosed. A chiral surfactant having the general formula: is described, R1 is the hydrophobic tail, Y-A-X is the linker, the brackets define a chiral center, and the hydrophilic head group is Z. All the various components may potentiate the enantioselectivity of the chiral surfactant. The capillary electrophoresis (CE) system includes a narrow diameter capillary, a high voltage power supply, an electrolyte reservoir at each end of the capillary, a means for injecting a sample, and a detector. Chiral surfactants are dissolved in the electrolyte above their critical micelle concentration (cmc), resulting in the formation of chiral micelles. The electrolyte reservoirs and capillary tube are filled with the electrolyte. A sample containing a mixture of enantiomers is then injected into the capillary, and a high voltage potential is applied across the capillary. The sample components migrate through the capillary due to the influence of the applied electric field. An example separation of the four sereoisomers of aspartame is shown.
专利号:CN-106188231-B 优先权日:2015-05-25 标题 :Synthesis and application of pasireotide pentapeptide intermediate
专利号:WO-2010103381-A1 优先权日:2009-03-13 标题 :Spirocyclic piperidine derivatives as trpm 8 modulators 发明人:CHAUDHARI SACHIN SUNDARLAL; THOMAS ABRAHAM; KADAM ASHOK BHAUSAHEB; ADIK BHARAT GANGADHAR; DHONE SACHIN VASANTRAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL 权利人:GLENMARK PHARMACEUTICALS SA; CHAUDHARI SACHIN SUNDARLAL; THOMAS ABRAHAM; KADAM ASHOK BHAUSAHEB; ADIK BHARAT GANGADHAR; DHONE SACHIN VASANTRAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL 摘要:The present invention provides Transient Receptor Potential subfamily M, member 8 (TRPM8) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPM8. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPM8.