📜2-(1H-吡唑-3-基)-乙醇置于(S)-(-)-α-甲基苄胺,磷酸吡哆醛,β-烟酰胺腺嘌呤二核苷酸,异丙胺,腺嘌呤黄素体系中,用 Aq. Phosphate Buffer 用作溶剂,30.0 °C,101.33 Kpa 条件下,反应生成倍他唑 参考文献:Biocatalytic Access To Betazole Using A One-Pot Multienzymatic System In Continuous Flow 标题:Biocatalytic Access To Betazole Using A One-Pot Multienzymatic System In Continuous Flow 摘要:Betazole的主要胺是通过一种一锅式,连续流生物催化级联反应从醇合成的,使用了一个pbr承载着一个多酶共同固定化系统,具有恒定的o2供应,用于原位辅因子回收,产量为2.59 G L-1 H-1. Doi:10.1039/d1Gc01095F
专利信息
专利号:US-4761413-A 优先权日:1986-12-22 标 题:1,5-epoxy-2,3,4,5-tetrahydro-1H-3-benzazepins and use in treatment of ulcers 发明人:WACHTER MICHAEL P; KARANEWSKY DONALD S 权利人:ORTHO PHARMA CORP 摘要:The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.
专利号:US-4855426-A 优先权日:1986-12-22 标题:Process of preparing 1,5-epoxy-2,3,4,5-tetrahydro-1H-3-benzazepins 发明人:WACHTER MICHAEL P; KARANEWSKY DONALD S 权利人:ORTHO PHARMA CORP 摘要:The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.
专利号:US-10874646-B2 优先权日:2015-10-16 标 题 :Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof 发明人:NICOLAOU KYRIACOS C; RHOADES DEREK; WANG YANPING; TOTOKOTSOPOULOS SOTIRIOS 权利人:UNIV RICE WILLIAM M 摘要:In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
专利号:US-7078406-B2 优先权日:2001-10-09 标 题 :Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes 发明人:CARVER JR THEODORE E; RINKER JAMES M 权利人:JOHNSON & JOHNSON PHARM RES 摘要:The present invention is directed to a compound of Formula I: n nwherein A, R 1 , and R 2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.
专利号:US-4910198-A 优先权日:1986-12-22 标题:1,5-epoxy-2,3,4,5-tetrahydro-1H-3-benzazepins 发明人:WACHTER MICHAEL P; KARANEWSKY DONALD S 权利人:ORTHO PHARMA CORP 摘要:The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.
专利号:MX-PA04003451-A 优先权日:2001-10-09 标 题:SUBSTITUTED DIFENYLOXAZOLS, THE SYNTHESIS OF THE SAME AND THE USE OF THE SAME AS FLUORESCENCE DETECTORS.
1: Noguchi Y, Ito M, Katsumi K, Yokoyama Y, Yasue N, Miyamoto T, Joh T, Takeuchi T. Effects of cyclic nucleotides, betazole hydrochloride and acetylcholine on pepsinogen secretion from isolated rabbit gastric mucosa. Gastroenterol Jpn. 1986 Apr;21(2):129-34.
合成参考文献
摘要:F. Holmes and F. Jones. J. Chem. Soc. 1960, 2398. 参考文献:10.1007/bf01308144 摘要:Weinstock JV. Idiopathic isolated granulomatous gastritis spontaneous resolution without surgical intervention. Digestive Diseases and Sciences. 1980 Mar;25(3):233–5. doi: 10.1007/bf01308144. 参考文献:10.1007/s11894-007-0063-7 摘要:Marciano T, Wershil BK. The ontogeny and developmental physiology of gastric acid secretion. Curr Gastroenterol Rep. 2007 Dec;9(6):479–81. doi: 10.1007/s11894-007-0063-7. 参考文献:10.1007/bf01314045 摘要:Sack DA, Stephensen CB. Liberation of hydrogen from gastric acid following administration of oral magnesium. Digestive Diseases and Sciences. 1985 Dec;30(12):1127–33. doi: 10.1007/bf01314045. 参考文献:10.1007/bf02774830 摘要:Noguchi Y, Ito M, Katsumi K, Yokoyama Y, Yasue N, Miyamoto T, Joh T, Takeuchi T. Effects of cyclic nucleotides, betazole hydrochloride and acetylcholine on pepsinogen secretion from isolated rabbit gastric mucosa. Gastroenterol Jpn. 1986 Apr;21(2):129–34. doi: 10.1007/bf02774830.