专利号:US-3857842-A 优先权日:1970-05-06 标题:Process for preparing purine compounds by reaction of a carbonitrile with formic acid 发明人:ASAI N 权利人:SAGAMI CHEM RES 摘要:An improved process for preparing purine compounds of the formula WHEREIN X is selected from the group consisting of an amino and a hydroxy group, and Y is selected from the group consisting of an amino and a hydroxy group and hydrogen, which are useful as precursors for the synthesis of organic compounds, as well as a process for preparing a carboxyamide of the formula USEFUL AS AN INTERMEDIATE FOR THE SYNTHESIS OF THE ABOVE PURINE COMPOUNDS ARE
专利号:US-2008187918-A1 优先权日:2004-11-19 标题 :Method of Diagnosing the Risk of Thermolabile Phenotype Diseases by Using Gene 发明人:KIDO HIROSHI; KINOSHITA MORITOSHI; MIZUGUCHI HIROSHI; TAKAHASHI NORIHIKO 权利人:OTSUKA PHARMA CO LTD; UNIV TOKUSHIMA 摘要:The invention relates to a method of diagnosing a risk of a thermolabile phenotype disease including or caused by influenza encephalitis/encephalopathy, Reye's syndrome, RS virus infectious disease, adenovirus infectious disease, rhinovirus infectious diseases, bastard measles, Japanese encephalitis, malaria infectious disease, Kawasaki disease and sudden infant death syndrome, characterized by examining whether or not an enzymatic activity of at least one enzyme involved in any of various transporters, carnitine cycle, long-chain β oxidation cycle, medium-chain/short-chain β oxidation cycle, electron transfer, synthesis of a ketone and production of ATP involved in energy metabolism in mitochondria is significantly lower compared with healthy subjects at 39° C. or higher when referring the enzymatic activity at 37° C. as to 100%.
专利号:US-9079951-B2 优先权日:2005-09-08 标 题 :Method for production of vitamin C 发明人:CHEVREUX BASTIEN; HAUK CORINA; MUFFLER ANDREA; MOUNCEY NIGEL J; SHINJOH MASAKO 权利人:CHEVREUX BASTIEN; HAUK CORINA; MUFFLER ANDREA; MOUNCEY NIGEL J; SHINJOH MASAKO; DSM IP ASSETS BV 摘要:The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of the polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of the polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in the microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
专利号:US-3948726-A 优先权日:1973-10-01 标题:Production of cephalosporin C 发明人:KANZAKI TOSHIHIKO; FUJISAWA YUKIO; SUIDE HARUO 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:A new process for the production of Cephalosporin C (CPC) in which a polyene-antibiotics-resistant mold of the genus Cephalosporium is employed and an increased yield is attained. n Cpc is an antibiotic and also useful as a starting material for the synthesis of Cephalosporin-group antibiotics.
专利号:WO-2006084730-A1 优先权日:2005-02-11 标题:Oxidoreductase gene from the respiratory chain system of gluconobacter oxydans 发明人:CHEVREUX BASTIEN; MAYER ANNE FRANCOISE; MEURY ANJA; MOUNCEY NIGEL JOHN; SHINJOH MASAKO 权利人:DSM IP ASSETS BV; CHEVREUX BASTIEN; MAYER ANNE FRANCOISE; MEURY ANJA; MOUNCEY NIGEL JOHN; SHINJOH MASAKO 摘要:The present invention relates to newly identified genes that encode proteins with oxidoreductase activity (e.g. EC 1.10) that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C) . The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as bioteσhnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
专利号:US-3808225-A 优先权日:1970-12-09 标 题:Process for the preparation of 4(5)-cyanoimidazole-5(4)-carboxyamide by reacting diaminomaleonitrile with formic acid 发明人:ASAI N 权利人:SAGAMI CHEM RES 摘要:AN IMPROVED PROCESS FOR THE PREPARATION OF 4(5)-CYANOIMIDAZOLE-5(4)-CARBOXYAMIDE OF THE FORMULA 4-(NC-),5-(NH2-CO-)IMIDAZOLE WHICH IS USEFUL AS A PRECUSOR FOR THE SYNTHESIS OF VARIOUS COMPOUNDS COMPRISING REACTING DIAMINOMALEONITRILE OF THE FORMULA NC-C(-NH2)=C(-NH2)-CN WITH FORMIC ACID IN AN AROMATIC SOLVENT IS DISCLOSED.
1: Shoji M, Arakaki Y, Esumi T, Kohnomi S, Yamamoto C, Suzuki Y, Takahashi E, Konishi S, Kido H, Kuzuhara T. Bakuchiol Is a Phenolic Isoprenoid with Novel Enantiomer-selective Anti-influenza A Virus Activity Involving Nrf2 Activation. J Biol Chem. 2015 Nov 13;290(46):28001-17. doi: 10.1074/jbc.M115.669465. Epub 2015 Oct 7. 2: Mao H, Wang H, Ma S, Xu Y, Zhang H, Wang Y, Niu Z, Fan G, Zhu Y, Gao XM. Bidirectional regulation of bakuchiol, an estrogenic-like compound, on catecholamine secretion. Toxicol Appl Pharmacol. 2014 Jan 1;274(1):180-9. doi: 10.1016/j.taap.2013.11.001. Epub 2013 Nov 11. doi: 10.1016/j.bbrc.2016.03.127. Epub 2016 Mar 28. doi: 10.1016/j.fitote.2015.09.005. Epub 2015 Sep 5. doi: 10.1155/2015/918624. Epub 2015 Nov 8. 7: Kim JE, Kim JH, Lee Y, Yang H, Heo YS, Bode AM, Lee KW, Dong Z. Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase. Oncotarget. 2016 Mar 22;7(12):14616-27. doi: 10.18632/oncotarget.7524.
合成参考文献
参考文献:10.2174/157016310791162785 摘要:Yang H, Liu J, Dou QP. Targeting tumor proteasome with traditional Chinese medicine. Curr Drug Discov Technol. 2010 Mar;7(1):46–53.