CAS: 10176-66-6; 5,7-Dihydroxy-6,8-Dimethoxy-2-(4-Methoxyphenyl)-4H-Chromen-4-One

该化合物是一种主要存在于各种植物物种中,特别是基因*摩鲁斯* 的天然裂质化合物,其特点是独特的化学结构,包括一种稀树草骨,有助于其潜在的生物活动;Nevadensin展示了抗氧化性特性,可能有助于消除自由基,减少生物系统中的氧化性压力;此外,研究表明,它可能具有抗炎和抗微生物效应,从而引起药理研究的兴趣;该化合物溶于有机溶剂,其稳定性可能受到诸如pH和温度等因素的影响;作为植物防御机制的一部分,Nevadensin也可以发挥作用,有助于发现植物的颜色和口味;其潜在的健康惠益和在养分和药方面的应用是不断调查的领域,突出了天然化合物在现代医学中的重要性.

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CAS号481-53-8 桔皮素

合成工艺路线路线简述

    📜2,4,6-三羟基苯乙酮一水合物置于n-溴代丁二酰亚胺(Nbs),Sodium,Potassium Carbonate,Copper(Ll) Bromide体系中,用 N,N-二甲基甲酰胺,丙酮,三氟乙酸 用作溶剂,化学反应 30.17H,反应生成5,7-二羟基-6,8,4'-三甲氧基黄酮
    参考文献:一种石吊兰素的制备方法
    标题:一种石吊兰素的制备方法
    摘要:本发明提供的一种石吊兰素的制备方法,具有这样的特征,包括如下制备步骤:步骤一,采用间苯三酚和醋酸酐为反应原料,在三氟化硼乙醚的催化下进行friedel-crafts反应,得到2,4,6‑三羟基苯乙酮;步骤二,将步骤一得到的2,4,6‑三羟基苯乙酮和对甲氧基苯酰氯在碳酸钾的催化下进行成环反应,得到5,7‑二羟基‑4'‑甲氧基黄酮;步骤三,将步骤二得到的5,7‑二羟基‑4'‑甲氧基黄酮在nbs的催化下进行自由基反应,得到5,7‑二羟基‑6,8‑二溴‑4'‑甲氧基黄酮;步骤四,将步骤三得到的5,7‑二羟基‑6,8‑二溴‑4'‑甲氧基黄酮和甲醇钠在溴化亚铜的催化下进行甲氧基化反应,得到石吊兰素.

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    专利信息


    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:US-2020261485-A1
    优先权日:2015-12-16
    标题:Compositions comprising 3'-o-glucuronide epicatechin and methods of making and using such compositions
    发明人:ACTIS GORETTA LUCAS; PATIN AMAURY; MICHLIG GONZALEZ STEPHANIE; CAMACHO SUSANA; LEGRAND COLINE; LE COUTRE JOHANNES; CASTANEDA GUTIERREZ EURIDICE; SILVA ZOLEZZI IRMA
    权利人:NESTEC SA
    摘要:Compositions can comprise the flavanol metabolite 3′-O-glucuronide epicatechin (3GEC). In some embodiments, the amount of 3GEC is effective to increase energy expenditure, sympathetic nervous system activity, and/or fat oxidation. Such a composition can be used in a method to support weight management or promote weight loss, a method for preventing obesity or overweight, and a method for treating obesity or overweight. In some embodiments, the composition can improve insulin sensitivity, glucose tolerance, cognitive performance, cognition, mood and/or memory. In some embodiments, the composition can achieve a therapeutic effect selected from the group consisting of blood vessel dilation, reduced blood pressure, increased delivery of blood flow to tissues in the body, improvement of blood circulation, e.g. in brain, stimulation of protein synthesis, increased release of growth factors, enhanced immune function, and combinations thereof. In some embodiments, the composition can treat or prevent dysphagia, e.g., by provoking the swallowing reflex.

    专利号:CN-115612114-A
    优先权日:2021-07-14
    标 题:Method and application of copolymer film and its enzymatic self-assembly synthesis

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Al-Subeihi AA, Alhusainy W, Paini A, Punt A, Vervoort J, van Bladeren PJ, Rietjens IM. Inhibition of methyleugenol bioactivation by the herb-based constituent nevadensin and prediction of possible in vivo consequences using physiologically based kinetic modeling. Food Chem Toxicol. 2013 Sep;59:564-71. doi: 10.1016/j.fct.2013.06.043. Epub 2013 Jul 4. doi: 10.1016/j.jpba.2012.10.021. Epub 2012 Nov 1. doi: 10.1016/j.fct.2014.08.016. Epub 2014 Sep 10. doi: 10.1016/j.jpba.2017.11.029. Epub 2017 Nov 16. doi: 10.1016/j.taap.2010.02.017. Epub 2010 Mar 11. Erratum in: Toxicol Appl Pharmacol. 2010 Sep 15;247(3):250. doi: 10.1002/mnfr.201300144. Epub 2013 Jul 26. doi: 10.1016/j.jchromb.2018.03.032. Epub 2018 Mar 16. doi: 10.1074/jbc.M112.420448. Epub 2012 Nov 26.
    10: Wang YQ, Weng ZM, Dou TY, Hou J, Wang DD, Ding LL, Zou LW, Yu Y, Chen J, Tang H, Ge GB. Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1. Int J Biol Macromol. 2018 Dec;120(Pt B):1944-1954. doi: 10.1016/j.ijbiomac.2018.09.178. Epub 2018 Sep 27. doi: 10.1016/j.phytochem.2013.05.001. Epub 2013 Jun 6. doi: 10.1093/pcp/pcu152. Epub 2014 Nov 6. doi: 10.1016/j.jchromb.2011.06.035. Epub 2011 Jul 2. doi: 10.1016/j.fct.2013.08.019. Epub 2013 Aug 16. doi: 10.1080/17425255.2018.1484450. Epub 2018 Jun 11. Review. Chinese.

    合成参考文献


    参考文献:10.1016/j.jchromb.2011.06.035
    摘要:Tong X, Xiao X, Li G. On-line coupling of dynamic microwave-assisted extraction with high-speed counter-current chromatography for continuous isolation of nevadensin from Lyeicnotus pauciflorus Maxim. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Aug 15;879(24):2397–402. doi: 10.1016/j.jchromb.2011.06.035.
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