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📜2-羟基吡啶,三氟乙酸酐 反应生成 2-(三氟乙酰氧基)吡啶
参考文献:单羟基吡啶的一些正和邻酰基衍生物的质子和碳核磁共振研究
标题:单羟基吡啶的一些正和邻酰基衍生物的质子和碳核磁共振研究
摘要:一系列n和o-酰基取代的单羟基吡啶(c 5 H 4 Nor:R =-H,-Cho,-Coch 3,-Coc(ch 3)3,-Cocf的质子和碳NMR光谱的比较研究报道了3,-Coc 6 H 5,-So 2 Ch 3,-So 2 C 6 H 4 Ch 3 [P]特性1 H,13 NMR和ir光谱特征可对2-,3-和4-羟基吡啶的同分异构的n-和/或o-酰基衍生物进行简单而明确的区分,因此,由于互变异构,当互变异构发生平衡时,两种形式都可以清楚地鉴定出来.速度在NMR时间尺度上很慢
DOI:10.1016/0040-4020(84)85087-5

专利信息

专利号:US-9359366-B2
优先权日:2013-04-10
标 题 :Intermediate of Ticagrelor and preparation method therefor, and preparation method for Ticagrelor
发明人：SUN SHAOGUANG; SONG DEFU; HE BIAO; LAI XIAOBO
权利人:JIANGSU HENGRUI MEDICINE CO; SUNCADIA PHARMACEUTICALS CO LTD
摘要:Disclosed are intermediates of Ticagrelor and a preparation method therefor, and a preparation method for Ticagrelor. Specifically, disclosed is an intermediate, namely, a compound of Formula (VI), for preparing Ticagrelor. Further disclosed is a method for preparing the intermediate and a method for preparing Ticagrelor by using the intermediate. Ticagrelor is prepared by using the intermediate, so that the synthesis process is simple, and a defect that long reaction times under high temperature that are required in the existing methods are avoided. The method is suitable for mass production in industry, energy consumption is reduced, pollution of the environment is reduced, and discharge of waste is reduced.