CAS: 953039-63-9; 8-Bromo-2-Chloro-6-Fluoroquinazoline
该化合物是一种卤化的五氯苯衍生物,在制药和农用化学研究中具有重大效用,其多替代结构,以溴,氯和氟功能组为主,增强了反应性和选择性,使其成为合成复杂的七环化合物的宝贵中间体.这些卤素的存在通过交叉反应,核生殖替代或金属催化变异,可以进一步发挥作用.这种化合物在药用化学中特别有助于发展动脉抑制剂和其他生物活性分子.在标准条件下,它的高纯度和稳定性确保了合成应用的可靠性能.研究人员认为,在建造适合生物活动的药用药剂剂时,它具有多功能性.
- 英文名称8-Bromo-2-Chloro-6-Fluoroquinazoline
- 中文名称8-溴-2-氯-6-氟喹唑啉
- IUPAC名称8-bromo-2-chloro-6-fluoroquinazoline
- 其它别名8-溴-2-氯-6-氟喹唑啉; 8-溴-2-氯-6-氟苯 并嘧啶; 8-Bromo-2-Chloro-6-Fluoro-Quinazoline
- CAS编号953039-63-9
- MFCD编号:MFCD18382554
- 分子式:C8H3BrClFN2分子量:261.48
- 产品CID: 2006092
- 产品分类有机原料→分子砌块→芳杂环类化合物→喹唑啉类化合物
物理性质
MSDS等安全信息
上下游产品
CAS号953039-62-8 8-bromo-6-fluor...合成工艺路线路线简述
- 953039-62-8 = 953039-63-9
反应条件:1.1 Reagents: Phosphorus Oxychloride; 1 H,120 °C
标题:Preparation Of N-Substituted Heteroaryl Carboxamides As Ahr Antagonists Useful In Culturing And/or Expanding Stem Cells And/or Lineage Committed Progenitor Cells
参考文献:World Intellectual Property Organization]
953039-62-8 = 953039-63-9
反应条件:1.1 Reagents: Phosphorus Oxychloride; 1 H,120 °C1.2 Solvents: Water
标题:Preparation Of Heteroaryl Amides As Ahr Modulators
参考文献:World Intellectual Property Organization]
953039-62-8 = 953039-63-9
反应条件:1.1 Reagents: Phosphorus Oxychloride; 16 H,105 °C; 105 °C -> Rt
标题:Fused Ring Pyrimidine Compound,Intermediate,And Preparation Method,Composition And Use Thereof
参考文献:World Intellectual Property Organization]
953039-62-8 = 953039-63-9
反应条件:1.1 Reagents: Phosphorus Oxychloride; 1 H,Rt -> 110 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Ph 7,Cooled
标题:2-Arylaminoquinazolines As Pdki Inhibitors And Their Preparation And Use In The Treatment Of Proliferative Diseases
参考文献:World Intellectual Property Organization]
953039-62-8 = 953039-63-9
反应条件:1.1 Reagents: Phosphorus Oxychloride; Rt -> 110 °C; 1 H,110 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Ph 7,Cooled
标题:Preparation Of Quinazolines For Pdk1 Inhibition
参考文献:World Intellectual Property Organization]
57-13-6 + 953039-61-7 = 953039-63-9
反应条件:1.1 Rt -> 180 °C; 1.5 H,180 °C; 180 °C -> Rt1.2 Reagents: Phosphorus Oxychloride; 3 H,Reflux
标题:Substituted Piperazine Compound,Its Preparation Method And Application
参考文献:China]
953039-62-8 = 953039-63-9
反应条件:1.1 Reagents: Phosphorus Oxychloride; 16 H,105 °C
标题:Condensed-Ring Pyrimidylamino Derivatives,Preparation Method Therefor,And Intermediate,Pharmaceutical Composition And Applications In The Treatment Of Cancer
参考文献:World Intellectual Property Organization
📜2-氨基-3-溴-5-氟苯甲酸置于manganese(Iv) Oxide,硼烷四氢呋喃络合物,三氯氧磷体系中,用 四氢呋喃,氯仿 作为反应溶剂,化学反应 48.5H,反应生成 8-溴-2-氯-6-氟喹唑啉
参考文献:Fused Ring Pyrimidine Compound,Intermediate,And Preparation Method,Composition And Use Thereof
标题:Fused Ring Pyrimidine Compound,Intermediate,And Preparation Method,Composition And Use Thereof
摘要:揭示的区域融合环嘧啶化合物,以及中间体,制备方法,组合物及其用途.融合环嘧啶化合物是如下式i所示的化合物,其为互变异构体,对映异构体,顺反异构体,药学上可接受的盐,代谢物,代谢前体或其前药,上述化合物用于制备用于预防,缓解或治疗免疫系统疾病,自身免疫疾病,细胞增殖性疾病,过敏性疾病和心血管疾病中的一种或多种的药物,且该化合物对janues激酶,Fgfr激酶,Flt3激酶和src家族激酶具有强烈的抑制作用.
