CAS: 6968-11-2; (Z-Cys-Oh)2

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L-胱氨酸置于sodium Hydroxide,氯甲酸苄酯体系中,化学反应生成 N,N'-二(苄氧羰基)-L-胱氨酸
参考文献:合成的两性多肽.二,可逆收缩性两性多肽的合成及一些性质
标题:合成的两性多肽.二,可逆收缩性两性多肽的合成及一些性质
摘要:1. 合成了一种可逆收缩的两性多肽,Copoly-26:26:1-(l-谷氨酸,L-赖氨酸,Dl-胱氨酸).2. 该多肽的箔在其等电区收缩并在酸性和碱性介质中延伸.这种伸展和收缩是 Ph 依赖性的并且完全可逆.3. 在水性介质中使用高达每 1 厘米干重约 2,000 倍的载荷测量该箔条的载荷-伸长率关系.条的长度.这种关系在这个范围内是线性的.4. 温度-伸长率关系是在 20-50oc 的水性介质中测量的.从数据可以得出结论,在给定温度下,内能和熵随着带材的伸长而增加.5,带材在含水介质中长度的变化,含有盐酸,氢氧化钠,分别或成对测量氯化钠和其他一些中性盐.观测到了一些奇特而有趣的现象.
DOI:10.1246/bcsj.29.664

专利信息

专利号:US-7179794-B2
优先权日:1998-06-08
标题 :Multivalent macrolide antibiotics
发明人：GRIFFIN JOHN H; PACE JOHN L
权利人:THERAVANCE INC
摘要:Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.