专利号:WO-2014097257-A1 优先权日:2012-12-21 标 题:A method of preparation of (1'r,3r,4r)-4-acetoxy-3-(1'-(tert-butyldimethylsilyloxy)ethyl)-2-azetidinone, a precursor for carbapenem antibiotics synthesis 发明人:GRZESZCZYK BARBARA; STECKO SEBASTIAN; FURMAN BARTÅ?OMIEJ; CHMIELEWSKI MAREK 权利人:INST CHEMII ORGANICZNEJ PAN 摘要:The subject of the present invention is a method of preparation of (1'R,3R,4R)-4-acetoxy-3-(1'- (tert-butyl-dimethylsilyloxy)ethyl)-2-azetidinone defined by the formula (1) which is a basic chiral building block in the synthesis of carbapenem antibiotics.
专利号:US-10266467-B2 优先权日:2017-08-02 标 题:Synthesis of glycols via transfer hydrogenation of alpha-functional esters with alcohols 发明人:CHAKRABORTY SUMIT; HEMBRE ROBERT THOMAS 权利人:EASTMAN CHEM CO 摘要:A transfer hydrogenation process for forming vicinal diols by hydrogenating 1,2-dioxygenated organic compounds using alcohols as the reducing agent instead of the traditional H 2 gas. The transfer hydrogenation is carried out under milder conditions of temperature and pressure than is typical for ester hydrogenation with H 2 . The milder conditions of operation provide benefits, such as lower operating and capital costs for industrial scale production as well as savings in product purification due to the avoidance of by-products from exposure of reaction mixtures and products to high temperatures.
专利号:US-4536334-A 优先权日:1979-06-28 标题 :Preparation of β-lactam derivatives 发明人:SUNAGAWA MAKOTO; MATSUMURA HARUKI; INOUE TAKAAKI; HIROHASHI TOSHIYUKI 权利人:SUMITOMO CHEMICAL CO 摘要:A process for preparing a β-lactam derivative having a hydrogen atom on the nitrogen atom of the β-lactam ring, which comprises reacting a β-lactam derivative having a mono- or diarylmethyl group on the nitrogen atom of the β-lactam ring with an acid or ceric ammonium nitrate to cleave the bond between the nitrogen atom and the mono- or diarylmethyl group; and novel β-lactam derivatives useful as intermediates for the synthesis of pharmaceutical agents.
专利号:US-11225655-B2 优先权日:2010-04-16 标题:Bi-functional complexes and methods for making and using such complexes 发明人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK 权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS 摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
专利号:US-2019039978-A1 优先权日:2017-08-02 标 题:Synthesis of glycols via transfer hydrogenation of alpha-functional esters with alcohols
专利号:EP-1607389-A1 优先权日:1999-09-10 标题:4-protected-amino-2-substituted-1,2,3,4-tetrahydroquinolines as intermediates for CETP inhibitors 发明人:DENINNO MICHAEL PAUL; MAGNUS-ARYITEY GEORGE TETTEH; RUGGERI ROGER BENJAMIN; WESTER RONALD THURE 权利人:PFIZER PROD INC 摘要:The present invention relates to compounds of formulan nwherein P 2 , R 2 , R 5 , R 6 , R 7 and R 8 are as defined herein, which are useful as intermediates innthe synthesis of 4-carboxyarnino-2-substitated-1,2,3,4-tetrahydroquinolines.