CAS: 62312-55-4; 5-Hydroxy-2-Pyrrolidinone

相似化合物

123-56-8 39662-63-0 15438-71-8

上下游产品

5-methoxy-dihydro-furan-2-one 5-ethoxy-pyrrolidin-2-one 5-methoxypyrrolidin-2-one 5-chloro-1H-pyrrole-2-carboxaldehyde 5-chloropyrrole-2,4-dicarboxaldehyde 5-benzyloxy-2-pyrrolidinone

📜5-乙氧基-2-吡咯烷酮 以 水 作为反应溶剂,化学反应 3.0H,以60%的收率获得产物5-羟基-2-吡咯烷酮
参考文献:由(-)-长春新碱简单合成bannucine和5'-Epibannucine
标题:由(-)-长春新碱简单合成bannucine和5'-Epibannucine
摘要:Bannucine是一种从矢车菊(catharanthus Roseus)的干燥叶片中分离出的一种孢子生物碱.所述分子是文多灵带有c10取代基,图案共同的抗肿瘤二聚吲哚生物碱的衍生物长春花.在bannucine中,将2-吡咯烷酮部分在c5'处连接到在c10上的vindoline核心的芳香环.在目前的工作我们报告bannucine的合成和其来自天然5'-差向异构体(-)-文多灵使用环状ñ-Acyliminium离子,其中间体ñ-酰基氨基甲醇前体是通过琥珀酰亚胺的部分还原而合成的.我们还使用单晶x射线衍射方法描述了两种差向异构体的分离和结构分析,以阐明与c5'碳相连的质子的取向.还研究了纯差向异构体的体外抗肿瘤活性,但两种物质均未在所检查的肿瘤细胞系上显示出显着活性.
DOI:10.1016/j.Tet.2015.10.020

专利信息

专利号:WO-2013065066-A1
优先权日:2011-11-02
标 题 :Processes for preparing 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro [l,2,41-triazolo[43-a]pyrazin-7(8h)-yl]-l-(2,4,5- trifluorophenyl)butan-2-amine
发明人：PANDEY BIPIN; DAVE MAYANK GHANSHYAMBHAI; KOTHARI HIMANSHU M; SHUKLA BHAVIN SHRIPRASAD; MENDIRATTA SANJEEV KUMAR; JOSHI RUPAL; TRIVEDI UMANG
权利人:CADILA HEALTHCARE LTD; PANDEY BIPIN; DAVE MAYANK GHANSHYAMBHAI; KOTHARI HIMANSHU M; SHUKLA BHAVIN SHRIPRASAD; MENDIRATTA SANJEEV KUMAR; JOSHI RUPAL; TRIVEDI UMANG
摘要:The present invention relates to synthesis of 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro [l,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-l-(2,4,5-trifluorophenyl)butan-2- amine of Formula (I) either in its racemic (R/S) form or any of its optically active (S) or (R) forms or enantiomeric excess mixture of any of the forms by novel processes. The invention further relates to certain novel intermediates useful in the preparation of compound of Formula (I) and processes for their preparation.

专利号:WO-9640635-A1
优先权日:1995-06-07
标题:Novel 5-hydroxypyrrolidone-2 derivatives isolated from certain strains of penicillium and sclerophoma and their use as paf synthesis modulators

专利号:EP-3746452-B1
优先权日:2018-02-01
标题:Stereoselective synthesis and process for the manufacturing of 2'-deoxynucleosides