CAS: 57602-02-5; 1,14-Dibromo-3,6,9,12-Tetraoxatetradecane

该化合物是一种双功能聚乙烯甘醇衍生物,其末端都是四乙基甘醇空间仪的两端的末端溴组,该化合物因其反应性溴元素,在有机合成,生物合成和材料科学中广泛用作多用途链接器,从而能够高效地实现烷基化或核生殖替代反应.PEG4空间仪增强溶性,减少阻塞性,便利目标分子的受控修改.其对称结构确保了一致性的再活动性,使之适合脱光剂和聚合物的交叉使用或合成.Bromo-PEG4-溴化物在建立药物运载系统或改变生物分子的同时保持生物兼容性,在制药研究中特别有用.

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72713-23-6 67705-77-5 177987-04-1

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CAS号4792-15-8 五甘醇 | CAS号109789-39-1 五乙二醇二甲磺酸盐 | CAS号55400-73-2 Ms-PEG4-Ms | CAS号5197-65-9 Chloro-PEG5-chloride | CAS号112-60-7 三缩四乙二醇 | CAS号212262-08-3 3,6,9,12-四草酸酯十四... | CAS号89141-20-8 2-[2-[2-[2-(2-s...

合成工艺路线路线简述

    📜1,11-二(甲烷磺酰基氧基)-3,6,9-三氧杂十一烷置于lithium Bromide体系中,用 丙酮 作为反应溶剂,化学反应生成 1,14-二溴-3,6,9,12-四恶十四烷
    参考文献:Bifunctional Thiosialosides Inhibit Influenza Virus
    标题:Bifunctional Thiosialosides Inhibit Influenza Virus
    摘要:We Have Synthesized A Panel Of Bivalent S-Sialoside Analogues,With Modifications At The 4 Position,As Inhibitors Of Influenza Virus. These First Generation Compounds Show Ic50 Values Ranging From Low Micromolar To High Nanomolar In Enzyme Inhibition And Plaque Reduction Assays With Two Intact Viruses,Influenza H1N1 (A/california/07/2009) And H3N2 (A/hongkong/8/68). (C) 2013 Elsevier Ltd. All Rights Reserved.
    DOI:10.1016/j.Bmcl.2013.11.077

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    专利信息


    专利号:US-4348377-A
    优先权日:1979-08-09
    标题:New derivatives of 2,4,6-triiodo-isophthalic acid, proceses for their synthesis and X-ray contrasting materials containing these
    发明人：FELDER ERNST; PITRE DAVIDE
    权利人:BRACCO IND CHIMICA SPA
    摘要:Novel, radio-opaque compounds comprising water-soluble bis-[N-{3,5-bis-(hydroxyalkylaminocarbonyl)-2,4,6-triiodo-phenyl}-N-( alpha -hydroxyacyl)-amino]-alkanes are disclosed for use as X-ray contrast agents. These compounds are relatively simple to synthesize, possess low toxicity and have good stability as well as resistance to hydrolysis. Methods for preparation and use of the compounds are also disclosed.

    专利号:CA-1123009-A
    优先权日:1979-08-09
    标 题 :Derivatives of 2,4,6-triiodo-isophthalic acid, processes for their synthesis and x-ray contrasting materials containing these

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    主要参考文献


    1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3.
    2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. pii: E1190. doi: 10.3390/molecules22071190.
    4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. doi:10.1016/j.jconrel.2016.02.017. Epub 2016 Feb 8.

    合成参考文献


    摘要:Kellogg, R. M., Science of Synthesis, (2006) 8, 1501.
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