CAS: 565-20-8; N-(4-((4-Aminophenyl)Sulfonyl)Phenyl)Acetamide

该化合物是Dapsone(4,4'-二氨基苯基磺酸)的化学改良衍生物,主要功能之一是一个乙酰组,该改变增强了其代谢稳定性,并改变了其物理化学特性,使其成为药物研究和合成的宝贵中间体.该化合物保留了与Dapsone有关的一些生物活动,如抗炎和抗微生物效应,同时有可能提供更好的药用动力学特征.其乙酰结构还可能降低对代谢降解的易感性,扩大其在实验应用中的实用性.N-Acetyl Dapsone通常用于研究基于全氟辛烷磺酸的药物发展和行动机制.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

N-[4-(4-Nitro-benzenesulfonyl)-phenyl]-acetamide acetic anhydride dapsone acetic acidtrans-cinnamylidenamino-benzenesulfonyl-)-anilide]acetic acid-[4-(4-trans-cinnamylidenamino-benzenesulfonyl-)-anilide] (4-acetylamino-phenyl)-(4-formylamino-phenyl)-sulfone (4-acetylamino-phenyl)-(4-lauroylamino-phenyl)-sulfone N-ethyl-sulfanilyl)-anilide]acetic acid-[4-(N-ethyl-sulfanilyl)-anilide]

合成工艺路线路线简述

    📜4-乙酰氨基苯硫酚置于4-二甲氨基吡啶,Sodium Perborate,四(三苯基膦)钯,盐酸羟胺,Potassium Carbonate,溶剂黄146,N,N-二异丙基乙胺,N,N'-羰基二咪唑,对硝基苯磺酰氯,1,5-Diazabicyclo[5.4.0]Undec-5-Ene体系中,用 四氢呋喃,甲醇,二甲基亚砜,乙腈 作为反应溶剂,化学反应 28.5H,反应生成 N-乙酰氨苯砜
    参考文献: Process For The Synthesis Of Dapsone And Its Intermediates[fr] Procédé De Sythèse De Dapsone Et Intermédiaires De Celle-Ci
    标题: Process For The Synthesis Of Dapsone And Its Intermediates[fr] Procédé De Sythèse De Dapsone Et Intermédiaires De Celle-Ci
    摘要:描述了一种合成达氯酮和其中间体的过程.

    海关参考信息

    专利信息


    专利号:US-9845289-B2
    优先权日:2014-08-01
    标题 :Process for the synthesis of Dapsone and its intermediates
    发明人：BARATELLA MARCO; CASTALDI GRAZIANO; CASTALDI MARTA; GABOARDI MAURO; PALLANZA GIUSEPPE
    权利人:SEEGPHARM SA
    摘要:A process for the synthesis of Dapsone and intermediates thereof are described.

    专利号:US-2023297852-A1
    优先权日:2020-07-29
    标题:Multi-Stage Machine Learning Model Synthesis for Efficient Inference
    发明人：ZHANG LI; HOWARD ANDREW GERALD; JOU BRENDAN WESLEY; ZHU YUKUN; ZHANG MINGDA; ZHMOGINOV ANDREY
    权利人:GOOGLE LLC
    摘要:Example implementations of the present disclosure combine efficient model design and dynamic inference. With a standalone lightweight model, the unnecessary computation on easy examples is avoided and the information extracted by the lightweight model also guide the synthesis of a specialist network from the basis models. With extensive experiments on ImageNet it is shown that a proposed example BasisNet is particularly effective for image classification and a BasisNet-MV3 achieves 80.3% top-1 accuracy with 290 M MAdds without early termination.

    专利号:CA-2954566-A1
    优先权日:2014-08-01
    标 题 :Process for the synthesis of dapsone and its intermediates

    专利号:US-2017217883-A1
    优先权日:2014-08-01
    标题 :Process for the synthesis of dapsone and its intermediates

    专利号:EP-3180307-A1
    优先权日:2014-08-01
    标 题 :Process for the synthesis of dapsone and its intermediates

    专利号:EP-3180307-B1
    优先权日:2014-08-01
    标题:Process for the synthesis of dapsone and its intermediates

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    合成参考文献


    参考文献:10.1007/bf00562621
    摘要:Ahmad RA, Rogers HJ. Plasma and salivary pharmacokinetics of dapsone estimated by a thin layer chromatographic method. European Journal of Clinical Pharmacology. 1980 Mar;17(2):129–33. doi: 10.1007/bf00562621.
    参考文献:10.1177/096032719601500805
    摘要:Hoetelmans RM, Otten JM, Koks CH, Soesan M, Beijnen JH. Combined dapsone and clofazimine intoxication. Hum Exp Toxicol. 1996 Aug;15(8):625–8. doi: 10.1177/096032719601500805.
    参考文献:10.1097/00007691-199610000-00012
    摘要:Eljaschewitsch J, Padberg J, Schürmann D, Ruf B. High-performance liquid chromatography determination of pyrimethamine, dapsone, monoacetyldapsone, sulfadoxine, and N-acetyl-sulfadoxine after rapid solid-phase extraction. Ther Drug Monit. 1996 Oct;18(5):592–7. doi: 10.1097/00007691-199610000-00012.
    参考文献:10.1186/1745-6673-1-9
    摘要:Kosseifi SG, Guha B, Nassour DN, Chi DS, Krishnaswamy G. The Dapsone Hypersensitivity Syndrome revisited: a potentially fatal multisystem disorder with prominent hepatopulmonary manifestations. Journal of Occupational Medicine and Toxicology. 2006 Jun 06;1(1):9. doi: 10.1186/1745-6673-1-9.
    摘要:Najim RA, Farid YY, Samad TA, Shihab SA. Acetylator phenotype in Iraqi patients with systemic lupus erythematosus. East Mediterr Health J. 2005 Sep;11(5-6):1003–8.
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