专利号:US-2019292310-A1 优先权日:2018-03-20 标 题:Synthesis of high density molecular dna brushes via organic-phase ring-opening metathesis (co)polymerization 发明人:ZHANG KE; TAN XUYU 权利人:UNIV NORTHEASTERN 摘要:The invention provides novel synthetic methods for oligonucleotide polymerization reactions that separate the deprotection and cleavage step following solid-phase oligonucleotide synthesis into two separate steps, thereby providing fully protected hydrophobic oligonucleotides that can be further manipulated in organic solvents. The disclosed methods enable the synthesis of new structures, such as brush DNA and brush RNA polymers and micellar spherical nucleic acids (SNAs
专利号:US-6262251-B1 优先权日:1995-10-19 标题 :Method for solution phase synthesis of oligonucleotides 发明人:PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING 权利人:PROLIGO LLC 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.
专利号:US-4670563-A 优先权日:1984-06-20 标题 :Imidazolides as intermediates for the synthesis of cytotoxic conjugates 发明人:JANSEN FRANZ; GROS PIERRE 权利人:SANOFI SA 摘要:Imidazolides of the formula: ##STR1## in which: E represents an inert spacing structure; and n G represents a group: ##STR2## or a group --S--S--X, in which X is an activating group. Application: synthesis of cytotoxic conjugates.
专利号:WO-9847910-A1 优先权日:1997-04-21 标题:Method for solution phase synthesis of oligonucleotides 发明人:PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S 权利人:NEXSTAR PHARMACEUTICALS INC; PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.
专利号:US-5874532-A 优先权日:1997-01-08 标 题 :Method for solution phase synthesis of oligonucleotides and peptides 发明人:PIEKEN WOLFGANG; GOLD LARRY 权利人:NEXSTAR PHARMACEUTICALS INC 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.
专利号:US-6001966-A 优先权日:1995-10-19 标题 :Method for solution phase synthesis of oligonucleotides and peptides 发明人:PIEKEN WOLFGANG; GOLD LARRY 权利人:PROLIGO LLC 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.
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合成参考文献
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