CAS: 52435-06-0; Surfagon
该化合物是一种复杂的浸渍物,其特征是氨酸的序列,与联结相连;该化合物具有浸渍剂的典型特征,包括潜在的生物活动,例如与生物系统中的受体或酶的相互作用;其结构包括各种功能组,可能有助于其溶性,稳定性和反应性;特定氨基酸的存在表明其在信号路径或作为治疗剂方面可能发挥作用;此外,列入二氨基甲基基乙酸组表明有可能进一步进行化学反应或改变;总的来说,该物质对生物化学研究感兴趣,并可能在药理学或药理化学中应用,尽管具体的生物活动和特性需要经验调查才能充分说明其在生物环境中的行为.
- 英文名称Surfagon
- 中文名称6-D-丙氨酸-9-(N-乙基-L-脯氨酰胺)-10-去甘氨酰胺-促黄体激素-释放激素
- IUPAC名称(S)-N-ethyl-1-(((R)-5-oxopyrrolidine-2-carbonyl)-L-histidyl-L-tryptophyl-D-seryl-L-tyrosyl-D-alanyl-L-leucyl-L-arginyl)pyrrolidine-2-carboxamide
- 其它别名Luteinizinghormone-releasing factor (pig), 6-D-alanine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-; Alarelin; D-Ala6-des-Gly10-LH-releasing hormone ethylamide; Dalarelin; Dalareline; Surfagon; [6-D-Alanine,10-des-glycine]-LH-releasing hormone ethylamide; [D-Ala6,Des-Gly10-NH2]-GnRH ethylamide; [D-Ala6,Des-Gly10-NH2]-LH-RHethylamide; [D-Ala6,Pro9-N-ethylamide]-LH-RH; [D-Ala6-des-Gly10]-Gonadotropin-releasing hormone ethylamide; [D-Ala6]des-Gly10-GnRH-N-ethylamide; [D-Ala6]des-Gly10-LH-RH N-ethylamide; [Des-Gly10,D-Ala6]-LH-RH ethylamide; [Des-Gly10,D-Ala6]-LH-releasing hormoneethylamide; pGlu-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHC2H5
- CAS编号52435-06-0
- EINECS号:688-471-4
- FDA UNII编号:NJS328SUA7
- 分子式:C56H78N16O12分子量:1167.3
- 产品CID: 2533342
- 产品分类生物化工 → 氨基酸及其衍生物 → 丙氨酸类衍生物
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专利信息
专利号:WO-2023030277-A1
优先权日:2021-08-30
标 题:Method for fully liquid-phase synthesis of grnh nonapeptide amide analog
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN MICRO PEPTIDE BIOMEDICAL CO LTD
摘要:Provided is a method for fully liquid-phase synthesis of a GRnH nonapeptide amide analog, which belongs to the technical field of medicine synthesis. The method comprises respectively synthesizing a 'Trp-Ser-Tyr' fragment, an 'R-Leu' fragment, a 'Pyr-His' fragment and 'Arg-Pro-Hunan T', wherein, R = D-Ala (alarelin), D-Leu (leuprorelin), D-Trp (deslorelin) and D-His (histrelin), and obtaining the GRnH nonapeptide amide analog with high yield and high purity by means of a '3 +2 +2 +2' fragment condensation method. The synthesis method is environmentally friendly, mild, and free of any highly toxic and poisonable reagents. The cost is greatly reduced and the synthesis method is very suitable for large-scale production.
专利号:CN-120192237-A
优先权日:2023-12-22
标 题 :Synthesis and application of novel non-classical solid phase synthesis carrier
专利号:CN-102702327-A
优先权日:2012-06-20
标题:A kind of solid-liquid phase synthesis method of Alarelin
专利号:CN-113735940-B
优先权日:2020-05-31
标题:A kind of solid phase synthesis method of peptide
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Krivosheev OG, Nabatchikova NA, Pozdniakova GI, Siutkin EA, Vinogradov VA. [Biological activity of surfagon--a synthetic luliberin agonist]. Probl Endokrinol (Mosk). 1988 Nov-Dec;34(6):62-6. Russian. Russian. Russian. Russian. Russian. Russian. Russian. Russian. Russian. Russian. doi: 10.1111/j.1439-0531.2010.01723.x. Epub 2010 Dec 6. Russian. Ukrainian. Chinese.
合成参考文献
摘要:Acta Europaea Fertilitatis., 11(113), 1980 []
摘要:Sachyns'ka OV. [Nucleic acid and protein content in rat prostate during combined treatment with the gonadorelin agonist and an androgen receptor inhibitor]. Fiziol Zh (1994). 2001;47(6):30–4.
参考文献:10.3109/01485018508988293
摘要:Jegou B, Brekke I, Naess O, Torjesen P, Hansson V. Properties and regulation of GnRH receptors in the anterior pituitary and the testis of the rat: different response of Leydig cell LH and GnRH receptors to hormonal treatments. Arch Androl. 1985;14(2-3):161–70. doi: 10.3109/01485018508988293.
参考文献:10.1016/s0022-4731(85)80003-0
摘要:Catt KJ, Loumaye E, Wynn PC, Iwashita M, Hirota K, Morgan RO, Chang JP. GnRH receptors and actions in the control of reproductive function. J Steroid Biochem. 1985 Nov;23(5B):677–89. doi: 10.1016/s0022-4731(85)80003-0.
参考文献:10.1016/s0022-4731(85)80010-8
摘要:Dufau ML, Knox GF. Fetal Leydig cell culture--an in vitro system for the study of trophic hormone and GnRH receptors and actions. J Steroid Biochem. 1985 Nov;23(5B):743–55. doi: 10.1016/s0022-4731(85)80010-8.
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