CAS: 51871-62-6; Boc-ß-Hophe-Oh

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Ethoxycarbonyl (2S)-2-[(2-Methylpropan-2-yl)Oxycarbonylamino]-3-Phenylpropanoate置于silver Benzoate,Silica Gel体系中,用 四氢呋喃,乙酸乙酯 作为反应溶剂,化学反应 0.5H,反应生成 (S)-3-(Boc-氨基)-4-苯基丁酸
参考文献:含有β3-同位氨基酸的tapp类似物:合成和受体结合.
标题:含有β3-同位氨基酸的tapp类似物:合成和受体结合.
摘要:含有α,β-杂合肽的β-氨基酸具有拟肽的巨大潜力.在本文中,我们描述了四肽tyr-D-Ala-Phe-Phe-Nh 2(tapp)的类似物α,β-杂化物的合成及其对μ阿片和δ阿片受体的亲和力.每个氨基酸与置换升或-D-β 3-ħ α-氨基酸.tapp类似物的所有α,β杂化物均在溶液中合成,并测试了对μ阿片和δ阿片受体的亲和力.模拟的tyr-β 3 ħ-D-Ala-Phe-Phenh 2被认为是作为活性与天然四肽.版权所有©2012欧洲肽协会和john Wiley&sons,Ltd.
DOI:10.1002/psc.2433

专利信息

专利号:US-2003158436-A1
优先权日:1999-03-10
标题:Synthesis of alpha--amino-alpha, alpha'- dihaloketones and process for the preparation of beta--amino acid derivatives by the use of the same

专利号:US-6573399-B1
优先权日:1999-03-10
标题:Synthesis of α-amino-α′, α′-dihaloketones and process for the preparation of β-amino acid derivatives by the use of the same
发明人：NISHIYAMA AKIRA; INOUE KENJI
权利人:KANEKA CORP
摘要:The present invention provides a commercially profitable process for producing a β-amino acid ester derivative n which comprises reacting an α-amino acid ester derivative with a base and a dihalomethane, n reacting the same with a lithium amide and an alkyllithium in succession, n and treating the reaction product with an acid in an alcohol.

专利号:EP-1078919-A1
优先权日:1999-03-10
标题 :SYNTHESIS OF $g(a)-AMINO-$g(a)',$g(a)'-DIHALOKETONES AND PROCESS FOR THE PREPARATION OF $g(b)-AMINO ACID DERIVATIVES BY THE USE OF THE SAME

专利号:EP-1078919-B1
优先权日:1999-03-10
标题 :Synthesis of alpha-amino-alpha',alpha'-dihaloketones and process for the preparation of beta)-amino acid derivatives by the use of the same