吡嗪置于potassium Permanganate,Potassium Amide体系中,用 氨 作为反应溶剂,化学反应 0.17H,以65%的收率获得产物氨基吡嗪 参考文献:Hara,Hiroshi; Plas,Henk C. Van Der,Journal Of Heterocyclic Chemistry,1982,Vol. 19,P. 1285-1287 标题:Hara,Hiroshi; Plas,Henk C. Van Der,Journal Of Heterocyclic Chemistry,1982,Vol. 19,P. 1285-1287
专利信息
专利号:US-9663477-B1 优先权日:2014-09-19 标题:Synthesis and structure of 3,5-diamino-2,6-di-(tert-butyl-NNO-azoxy) pyrazine as a critical intermediate in the synthesis of a novel energetic compound 发明人:WILSON REBECCA M; MANNION JOSEPH D; MORAN JESSE S 权利人:WILSON REBECCA M; MANNION JOSEPH D; MORAN JESSE S; US NAVY 摘要:The present disclosure relates generally to a critical intermediate in a synthesis of a postulated energetic material, and more specifically relates to a critical intermediate, 3,5-diamino-2,6-di-(tert-butyl-NNO-azoxy)pyrazine, having the structure: n nThe postulated energetic material has calculated performance properties that greatly exceed those of HMX and CL-20. The specific critical intermediate (Compound 1) shown above has a molecular weight of 310.359 g/mol, a density at −123° C. of 1.293 g/mL, and a density at 20° C. of 1.259 g/mL.
专利号:US-6566292-B2 优先权日:2001-03-27 标 题 :Process for the enhancement of the cycle life of a zinc-chromium based catalyst in the synthesis of 2-methylpyrazine 发明人:POTHARAJU SEETHARAMANJANEYA SA; RAGHAVAN KONDAPURAM VIJAYA; RAO PANJA KANTA; KULKARNI SHIVANAND JANARDAN; RAO KATABATHINI NARASIMHA; GOPINATH RAJESH; FARSINAVIS SURESH; MESHRAM HARSHADAS MITARAM 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to enhancement of the cycle life of a zinc chromium based catalyst used in the synthesis of 2-methylpyrazine by increasing the reaction temperature step-wise, starting from a low temperature, while monitoring the levels of total conversion and selectivity towards pyrazine. The catalyst can be regenerated after each cycle of use without substantial loss of activity.
专利号:EP-1373226-B1 优先权日:2001-03-30 标题 :Process for the enhancement of cycle life of a zinc-chromium based catalyst in the synthesis of 2-methylpyrazine 发明人:POTHARAJU SEETHARAMANJANEYA SA; RAGHAVAN KONDAPURAM VIJAYA; RAO PANJA KANTA; KULKARNI SHIVANAND JANARDAN; RAO KATABATHINI NARASIMHA; GAPINATH RAJESH; FARSINAVIS SURESH; MESHRAM HARSHADAS MITARAM 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to enhancement of the cycle life of a zinc chromium based catalyst used in the synthesis of 2-methylpyrazine by increasing the reaction temperature step-wise, starting from a low temperature, while monitoring the levels of total conversion and selectivity towards pyrazine. The catalyst can be regenrated after each cycle of use without substantial loss of activity.
专利号:US-11926624-B2 优先权日:2018-06-29 标 题:Synthesis of coelenterazine synthesis intermediate 发明人:DUVVURU RAJAGOPALA REDDY 权利人:INT PAPER CO 摘要:Disclosed herein are synthesis methods for coelenterazine and intermediates. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.
专利号:US-11939332-B2 优先权日:2018-06-29 标题:Synthesis of coelenterazine 发明人:DUVVURU RAJAGOPALA REDDY; BHATT RAMA; KUMAR ANIL 权利人:INT PAPER CO 摘要:Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.
专利号:US-2022356182-A1 优先权日:2009-03-27 标题 :Inhibitors of hepatitis c virus replication 发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
[参考文献]: Abdullah M Asiri, Et Al. Synthesis Of Some New Anils: Part 1. Reaction Of 2-Hydroxy-Benzaldehyde And 2-Hydroxynaphthaldehyde With 2-Aminopyridene And 2-Aminopyrazine. Molecules. 2007 Aug 13;12(8):1796-804. [参考文献]: Anna Eriksson, Et Al. Identification Of Akn-032, A Novel 2-Aminopyrazine Tyrosine Kinase Inhibitor, With Significant Preclinical Activity In Acute Myeloid Leukemia. Biochem Pharmacol. 2010 Nov 15;80(10):1507-16. [参考文献]: Frédéric De Wael, Et Al. Chemistry Around Imidazopyrazine And Ibuprofen: Discovery Of Novel Fatty Acid Amide Hydrolase (Faah) Inhibitors. Eur J Med Chem. 2010 Sep;45(9):3564-74. [参考文献]: J F Cavalier, Et Al. Catechol Derivatives Of Aminopyrazine And Cell Protection Against Uvb-Induced Mortality. Bioorg Med Chem. 2001 Apr;9(4):1037-44. [参考文献]: Muhammad Ahsan Hashir, Et Al. Identification Of Low Molecular Weight Carbohydrates Employing New Binary Mixtures For Matrix-Assisted Laser Desorption/ionisation Mass Spectrometry. Rapid Commun Mass Spectrom. 2008 Jul;22(14):2185-94.
合成参考文献
摘要:Sato, N., Science of Synthesis Knowledge Updates, (2011) 4, 282. 摘要:Sato, N., Science of Synthesis Knowledge Updates, (2011) 4, 328. 摘要:Glushkov, V. A.; Shklyaev, Yu. V., Science of Synthesis Knowledge Updates, (2018) 3, 263. 摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 414. 摘要:Sato, N., Science of Synthesis Knowledge Updates, (2011) 4, 334.