CAS: 487-68-3; 2,4,6-Trimethylbenzaldehyde

上下游产品

CAS号40188-34-9 2,4, 6-Trimethy... | CAS号4761-00-6 2,4,6-三甲基溴苄 | CAS号4170-90-5 2,4,6-三甲基苄醇 | CAS号938-18-1 2,4,6-三甲基苯甲酰氯 | CAS号201230-82-2 carbon monoxide | CAS号108-67-8 均三甲苯 | CAS号576-83-0 2-溴均三甲基苯 | CAS号25891-31-0 三甲酰胺 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1585-16-6 2,4,6-三甲基氯苄 | CAS号106567-41-3 2,4,6-trimethyl... | CAS号105205-91-2 N-benzyl-1-(2,4... | CAS号527-53-7 1,2,3,5-四甲基苯 | CAS号108-67-8 均三甲苯 | CAS号15138-39-3 2,4,6-trimethyl... | CAS号4170-90-5 2,4,6-三甲基苄醇 | CAS号5215-40-7 2,4,6-trimethyl... | CAS号480-63-7 2,4,6-三甲基苯甲酸 | CAS号109466-65-1 3,4-dihydro-6,8... | CAS号6948-41-0 Cyclohexanol,2,...

2,4,6-三甲基苄醇置于3-(6-(3,5-Dimethyl-1H-Pyrazol-1-yl)Pyridin-2-yl)-1-(2-((1-Oxyl-2,2,6,6-Tetramethylpiperidin-4-yl)Oxy)-2-Oxoethyl)-1H-Imidazol-3-Ium Iodide,氧气,Sodium Carbonate,Copper(I) Bromide体系中,化学反应 24.0H,以88%的收率获得产物2,4,6-三甲基苯甲醛
参考文献:带有离子液体部分和n,N-双齿基团的可回收tempo衍生物的设计,可将cu(i)高效催化将醇转化为醛和亚胺†
标题:带有离子液体部分和n,N-双齿基团的可回收tempo衍生物的设计,可将cu(i)高效催化将醇转化为醛和亚胺†
摘要:制备了四种不同类型的tempo衍生物,并结合了离子液体部分和n,N-双齿配位基团(il-tempo-N,N).所述的cubr / Il-Tempo-ñ,ñ系统表现出对醛和亚胺的合成高催化活性通过在1-丁基-3-甲基咪唑鎓四氟硼酸盐的醇的有氧氧化([bmim] Bf 4).均相催化体系中的铜催化剂和il-tempo-N,N助催化剂可通过使用et 2萃取同时从产物中回收o.离子液相中剩余的催化剂体系可重复使用数个循环,而不会明显降低催化活性.建立了将酒精高效,可再循环地好氧氧化为醛和亚胺的方案.
DOI:10.1039/c6Ra10373A

专利信息

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-10913749-B2
优先权日:2015-05-07
标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-11136335-B2
优先权日:2016-06-30
标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-8618281-B2
优先权日:2006-01-03
标 题 :Geometric synthesis of porphyrin rods
发明人：LINDSEY JONATHAN S; YU LIANHE; THAMYONGKIT PATCHANITA; BHISE ANIL D
权利人:LINDSEY JONATHAN S; YU LIANHE; THAMYONGKIT PATCHANITA; BHISE ANIL D; UNIV NORTH CAROLINA STATE
摘要:A method of making a compound of Formula I′ n ncomprises reacting a compound of the formula DLCHO, with a compound of the formulan n nto produce the compound of Formula I′. Methods of using the compounds are also described, particularly as intermediates for the synthesis of porphyrin rods, which porphyrin rods are in turn useful for (among other things) the production of molecular memory devices.