CAS: 344-20-7; 2,6-Dibromo-4-Fluorophenol

该化合物是一种有机化合物,其特征是存在两个溴原子和一个附于苯球圈的氟原子,其分子结构具有氢氧基组(-OH),有助于将其分类为苯酚,该化合物一般在室温时是固体,以其在包括制药和农用化学品在内的各个领域的潜在用途而著称,卤素分体的存在,特别是溴和氟,可对其化学反应,溶解和生物活动产生重大影响. 2,6-二溴-4-氟酚可能具有抗微生物特性,并可作为合成更复杂的有机分子的中间体.重要的是,要谨慎地处理这一化合物,因为卤化苯醇可能对环境和健康造成危害.在与该物质打交道时,应注意采取适当的安全措施,包括使用个人防护设备和遵守有关危险材料的相关条例.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号371-41-5 4-氟苯酚 | CAS号371-40-4 4-氟苯胺 | CAS号74-88-4 碘甲烷 | CAS号7726-95-6 溴素 | CAS号64-19-7 冰醋酸 | CAS号398-23-2 4,4'-二氟联苯 | CAS号443-41-4 1,3-二溴-5-氟-2-甲氧基苯 | CAS号130046-78-5 2-(Benzyloxy)-1... | CAS号319-50-6 2-(2,6-dibromo-... | CAS号245762-36-1 5-Fluoro-2,3-di... | CAS号19643-45-9 2,6-二溴對苯醌

合成工艺路线路线简述

    📜4-氟苯酚置于dibromamine-T体系中,用 乙腈 用作溶剂,化学反应 0.17H,以78%的收率获得2,6-二溴-4-氟苯酚
    参考文献:在没有任何催化剂的情况下使用 Tsnbr2 快速和完全溴化芳族化合物
    标题:在没有任何催化剂的情况下使用 Tsnbr2 快速和完全溴化芳族化合物
    摘要:摘要 N,N-二溴对甲苯磺酰胺(Tsnbr2)是一种用于芳香族化合物溴化的新型试剂.反应速度极快,在环境温度下瞬间完成,只生成相应的多溴化产物.该程序适用于各种苯酚,苯甲醚和苯胺,以优异的收率获得相应的多溴化化合物作为单一产品.图形概要
    Doi:10.1080/00397911.2014.956367

    海关参考信息

    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-5817690-A
    优先权日:1996-08-27
    标 题:4-aminoethoxy indolone derivatives
    发明人：MEWSHAW RICHARD ERIC
    权利人:AMERICAN HOME PROD
    摘要:A compound of the formula I: I in which Y is hydrogen, halogen or lower alkoxy; R1 is hydrogen, lower alkyl or aryl(lower)alkyl; R2 is hydrogen, lower alkyl or -(CH2)nXpAr, where X is oxygen or carbonyl; Ar is cycloalkyl, aryl or arylaryl, oxindolyl, benzimidazolyl, indolyl, 2-oxobenzimidazolyl or 2-thioxobenzimidazolyl; or R1 and R2, taken together with the nitrogen atom to which they are attached, complete a 3,4-dihydro-1H-isoquinolinyl or 1,3-dihydro-isoindolyl; n is one of the integers 1,2,3,4,5 or 6; p is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.

    专利号:EP-0923551-B1
    优先权日:1996-08-27
    标题:4-aminoethoxy indolone derivatives
    发明人：MEWSHAW RICHARD ERIC
    权利人:AMERICAN HOME PROD
    摘要:A compound of formula (I) in which Y is hydrogen, halogen or lower alkoxy; R1 is hydrogen, lower alkyl or aryl(lower)alkyl; R2 is hydrogen, lower alkyl or -(CH2)nXpAr, where X is oxygen or carbonyl; Ar is cycloalkyl, aryl or arylaryl, oxindolyl, benzimidazolyl, indolyl, 2-oxobenzimidazolyl or 2-thioxobenzimidazolyl; or R1 and R2, taken together with the nitrogen atom to which they are attached, complete a 3,4-dihydro-1H-isoquinolinyl or 1,3-dihydro-isoindolyl; n is one of the integers 1,2,3,4,5 or 6; p is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.

    专利号:EP-0923576-B1
    优先权日:1996-08-27
    标题 :4-aminoethoxy-indolone derivatives as dopamine d2 agonists
    发明人：MEWSHAW RICHARD ERIC; WEBB MICHAEL BYRON
    权利人:WYETH CORP
    摘要:A compound of formula (I) in which Y is hydrogen, halogen or alkoxy; R is hydrogen or alkylthio; R1 is hydrogen or alkyl; X is hydrogen, halogen, alkoxy, alkyl or phenyl; n is one of the integers 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of shizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.

    专利号:US-5760070-A
    优先权日:1996-08-27
    标 题 :4-Aminoethoxy indolone derivatives
    发明人：MEWSHAW RICHARD ERIC; WEBB MICHAEL BYRON
    权利人:AMERICAN HOME PROD
    摘要:A compound of the formula I: I in which Y is hydrogen, halogen or alkoxy; R is hydrogen or alkylthio; R1 is hydrogen or alkyl; X is hydrogen, halogen, alkoxy, alkyl or phenyl; n is one of the integers 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.

    专利号:CN-110143852-A
    优先权日:2019-06-28
    标 题:A method of photocatalytic synthesis is at more bromophenol compounds in water phase

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    合成参考文献


    摘要:Aitken, K. M.; Aitken, R. A., Science of Synthesis, (2007) 31, 1276.
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